Tenofovir Disoproxil Fumarate, Emtricitabine & Efavirenz Tablets
Aprazer Healthcare – Leading WHO-GMP certified manufacturer and global exporter of Tenofovir Disoproxil Fumarate, Emtricitabine & Efavirenz Tablets (Virarazer). High-quality, reliable, affordable medicine.
Available finished formulation under our brand name Virarazer.
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Comprehensive Medical Overview
Tenofovir Disoproxil Fumarate, Emtricitabine & Efavirenz Tablets
Classification: Antiretroviral combination
What is the tenofovir disoproxil fumarate, emtricitabine and efavirenz combination?
It is an antiretroviral drug combination used to treat HIV-1 infection.
The three drugs are combined to provide significant suppression of the virus.
Virarazer is a fixed-dose combination of tenofovir disoproxil fumarate, emtricitabine & efavirenz.
It is manufactured by Aprazer Healthcare.
Aprazer Healthcare is a pharmaceutical manufacturer, specializing in the manufacturing of antiretroviral combinations and antiviral drugs.
Our specialty product portfolio includes-
• Hepatitis B medicines
• Hepatitis C medicines
• HIV medicines
Tenofovir disoproxil fumarate, emtricitabine, and efavirenz combination uses:
It is used to treat HIV-1 infection.
The combination significantly reduces the viral load.
It is used for long-term management of HIV-1 infection.
Tenofovir disoproxil fumarate, emtricitabine, and efavirenz therapy side effects:
• Nausea
• Vomiting
• Diarrhea
• Stomach pain
• Sleep disturbances
• Skin rashes
Side effects that need medical intervention-
• It may cause severe liver and kidney problems.
• It may reduce bone density in some people.
• Severe skin reaction
• Lactic acid buildup, although it's rare, can be serious
• Severe dizziness may be caused in certain individuals.
Mechanism of action of the tenofovir disoproxil fumarate, emtricitabine, and efavirenz combination:
The combination suppresses the virus at multiple stages of replication.
Tenofovir disoproxil fumarate – It is converted into an active molecule inside the cell.
It inhibits DNA synthesis.
Emtricitabine – It interrupts the process of DNA replication.
Efavirenz – It binds to the reverse transcriptase enzyme.
It inhibits the formation of DNA from RNA.
Important precautions and warnings-
The drug combination may affect kidney function and increase risk of several complications.
Patients must be monitored for-
• Renal function
• Lactic acidosis
• Severe skin reaction
• Bone density
• Dizziness or impaired mental alertness
People with known hypersensitivity to the drug must avoid the medication.
Pregnant women must consult a doctor for its use, evaluating overall health.
The patient must not stop the medicine on one's own.
Tenofovir disoproxil fumarate, emtricitabine, and efavirenz drug interactions-
It must not be used with other HIV medicines with the same drug component.
Efavirenz may alter metabolism of other drugs, increasing or decreasing their concentration.
It includes certain antifungals and anticonvulsants:
• Voriconazole or itraconazole
• Carbamazepine, phenytoin, and phenobarbital
Antitubercular drugs – Rifampicin may reduce efavirenz exposure.
The drug combination that may increase the risk of cardiac issues -
• QT-prolonging drugs
• Clarithromycin
The drugs that may increase the risk of kidney-related issues-
• High-dose NSAIDs
• Antivirals
FAQ
Frequently Asked Questions
Is drinking alcohol safe with this combination?
Alcohol, when combined with the TDF/efavirenz combination, may worsen dizziness.
Can tenofovir disoproxil fumarate, emtricitabine, and efavirenz affect bones?
It may reduce bone mineral density in certain people.
Can I stop the medication when the viral count is reduced to zero?
It must not be stopped without asking the doctor.
Even if the viral count reaches zero, the medicine must be continued.
Can it be used in pregnancy?
It can be used on the doctor's recommendation.
Can it prevent HIV transmission?
An undetectable viral count reduces the risk of transmission.
HIV positive people must not use it as a substitute to prevent sexual transmission.
Which is the HIV medication manufacturer and exporter from India?
Aprazer Healthcare manufactures a generic range of HIV medicines.