NSAIDs Combinations
Non-Steroidal Anti-Inflammatory Drug (NSAID) combinations combine potent analgesic and anti-inflammatory compounds with muscle relaxants or gastroprotective agents. They are designed to alleviate acute and chronic pain, reduce swelling, and manage musculoskeletal conditions while optimizing patient comfort.
| S.No. | Dosage Form | Composition | Action |
|---|---|---|---|
| 189 | Tablets | Aceclofenac 100 mg + Diacerein 50 mg | |
| 190 | Tablets | Aceclofenac 100 mg + Paracetamol 325 mg + Thiocolchicoside 4/8 mg | |
| 191 | Tablets | Aceclofenac 100 mg + Paracetamol 325 mg + Trypsin Chymotrypsin 50,000/1,50,000 units | |
| 192 | Tablets | Aceclofenac 100 mg + Thiocolchicoside 4/8 mg | |
| 193 | Tablets | Aceclofenac 100 mg + Drotaverine HCL 80 mg | |
| 194 | Tablets | Baclofen 10/25 mg | |
| 195 | Capsules | Celecoxib 100/200 mg | |
| 196 | Tablets | Dexketoprofen 25 mg + Thiocolchicoside 4 mg | |
| 197 | Tablets | Dexketoprofen 25 mg + Paracetamol 325 mg | |
| 198 | Tablets | Diclofenac Sodium 50 mg + Thiocolchicoside 4/8 mg | |
| 199 | Tablets | Etodolac 300 mg | |
| 200 | Tablets | Etodolac 300/400 mg + Thiocolchicoside 4 mg | |
| 201 | Tablets | Etoricoxib 60/90/120 mg | |
| 202 | Tablets | Etoricoxib 60/90 mg + Paracetamol 325 mg | |
| 203 | Tablets | Etoricoxib 60 mg + Thiocolchicoside 4/8 mg | |
| 204 | Tablets | Etoricoxib 60 mg + Tolperisone 150 mg | |
| 205 | Capsules | Flupirtine Maleate 100 mg | |
| 206 | Tablets | Flupirtine Maleate 100 mg | |
| 207 | Tablets | Ibuprofen 400/600 mg + Thiocolchicoside 4 mg | |
| 208 | Tablets | Ketoprofen 50/100 mg + Thiocolchicoside 4/8 mg | |
| 209 | Tablets | Ketoprofen 100 mg | |
| 210 | Tablets | Lornoxicam 4/8 mg + Thiocolchicoside 4/8 mg | |
| 211 | Tablets | Lornoxicam 4/8/16 mg | |
| 212 | Tablets | Lornoxicam 4/8 mg + Paracetamol 325 mg | |
| 213 | Tablets | Meloxicam 15/30 mg | |
| 214 | Tablets | Naproxen 250/500/550 mg | |
| 215 | Tablets | Naproxen 250/500 mg + Domperidone 10 mg | |
| 216 | Tablets | Sumatriptan 25/50/100 mg | |
| 217 | Tablets | Sumatriptan 50/85 mg + Naproxen 275/500 mg | |
| 218 | Capsules | Thiocolchicoside 4/8 mg | |
| 219 | Tablets | Thiocolchicoside 4/8 mg | |
| 220 | Tablets | Thiocolchicoside 4 mg + Diclofenac Potassium 50 mg | |
| 221 | Tablets | Tolperisone 150 mg + Etodolac 400 mg | |
| 222 | Tablets | Trypsin 48/96 mg + Bromelain 90/180 mg + Rutoside Trihydrate 100/200 mg | |
| 223 | Tablets | Trypsin 48 mg + Bromelain 90 mg + Rutoside Trihydrate 100 mg + Aceclofenac 100 mg | |
| 224 | Tablets | Trypsin 48 mg + Bromelain 90 mg + Rutoside Trihydrate 100 mg + Diclofenac Potassium 50 mg | |
| 225 | Tablets | Trypsin 48 mg + Bromelain 90 mg + Rutoside Trihydrate 100 mg + Diclofenac Sodium 50 mg | |
| 226 | Tablets | Trypsin-Chymotrypsin 50,000 units + Bromelain 90 mg + Rutoside Trihydrate 100 mg | |
| 227 | Tablets | Trypsin Chymotrypsin 1,00,000/2,00,000 units |
NSAID Combinations
These are the non-steroidal drug molecules.
