Lenalidomide Capsules
Aprazer Healthcare is a certified WHO-GMP manufacturer and global exporter of Lenalidomide Capsules (Lenakast 10mg, 25mg). High clinical efficacy for Multiple Myeloma and MDS.
Formulation Insights
Comprehensive Medical Overview
Lenalidomide
Therapeutic Classification: Anticancer medicine
What is Lenalidomide?
It is immunomodulatory in nature.
It is used in various cancer treatments.
Lenakast (Lenalidomide 10 mg, 25 mg capsules), manufactured by Aprazer Healthcare, is available globally.
Aprazer Healthcare is an oncology drug manufacturer.
Our oncology segment spans oncology orals and injectables.
Specialized in manufacturing targeted therapy drugs, we are globally certified and accepted.
Our manufacturing facilities comply with WHO-GMP standards.
What are the uses of Lenalidomide?
It is used for the treatment of blood-related disorders.
• Multiple Myeloma
• Myelodysplastic syndromes associated with transfusion-dependent anemia in qualified individuals.
• Mantle Cell Lymphoma in specified regions
How does Lenalidomide work?
It impairs the working of specific proteins involved in cancer cell growth.
It enhances immune function to damage cancer cells.
It may inhibit the supply of nutrients to the cancer cells.
What are the side effects of Lenalidomide?
• Diarrhea/constipation
• Weakness/fatigue
• Pruritus/skin rashes
• Muscle spasms
• Edema
• Sleep difficulties
• Nausea
• Reduced appetite
Serious side effects:
• Allergic reaction
• Life-threatening birth defects
• Increased risk of secondary malignancies
• Risk of severe infections
• Severely low blood count
• Tumor flare reaction
Warnings associated with Lenalidomide-
It may increase the risk of clot formation in veins and arteries when used with dexamethasone and certain other drugs.
Lenalidomide is contraindicated in pregnancy.
People with known hypersensitivity to the drug must avoid its use.
Lenalidomide may lower the blood count; it requires monitoring of the total blood count.
It requires careful evaluation and monitoring of –
• Hepatic function
• Renal function
Precautions with the use of Lenalidomide-
Patients must avoid donating blood or sperm during the treatment.
Lenalidomide is toxic in nature; one must avoid opening the capsule.
It may increase the risk of tumor lysis syndrome in certain people.
Lenalidomide increases the risk of infections; one must use preventive measures to avoid infections.
It may cause bleeding; always report to your doctor if blood occurs in stool or urine.
Hepatitis B infection must be accessed before starting the treatment.
Conditions that require cautious use-
• Kidney disorders
• Bleeding disorder
• Cardiovascular issues
• Bone marrow suppression
• Liver disorders
Lenalidomide drug interactions-
Concomitant use of certain drugs may affect blood functioning.
It must be carefully evaluated for its use with -
Estrogen drug therapies, Warfarin
Digoxin use with lenalidomide may increase blood levels of the drug.
Immunosuppressants with lenalidomide may increase the risk of myelosuppression.
Lenalidomide use must be monitored for –
• Total blood count – CBC
• Kidney function – monitor serum creatinine and calculated CrCl.
• Liver function- AST, ALT, and bilirubin levels
• Reproductive /pregnancy status
• Thromboembolic events
FAQ
Frequently Asked Questions
Why is donating body fluids while on lenalidomide therapy unsafe?
One must not donate blood or sperm, as the drug may pass into the body fluids.
Can I dissolve the contents of the capsule?
The capsule must be swallowed whole.
Opening the capsule may cause accidental contact.
The powder is toxic in nature.
Will Lenalidomide affect my weight?
It reduces appetite, which may affect weight.
Will it cause a complete loss of hair?
Severity of hair loss varies in every individual.
Why should I tell my doctor about lenalidomide use before tooth extraction?
The medicine may interfere with the healing process.
It must be reported to the doctor before any surgical procedure.