The Emerging Role of Metformin in Cancer – Its Future Lies in Precision Medicine

Metformin is the commonly used drug for type-2 diabetes.

The diabetic patients using metformin have shown lower incidences of cancer.

It is widely gaining popularity for its repurposed drug effect.

It is not considered or acclaimed as a standard treatment for cancer.

However, it shows a significant effect in people with metabolic issues. Like – insulin resistance.

It can be a targeted tool for precision medicine.

It can be used against a specific type of population or specific tumors.

The role of metformin in diabetes control-

It inhibits glucose synthesis in the liver.

It increases insulin sensitivity.

It improves glucose uptake and utilization.

It reduces glucose absorption in the intestine.

Metformin role in cancer treatment – 

Metformin is repurposed in oncology for its potential benefits –

• Lowering cancer risk
• Improved survival rates

It stops the growth signal to the tumor cells.

It inhibits fuel supply to the cancer.

It enhances the T-cell and CD4 + cell activity.

It lowers the spread of cancer cells.

It inhibits protein and lipid synthesis in the tumor.

It inhibits inflammatory kinases.

The metformin use in various cancers- 

Breast Cancer – It reduces the risk of hormone-sensitive cancer in diabetic women.

Gastric cancer- It slows down cancer cell proliferation.

Colorectal cancer– It reduced the recurrence of precancerous adenomas.

Liver cancer – It reduces the risk of bile duct cancer.

It reduces the progression of fatty liver to liver cancer.

Ovarian cancer- It reduces the resistance to chemotherapy drugs.

It targets cancerous stem cells.

Pancreatic cancer –It kills the pancreatic cancer cells.

How will metformin be used in cancer treatments in the future?

Metformin is the new hope for cancer patients.

It can be used in people resistant to traditional chemotherapy drugs.

It is an attractive and affordable option for cancer cure in the future.

Bottom line – 

It cannot work as a replacement for chemotherapy.

It may be used as an adjuvant therapy in a specific group of patients.

Aprazer Healthcare – Generic Anticancer Drug Manufacturer 

Aprazer Healthcare, with its leadership in pharmaceutical drug manufacturing, is the largest drug manufacturer.

With the strongest portfolio in anticancer therapy, Aprazer Healthcare manufactures a comprehensive range of generic anti-cancer medicines.

We possess world-class infrastructure supporting R&D.

We continue to invest in advanced drug development and discovery.