These are the drugs that relieve inflammation.
It is used to treat pain, swelling.
The Uses of NSAIDs
It relieves pain and swelling.
- • Arthritis
- • Muscle aches
- • Back pain
- • Period pain
- • Dental pain
- • Fever
- • Gout
- • Post-operative pain
- • Clot prevention
The Working of NSAIDs
It blocks the prostaglandins. The prostaglandins cause –
- • Nerve pain.
- • Reduces inflammation.
- • Dilation of blood vessels.
- • Leads to increased temperature
The Types of NSAIDs
Non-selective NSAIDs- They inhibit the two -
COX-1 and COX-2 enzymes.
These drugs inhibit prostaglandin synthesis.
It lowers the pain.
It reduces inflammation.
Examples-
- • Ibuprofen
- • Naproxen
- • Diclofenac
Selective NSAIDs-
These are the COX-2 inhibitors.
It inhibits pain and inflammation.
They do not have GIT side effects.
Examples -
- • Meloxicam
- • Indomethacin
- • Piroxicam
Common Side-effects of NSAIDs
The long-term use of NSAIDs increases the risk of GIT bleeding.
It includes GIT side-effects-
- • Indigestion
- • Stomach pain and cramps
- • Stomach ulcers
Cardiovascular disease risk-
- • Heart failure
- • Blood clots
Kidney side-effects - Fluid retention
Why Use NSAIDs Combinations?
The NSAIDs are widely used in combination to-
- • It offers more potent control over pain.
- • It offers a lower dosing of a single drug.
- • It reduces the frequency of doses.
- • It reduces the need for opioid drugs.
The Commonly Used NSAIDs Combinations
The NSAIDs are combined with other drug classes-
Acetaminophen – It is an anti-inflammatory drug. It has more efficient pain control.
Spasmolytic Agents – They relax the smooth muscles in the intestine and uterus.
Opioids – They are added to relieve severe pain during trauma or an accident.
Proton Pump Inhibitors – These relieve GIT side-effects.
Muscle Relaxants – They reduce skeletal muscle spasm. It reduces inflammation and pain.
Antihistaminics – They are added as an adjuvant to NSAIDs to induce sleep or control allergic reactions.
Aprazer Healthcare – The Leader in the NSAIDs Drug Market
Aprazer Healthcare manufactures a wide variety of NSAIDs and their combinations.
Equipped with modern manufacturing infrastructure.
We manufacture top-quality NSAID combinations that are highly effective and affordable.
We are the largest NSAID drug exporters from India.
Exporting the highest quality pharmaceutical products, Aprazer Healthcare is the top NSAIDs drug exporter to Africa, Southeast Asia.
Our Product Portfolio Consists of Top-quality Nsaids Combinations
Etodolac + Thiocolchicoside Tablets - They relieve pain and muscle spasm. It is widely used in muscle strains.
Etoricoxib and Paracetamol Tablets – They relieve arthritis pain.
Trypsin + Bromelain + Rutoside Trihydrate - It is used to treat inflammation, swelling, and pain.
It is widely used for –
- • Arthritis pain
- • Muscle pain
- • Back pain
- • Post-surgery pain
- • Trauma
Conclusion
NSAIDs are widely used as over-the-counter drugs. These are used for headache, muscle pain, and toothache, etc.
It should be used cautiously to prevent the –
- • Risk of cardiovascular problems
- • Kidney damage.
They show potential drug interactions. They should be used cautiously with other drugs.
FAQ
A Widely Used Drug for Dental Pain. Which is It?
• Ketoprofen 100 mg tablets
• Ketoprofen 50/100 mg + Thiocolchicoside 4/8 mg tablets
Does Long–term NSAIDs Use Cause Kidney Damage?
Increases the risk of kidney damage.
NSAIDs Trigger Asthma. How?
• Anti-inflammatory agent.
• It reduces allergic reactions.
What Are the Serious Side Effects of NSAIDs?
• Gastrointestinal bleeding
• Stomach pain
• IBS
The Top Quality NSAIDs Used for Migraine?
Sumatriptan 25/50/100 mg tablets.
