Tenofovir Disoproxil Fumarate & Lamivudine Tablets

Tenofovir Disoproxil Fumarate & Lamivudine Tablets

Classification – Antiviral Medicine

What are Tenofovir Disoproxil Fumarate and Lamivudine Tablets?

It consists of two drugs, in fixed proportions.
It is used to treat HIV infections.
It is used in resistant Hepatitis B cases.

Tenofovir Disoproxil Fumarate & Lamivudine Tablet Uses

• • HIV-1 infection
• • Chronic Hepatitis B
• • Prophylaxis for HIV before exposure
• • For HIV prophylaxis after exposure

What Are Tudobest L Tablets?

Tudobest L, manufactured by Aprazer Healthcare, is a potent combination.
Tudobest L is available worldwide.
It provides an affordable HIV/Hepatitis B treatment option.

Aprazer Healthcare – Top HIV Antiviral Manufacturer

Aprazer Healthcare manufactures the finest quality of antivirals.
We manufacture an exclusive range of antiviral medicines for Hepatitis and HIV.
We are the top hepatology and HIV medicine manufacturers from India.
We rank as the top HIV medicine exporters worldwide.

Working of Tenofovir Disoproxil Fumarate & Lamivudine

Both components get incorporated into the DNA bases.
It terminates the chain elongation.
It causes cancer cell death.

Why Tenofovir Disoproxil Fumarate & Lamivudine?

It offers effective viral protection.

• • Potent viral suppression
• • Improves immunity
• • Well tolerated
• • Less frequent dosing
• • Lowers the chances of resistance
• • Delay the disease progression

Tenofovir Disoproxil Fumarate & Lamivudine Side Effects

• • Nausea
• • Vomiting
• • Diarrhea
• • Skin rashes and ulcers
• • Lightheaded ness

Tenofovir Disoproxil Fumarate & Lamivudine Severe Effects

It interferes with enzymes. It causes-

• • Lactic acid accumulation – It is caused by impaired mitochondrial function.
•           • Toxins build up in the blood.
• • Liver dysfunction – It leads to fatty liver. It increases the size of the liver.
•           •  It impairs fat breakdown.
• • Dysfunction of the kidney – It impairs renal functions.
•           •  It is excreted through the kidneys.
•           •  It leads to toxicity.
• • Weakening of the bones – It impairs kidney absorption.
•           •  It leads to loss of minerals. It causes bone weakening.
• • Immune system-mediated response – It causes an improved immune system. It causes an inflammatory response.
• • GIT side-effects – It causes severe pain in the stomach. It can cause pancreatitis.
• • Severe allergic reaction

Tenofovir Disoproxil Fumarate & Lamivudine Should Be Used Cautiously in

• • Kidney disorders
• • Liver disorder
• • Osteoporosis
• • Elderly
• • Pregnant women
• • Breastfeeding women
• • Hepatitis B Co-infections
• • Diabetes
• • Obesity

Important Monitoring Instructions

Carefully watch for –

• • Liver functions
• • Kidney function
• • Bone mineral density
• • Lactic acid levels
• • Viral load and CD4 count

Warnings for Tenofovir Disoproxil Fumarate & Lamivudine Usage

It should be used after a doctor’s prescription.
Do not use therapy in –

• • Liver dysfunction.
• • Allergy to the drug.

Do not discontinue abruptly in Hepatitis B patients
It may cause serious liver flare-ups.

Important Drug Interactions of Tenofovir Disoproxil Fumarate & Lamivudine

Several drugs react with different drugs.
It can lead to toxicity.
It changes the concentration of drugs in the blood.

• • Anticonvulsant drugs
• • Cardiovascular drugs
• • Antihypertensive
• • Anti-fungal and
• • Anti-tubercular drugs

Conclusion

Tenofovir Disoproxil Fumarate & Lamivudine is used worldwide for HIV care.
It should be carefully monitored for

• • Bone weakening
• • Hepatitis B co-infections