Cisplatin Injection
Aprazer Healthcare is a Cisplatin Injection Manufacturer, Exporter & Supplier in India, manufacturing oncology medicines for hospitals, distributors and global markets.
Available finished formulation under our brand name Cycokast-50.
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Comprehensive Medical Overview
Cisplatin
Classification: Anticancer medicine
What is Cisplatin?
Cisplatin is a platinum-based chemotherapy medicine.
It is given intravenously as a slow IV infusion.
It remains a cornerstone of chemotherapy.
It is widely used to treat solid tumors and other malignancies.
Cycokast 50 is a cisplatin 50 mg/50mL injection, manufactured by Aprazer Healthcare.
Aprazer Healthcare manufactures global standard oncology drugs.
We specialize in manufacturing oncology orals and injectables.
As a WHO-GMP certified manufacturer, we are a recognized drug exporter from India.
We manufacture products to meet global quality standards.
What are Cisplatin injection uses?
It is used to treat different types of cancers and solid tumors.
It may be used alone or in combination with other drugs.
It is approved to be used in –
• Testicular cancer
• Ovarian cancer
• Bladder cancer
Off-label oncology uses –
• Head and neck cancers
• Breast cancer
• Gastrointestinal cancer
• Certain pediatric cancers
• Certain thoracic cancers
How does Cisplatin work?
It binds to the DNA bases in the cells and forms cross-links.
It inhibits DNA replication.
This leads to cell death.
What are the side effects of Cisplatin?
Cisplatin affects both normal and cancer cells.
It suppresses the bone marrow, and the WBC reaches its lowest point (nadir) around 18- 23 days after the infusion.
Common side effects include –
• Gastrointestinal issues
• Persistent fatigue
• Thinning hair or hair loss
• Irritation at the site of infusion
• Nephrotoxicity
• Ototoxicity
• Peripheral nerve damage
• Nausea/vomiting
• Myelosuppression
• Hypersensitivity
Precautions to be followed while using Cisplatin injection-
1. Adequate hydration is required before and after infusion.
It prevents dehydration and renal injury.
2. Cisplatin may cause irritation at the injection site. The infusion site must be carefully monitored.
3. Cisplatin is cytotoxic; avoid spilling onto clothes or coming into contact.
4. Drink enough fluids to prevent kidney damage.
5. The patient must avoid coming into contact with infection, as cisplatin suppresses the immune system by lowering WBC count.
6. Effective birth control barriers should be used, as cisplatin harms the fetus.
Conditions that require cisplatin dose regulation –
Renal dysfunction – Cisplatin is highly nephrotoxic. The dose should be regulated in people with kidney disorder.
Myelosuppression – Cisplatin causes a severe drop in blood counts.
The treatment is usually given in cycles.
Ototoxicity – The patient should be monitored for hearing impairment.
Severe peripheral neuropathy – It can cause severe numbness and a burning sensation in hands and feet.
Drugs that interact with Cisplatin-
Cisplatin adversely affects the kidneys, bone marrow, or the ears.
Combining with drugs having similar toxicities may cause severe effects.
1. Drugs that increase risk of renal toxicity:
• Aminoglycosides
• NSAIDs (painkillers)
• Certain antiviral drugs
2. Drugs that increase the risk of ototoxicity:
• Loop diuretics
• Aminoglycoside antibiotics
3. Cisplatin must be avoided with anticonvulsant drugs.
4. Live vaccines must be avoided due to a weakened immune system.
5. Cisplatin may interact with other cytotoxic and nephrotoxic drugs.
Warnings associated with Cisplatin Injection:
Cisplatin must be administered under medical supervision only.
It must be monitored for organ toxicity and allergy:
• Nephrotoxicity
• Ototoxicity
• Severe bone marrow suppression
• Severe nausea /vomiting
• Severe allergic reaction
It may harm the fetus. Pregnancy must be evaluated before use.
It is not used in breastfeeding.
FAQ
Frequently Asked Questions
Why must alcohol not be used while on cisplatin therapy?
It may increase dehydration or nausea.
Why is it advised to administer fluids with Cisplatin therapy?
Cisplatin causes severe renal damage.
The fluids are administered to prevent excessive dehydration and renal injury.
How to administer Cisplatin injection?
It must be administered as a slow IV infusion only.
Aluminum IV sets or needles must not be used. Aluminum forms precipitates when combined with cisplatin.
What is the peripheral neuropathy effect caused by cisplatin?
It is nerve damage caused by platinum-based drugs.
It causes numbness/tingling in the hands and feet.
How long must contraception be managed after finishing the treatment?
Contraception must be maintained for 11-14 months after the final dose.
How to store Cisplatin injection?
The vial must be stored at controlled room temperature.
It must be protected from light.
Do not freeze the vial.
The leftover solution/used articles must be discarded.
Which is the Cisplatin injection manufacturer in India?
Aprazer Healthcare is a recognized oncology injectables manufacturer.