Crizotinib Capsules
Crizotinib Capsules Manufacturer – Leading WHO-GMP certified manufacturer and global exporter of Crizotinib Capsules (Crizokast). High-quality, reliable, affordable medicine.
Formulation Insights
Comprehensive Medical Overview
Crizotinib
Classification: Anticancer medicine
What is crizotinib?
It is a targeted-therapy anticancer drug.
It is used for the treatment of ALK-positive or ROS1-positive non-small cell lung cancers.
Crizokast, manufactured by Aprazer Healthcare, is prescribed globally and trusted by doctors.
It contains crizotinib 250 mg.
Aprazer Healthcare is an oncology drug manufacturer.
We are a global exporter of oncology medicines from India.
We hold WHO-GMP and EU-GMP certifications.
Focused on delivering affordable healthcare, we continue to invest in advanced technology and new drug development.
What are the uses of Crizotinib?
It is used in specific cancers -
• ALK-positive advanced non-small cell lung cancer
• ROS1-positive advanced NSCLC
• Systemic ALK-positive anaplastic large-cell lymphoma (ALCL)
• ALK-positive unresectable inflammatory myofibroblastic tumour (IMT)
Crizotinib capsule works by -
It inhibits the tyrosine kinase enzymes and blocks ALK and ROS1 signaling.
It blocks the signaling pathways for cancer cell growth.
It stops cell proliferation and growth.
What are Crizotinib side effects?
It causes –
• Vision changes
• Nausea, diarrhea, vomiting
• Fluid retention
• Fatigue and dizziness
• Nerve tingling
Side effects that need careful monitoring-
• Liver toxicity
• Interstitial lung disease/pneumonitis
• QT prolongation
• Severe visual impairment or vision loss
Red flag symptoms –
• New or worsening cough
• Shortness of breath
• Yellowish skin, eyes
• Dark urine
• Fainting spell
• Irregular heartbeat
Crizotinib precautions-
Do not dissolve or open the capsule; it should be taken whole.
It can impair alertness in some individuals; any physical work must be performed cautiously.
Signs of infection/fever must be reported to the doctor.
Any pre-existing condition must be reported to the doctor.
• Heart issues
• Liver disorders
• Chronic lung issues
• Severe kidney impairment
• Vision problems
What must be avoided with Crizotinib?
Drugs that increase crizotinib levels in the blood.
• Azole antifungal drugs
• Macrolide antibiotic drugs
• Protease HIV inhibitors
• Food supplements
Drugs that increase clearance of crizotinib
• Certain anticonvulsant drugs
• Anti-tubercular drugs
• Herbal supplements
What are the Crizotinib drug warnings?
It is contraindicated in patients with an allergy to the drug/excipients
It harms the fetus; it is avoided in pregnancy.
It is not recommended to be used while breastfeeding.
FAQ
Frequently Asked Questions
Why is it advised to avoid pregnancy?
It may cause fetal harm.
Does hair loss occur in all patients?
Alopecia affects specific people only.
How does it affect vision?
Visual disturbances may occur during the initial weeks of treatment.
Persistent/severe vision changes require immediate intervention.
Can I undergo dental surgeries while using crizotinib?
Inform the doctor before any treatment.
Which are affordable crizotinib capsules?
Crizokast, manufactured by Aprazer Healthcare, is highly affordable.