Xgraf 2

Xgraf 2mg

Composition: Tacrolimus – 2mg

Classification: Transplant Medicine

Xgraf: Long-term Transplant Survival

Xgraf is widely used and highly prescribed for post-transplant care to rapidly suppress the immune system, promoting organ acceptance and long-term graft survival.

Aprazer Healthcare: Advancing Kidney Transplant Care

Aprazer leads the way in manufacturing world-class nephrology medicines and is the largest exporter of kidney transplant medicine.

• • World-class manufacturing Infrastructure
• • International Quality Standards – WHO-GMP certified
• • Affordable Medicines
• • Research-driven formulations
• • Available in 50+ countries

What is Xgraf?

Xgraf is an organ transplant medicine, widely used to reduce the immune reaction to the grafted organ.

Uses of Xgraf

• • Prophylaxis for organ transplant
• • Post-transplant therapy – Kidney, Liver, Heart transplant

How does Xgraf work?

It reduces the immune activity of T-cells, thus lowering the immune response to the transplanted organ.

Benefits

• • Faster onset and rapid suppression
• • Strong immune-suppression
• • Long-term graft survival

Common Side Effects

• • High blood pressure and high potassium levels
• • Tiredness
• • Excess hair growth
• • GIT upset – diarrhea, nausea
• • Headache

Serious Side Effects

• • Kidney damage – reduced urine output, increased creatinine
• • Neurological side effects – Seizures, confusion
• • Liver dysfunctions – Jaundice, yellowish urine, and skin
• • Severe infections
• • Heart complications – QT prolongation, irregular heartbeat
• • Metabolic dysfunction – onset of diabetes mellitus
• • Long-term immune suppression

Precautions

To be used cautiously used in-

• • Elderly Patients
• • Bleeding disorders
• • Liver disorders
• • Kidney diseases
• • Active infections – HIV, Hepatitis
• • Diabetics
• • Hypertension patients
• • Neurological disorders
• • Electrolyte imbalances

Safety Instructions

• • Maintain contraception during the treatment
• • Avoid live vaccines (MMR, Varicella) due to a compromised immune system

Contraindications

• • Should not be used in pregnant women and breastfeeding mothers
• • Hypersensitivity or allergic reaction to the drug or its excipients

Warnings

To be used under medical prescription.

Drug Interactions

• • Antiviral
• • Antibiotics
• • TB medicines
• • Other immune suppressants
• • Cardiovascular drugs – calcium channel blockers
• • Antifungal
• • Grapefruit juice

Important Monitoring Considerations

Monitor for –

• • Total blood count
• • Liver and kidney functions
• • Neurological functions
• • Blood pressure, blood glucose
• • Cardiac functions
• • Therapeutic Drug Monitoring is required as it has a narrow safety margin