Description
Inlybest 5 mg (Axitinib) belongs to the class of inhibitor anti-cancer drugs employed for managing patients with advanced renal cell carcinoma (kidney cancer) in adults. The drug is recommended if the systemic therapy given earlier, fails to provide suitable care to the patients. Inlybest 5 mg (Axitinib) should be taken orally two times a day about 12 hours apart from each dose. It can be taken with or without food.
Inlybest 5 mg (Axitinib) is known for selectively inhibiting the proliferation processes of cancer cells which include angiogenesis (formation of new blood vessels), growth and metastases (spread) of these cells. Inlybest 5 mg (Axitinib) gets immediately absorbed in the system in between 2.5 to 4.1 hours. Furthermore, it binds efficiently (binding affinity-99%) with cancer cells and completes its inhibitory action leading to the decreased cancer toll on the body. After finishing its activities, it takes around 2.5 to 6.1 hours to eliminate 50% of the drug.
Modification of dosage:
Based on the safety and tolerability of patients, Inlybest 5 mg (Axitinib) dosing may be modified. They are mentioned in the table given below.
| Type of patients | Side-effects | Dosing modification 1 | Dosing modification 2 |
| Normotensive (Normal BP) and not receiving any ant-hypertensive medications | Absent | Increased to 7 mg twice daily | Increased to 10 mg twice daily |
| – | Present | Decreased to 3 mg twice daily | Decreased to 2 mg twice daily |
Warnings and Precautions before taking Inlybest 5 mg (Axitinib):
It is important to inform the healthcare provider about certain conditions before initiating the drug including,
- High BP (Hypertension)
- Bleeding complications
- Problems in the thyroid gland
- Liver dysfunctions
- Prior or recent surgery
- The history of blood clots in the veins and arteries (Stroke, heart attack, or problems in the eyes)
- Other severe medical conditions
- Unhealed wound
- Pregnancy
Additionally, it is imperative to notify doctors about other medications (if they are taking any). In any case, if patients miss the prescribed dose, they should avoid taking another dose and follow the dosing schedule.
Side-effects of Inlybest 5 mg (Axitinib):
Most common side-effects:
- Diarrhea
- Tiredness
- Weakness
- Nausea
- Loss of weight
- Vomiting
- Constipation
- Decreased will to eat
- Rashes, redness, itching or peeling of skin on hands
- Hoarseness
Serious side-effects:
| Conditions | Blood clots in the veins and arteries | Bleeding | Tear in the stomach or intestinal wall | Problems in the thyroid gland | RPLS | Heart failure |
| Signs and Symptoms | Pain in the chest, arms, back, neck and jaws | Gum bleeding | Severe pain in the abdomen | Unusual tiredness | High BP | Tiredness |
| Weakness on one side of the body | Severe bleeding | Vomit blood | Weight gain or loss | Seizures | Abdominal swelling | |
| Shortness of breath | Heavy menstrual bleeding | Red or black stools | Hair loss | Weakness | Shortness of breath | |
| Headache | Headache | Feeling hot or cold | Headache | Swelling in the legs or ankles | ||
| Changes in the vision | Dizziness/ Weakness | Deepened voice | Confusion | Veins protruding out of the neck | ||
| Pink or brown urine | Cramps in the muscles | Blindness | ||||
| Tar-like stools and coughing out blood which looks like coffee-grounds |
Note: RPLS: Reversible Posterior Leukoencephalopathy Syndrome (Unusual swelling in the brain)
Other severe side-effects:
- Hypertension (High BP)
- Proteinuria (Excessive amounts of protein in the urine)
- Liver dysfunctions
- Wound healing complications due to a surgical procedure
Note: These are not all side-effects of Inlybest 5 mg (Axitinib), inform your healthcare provider if you witness others.
