Lenvatinib Capsules
Aprazer Healthcare is a WHO-GMP certified manufacturer and exporter of Lenvatinib Capsules (Lenvakast 4mg, 10mg). Global standard quality for Thyroid, Liver, and Kidney cancer.
Formulation Insights
Comprehensive Medical Overview
Lenvatinib
Therapeutic Classification: Anticancer medicine
What is Lenvatinib?
It is a targeted cancer therapy drug.
It is a widely used drug regimen in oncology care settings.
Lenvakast, Lenvatinib (10 mg, 4 mg), manufactured by Aprazer Healthcare, is a globally available, affordable Lenvatinib formulation.
Aprazer Healthcare is a drug manufacturer/exporter.
We are an exporter of oncology medicines from India.
As a WHO-GMP-compliant pharmaceutical manufacturer, we supply global standard drugs.
We are a bulk medicine supplier to hospitals and clinics.
What is Lenvatinib used for?
It is used for the treatment of:
• Radioactive Iodine-Refractory Differentiated Thyroid Cancer
• Hepatocellular carcinoma
• Renal cancer in combination with Pembrolizumab or Everolimus
• Endometrial cancer
How does Lenvatinib work?
It blocks the protein on the tumor cells.
It inhibits the formation of new blood vessels.
By stopping the supply of essential nutrients and oxygen, it leads to starvation of cancer cells.
It shrinks the tumor size.
What are the important considerations for the use of Lenvatinib?
Use birth control measures; It causes birth defects in the fetus.
It impairs alertness; avoid self-driving.
Take the capsule as a whole; it is toxic in nature.
Avoid touching the inner contents of the capsule.
Dental examination must be done prior to any dental procedure.
Lenvatinib causes osteonecrosis of the jawbone.
It must be monitored when used in people with -
• Preexisting cardiovascular issues
• Impaired liver/kidney functions
• The elderly above 65 years of age.
What are the Lenvatinib drug side effects?
Common side effects –
• Hypertension in 70 percent of people
• Protein leakage in the urine
• GIT disturbances – Nausea, vomiting, etc.
• Skin rashes
• Thinning of hairs
The serious symptoms that require immediate medical care -
• Hypertensive crisis
• Severe bleeding
• Thromboembolism /heart attack
• Gastrointestinal perforation (acute pain in the stomach)
• Neurological dysfunction
Functions that must be monitored with the use of Lenvatinib:
• Blood pressure
• Cardiac functions
• Kidney functions
• Thyroid functions
• Electrolytes
• Liver functions
• Pregnancy status
• Dental/jaw exam
• Proteinuria
Why must the use of other drugs be avoided or monitored with Lenvatinib?
It must be used cautiously with drugs that cause QT prolongation.
• Macrolide and fluoroquinolone antibiotics
• Azole derivative antifungal drugs
• Antiemetics ( 5-HT3 receptor antagonist)
• Antipsychotic drugs
The drug combinations that may increase bleeding risk-
• Warfarin/Heparin
• Aspirin
• OTC painkillers (NSAIDs)
The drugs that alter Lenvatinib metabolism-
• Carbamazepine /phenytoin
• Rifampin
• Antiviral protease inhibitors
• Clarithromycin
• Ketoconazole
FAQ
Frequently Asked Questions
Can I safely consume alcohol while on Lenvatinib therapy?
Minimize or avoid alcohol intake.
It increases the workload on the liver.
Lenvatinib has caused me to lose hair; will it recover?
It causes mild hair loss and hair thinning.
It is not permanent hair loss.
Why is it advised to avoid sun exposure?
It increases skin sensitivity.
Can Lenvatinib cause chemo brain?
Lenvatinib affects thyroid secretion.
It leads to cognitive changes.
Why is there froth in my urine?
The drug affects the kidneys.
It can lead to leakage of proteins in the urine.
It must be reported to the doctor.
Who is the certified oncology drug manufacturer or exporter?
Aprazer Healthcare manufactures WHO-GMP standard drugs.