Anti-Retroviral Combination

Anti-Retroviral Combination

These are the drugs used to treat HIV infection.

HIV infection is caused by a virus.

The Antiretroviral Drugs

• • It inhibits viral replication and multiplication.
• • It lowers the viral count to undetectable levels.

Why Anti-retroviral Combination Drugs?

They are also known as fixed-dose drugs.

It consists of two or more drugs. It is made to be used as a single-dose regimen.

The two potent drugs are combined.

It offers a synergistic effect. It inhibits viral replication at multiple stages.

The combination of antiretroviral significantly lowers the viral count.

It offers better patient convenience.

It reduces the frequency of multiple doses.

It prevents drug resistance.

The Top Antiretroviral Combinations

• • Tenofovir Disoproxil Fumarate, Emtricitabine Tablets- Temirazer
• • Abacavir and Lamivudine Tablets- Abakast-L
• • Tenofovir Disoproxil Fumurate, Emtricitabine, and Efavirenz Tablets- Virarazer

Aprazer Healthcare – The Anti-retroviral Drug Manufacturer

Aprazer Healthcare is an Indian pharmaceutical company renowned worldwide.

Manufacturing a range of anti-retroviral drugs, we are the top HIV medicine manufacturer from India.

We manufacture an exclusive range of antivirals. It includes –

• • Direct-acting antivirals
• • Anti-retroviral drugs

We manufacture global quality drugs and are the top antiretroviral drug exporters.

We export anti-retroviral combinations to Africa, America, and Southeast Asia.

With a focus on affordability and accessibility. We manufacture a wide range of –

• • Generic anti-retroviral drugs
• • Advanced drug treatments
• • Fixed-dose antiretroviral combinations

Investing in drug development and research, we aim to invent new molecules and new combinations to bring effective results.

We have multiple manufacturing units in India.

We leverage cost-effective technology. We are aligned with the highest healthcare standards.

Collaborating with pharmaceutical giants, we bring together diverse expertise and resources.

The Different Types of Anti-retroviral Drugs

• • Reverse transcriptase inhibitors- they inhibit the conversion of viral RNA to DNA.
• • Protease inhibitors- They inhibit the viral DNA strand separation and chain elongation.
• • Integrase inhibitors- They inhibit the viral cell from producing copies or infecting human DNA.
• • Entry and fusion inhibitors- They inhibit viral cell entry into human cells.

What Are the New Generation Anti-retroviral Combinations?

• • Dolutegravir and Lamivudine tablets
• • Dolutegravir, Tenofovir Disoproxil Fumarate, and Lamivudine tablets
• • Tenofovir Alafenamide, Emtricitabine, and Dolutegravir tablets

The Benefits of Anti-retroviral Therapy in HIV

HIV is a life-long disease. It is manageable with the anti-retroviral drugs.

HIV treatment is required lifelong.

The virus severely affects the immune system. It lowers immunity.

The anti-retroviral drugs suppress the virus.

It enhances the immunity.

It prevents disease progression to AIDS.

It reduces complications like the risk of infections, etc.

The anti-retroviral drugs reduce the viral count to undetectable levels.

It inhibits its transmission.

What Are the Long–term Side Effects of Antiretroviral Drugs?

• • Heart disorders – They increase cholesterol levels. It elevates triglycerides.
• • It also leads to insulin resistance.
• • It increases the risk of heart dysfunction.
• • Damage to the kidney - It can cause acute kidney injury. The drug accumulates in the nephrons.
• • It leads to a decline in the absorption of minerals by the kidneys.
• • Liver damage – The antiretroviral drugs cause liver injury. It leads to liver inflammation.
• • The risk increases in hepatitis infections.
• • Bone loss – It leads to bone weakening, osteoporosis. It causes an imbalance in new bone cell formation and bone cell degeneration.
• • Loss of body mass – The older drugs lead to inappropriate distribution of body mass.
• • It is less with the newer drug therapies.

Conclusion

The antiretroviral therapy is widely used in HIV treatment.

It lowers the transmission risk.

It is required to adhere to the treatment.

It requires lifelong therapy.