ACALAKAST 100mg
Acalabrutinib -100 mg
ACALAKAST 100mg
Composition:
Each capsule contains Acalabrutinib – 100 mg
Therapeutic Class:
Antineoplastic
What is Acalakast?
Acalakast is a new-generation Bruton’s Tyrosine Kinase (BTK) inhibitor, used in targeted therapy against white blood cancers, specifically B-cell malignancies.
Uses of Acalakast:
- • Chronic Lymphocytic Leukemia
- • Lymphocytic Lymphoma
- • Mantle Cell Lymphoma
How does Acalakast work?
In B-cell cancers, abnormal B-cells grow and spread uncontrollably. Acalabrutinib blocks the kinase enzyme (BTK), which disrupts the signaling pathway responsible for B-cell division and growth.
Common Side Effects:
Headache, nausea, vomiting, constipation, diarrhea, joint pain, abdominal pain, and fatigue.
Serious Side Effects:
Fever, sore throat, blood in stool, infections, and fast/irregular heartbeat.
Warning:
Not to be used in patients with known hypersensitivity to Acalabrutinib or any of its excipients.
Precautions:
Use with caution in:
- • Renal insufficient patients
- • Breastfeeding mothers
- • Pregnant women
Toxicities:
Common toxicities include:
- • Neutropenia – Increased risk of infections
- • Thrombocytopenia – Risk of bleeding
- • Anemia – Decreased red blood cell count
Other toxicities: Atrial fibrillation, bleeding, hypertension, skin infections
Indications for Use:
Acalakast is a prescription medication to be used under medical supervision only.
While generally well tolerated, it requires regular monitoring for blood counts, infections, bleeding risks, and cardiac toxicities.
FAQ
Frequently Asked Questions
It is recommended to avoid drinking alcohol with Acalakast (acalabrutinib) capsules. Why?
It worsens the side effects.
Do not get tooth extractions when on Acalakast (acalabrutinib) therapy. Why?
- It delays healing.
- Increase risk of bleeding.
Avoid sun exposure with Acalakast (acalabrutinib) capsules. Why?
It can lead to sunburn.
Do not take antacids/PPIs with Acalakast (acalabrutinib) capsule. Why?
Take a gap of 2 hours.
What are the serious risks of using Acalakast (acalabrutinib) capsule?
- Serious infection
- Bleeding
- Arterial fibrillation
- Secondary cancers
Can Acalakast (acalabrutinib) therapy increase blood pressure?
It can increase BP.
Regularly monitor blood pressure.
Which is the global drug exporter of anti-cancer drugs?
Aprazer Healthcare is the drug manufacturer.
