L-Aprakast
Composition: L Asparaginase 10000 IU for IM and IV administration
Therapeutic Class: Antineoplastic agent
L-Aprakast: Global Standard Anti Cancer Medicine
Aprazer manufactures the widest range of oncology medicines that are widely prescribed by healthcare professionals, ensuring consistent quality and efficacy.
- • WHO-GMP certified
- • Assured therapeutic efficacy and safety
- • Affordability
- • Global reach – exporting to 20+ countries.
What is L-Aprakast?
It is an anticancer drug, extracted from E. coli, and is used against various cancers of the blood.
How does it work?
- • It inhibits the asparagine enzyme
- • Blocks protein synthesis in cancer cells
- • Causes cancer cell death
Uses of L-Aprakast
- • Lymphoblastic leukemia (Acute)
- • Lymphoblastic lymphoma
Common Side Effects of L-Aprakast
These are mild to moderate side effects and can be managed with supportive care:
- • Nausea, vomiting
- • Fever
- • Weakness
- • Stomach issues
- • Skin rashes
- • Local venous necrosis
Toxicities
- Gastrointestinal toxicity
- Hepatotoxicity
- Hyperglycemia
- Hemorrhage / internal bleeding
- Hyperlipidemia
Contraindications
- • Not to be used in patients with prior hypersensitivity to the drug or its excipients
- • Breastfeeding mothers
- • Pregnant women
Precautions
To be used cautiously in patients with:
- • Heart disease
- • Blood disorders
- • Liver disease
- • Pancreatitis
Warnings
To be used under medical supervision only. Do not mix with dextrose-containing solutions due to incompatibility.
Important Safety and Monitoring Information
Regular monitoring is required for:
- • Liver functions
- • Pancreatic enzymes
- • Blood coagulants
- • Sugar levels
Handling Precautions
L-asparaginase is cytotoxic; handle wearing gloves to prevent causative effects.
Storage:
Store at 2-8 degrees Celsius (refrigerator), protected from light.
Reconstituted solution to be used immediately.
FAQ
Frequently Asked Questions
Which is the affordable L-Asparaginase injection?
L- Aprakast
It is manufactured by Aprazer Healthcare.
It is used globally for blood cancer.
Can L-Aprakast (L-asparaginase) injection alter glucose levels?
It increases the blood sugar levels.
L-Aprakast (L-asparaginase) causes a silent allergy. Explain?
The body produces an inflammatory response against the drug.
The symptoms are invisible.
It deactivates L-asparaginase.
What are the serious effects of L-Aprakast (L-asparaginase)?
- Pancreatitis
- Thromboembolism
- Abnormal bleeding
- High blood sugars
- Hepatotoxicity
What should be monitored with L-Aprakast (L-asparaginase)?
- Pancreatic functions
- Bleeding functions
- Glycemic index
L-Aprakast (L-asparaginase) interferes with lab reports. How?
It can cause a false report.
It mimics hypothyroidism.
The report is stabilized after the treatment.
The blood levels of L-Aprakast (L-asparaginase) are monitored. Why?
An anti-inflammatory response may destroy the drug.
Aprazer Healthcare is a trusted Indian drug manufacturer. Why?
Aprazer Healthcare is a global pharmaceutical company.
Reference Link
https://medlineplus.gov/druginfo/meds/a612034.html
L-asparaginase in the treatment of patients with acute lymphoblastic leukemia
https://pmc.ncbi.nlm.nih.gov/articles/PMC4936081/
