Benign Prostatic Hyperplasia (Enlarged Prostate) – Treatment /Drugs

Enlarged prostate is a condition in which the prostate cells grow in size.

Benign growth of prostate cells is not cancer.

The prostate cells in the gland grows in size.

It increases pressure on the bladder.

It blocks the urine flow.

It affects 50% of men by the age of 60.

90% of men over 85 years of age tend to develop an enlarged prostate.

Benign prostatic hyperplasia symptoms – 

• Frequent urination
• Waking up multiple times for urination at night.
• Weak /slow urine
• Trouble urinating
• Dribbling at the end of urination

Benign prostatic hyperplasia causes – 

BPH is linked to unknown causes.

With age, the hormone production in the body is reduced.

Testosterone levels fall while the DHT remains high.

It leads to overproduction of prostate cells.

What are the risk factors for developing BPH?

Age – The risk of prostate enlargement increases after the age of 40.

Genetics – A close family member having an enlarged prostate increases the risk.

Metabolic syndrome- It is linked to altered metabolism.

• Increased BP
• High blood sugars
• High cholesterol
• Cardiovascular diseases
• Type-2 diabetes

Erectile dysfunction – The changes in the muscles /blood vessels in the prostate.

It increases the risk of developing prostate complications.

 

Can BPH progress to cancer?

Benign prostate enlargement does not progress to cancer.

It is the growth of normal, healthy cells.

Benign cells do not travel to other parts of the body.

Cancer is related to abnormal cell growth.

Cancerous cells rapidly spread to other parts.

What are the drugs used in BPH? 

Alpha blockers – They relax the smooth muscles.

They facilitate urine flow.

Tamsulosin and Silodosin

5-alpha-reductase inhibitors – These drugs shrink the prostate cells.

They inhibit dihydrotestosterone hormone expression.

This reduces prostate cell formation.

Dutasteride and Finasteride

PDE-5 inhibitors – These relax the bladder and the urinary tract muscles.

These help manage BPH symptoms.

Tadalafil

Anticholinergics – 

With the growing prostate, the bladder muscles become overactive.

It leads to a sudden increase in urge.

It also causes urine incontinence.

Anticholinergic trigger involuntary contractions.

Solifenacin /Mirabegron

Aprazer Healthcare – A Pharmaceutical Manufacturer

Aparzer Healthcare is a global pharmaceutical company.

We are a top drug manufacturer and exporter from India.

Targeting men’s health, we manufacture a wide range of –

• Erectile dysfunction medicine
• BPH medicines

We are trusted for our specialty drug portfolio and quality drug production.

We have WHO-GMP /EU-GMP certified production facilities.

Offering complete regulatory support and quality compliance, Aprazer Healthcare is trusted worldwide.