Can a Body Reject a Kidney Transplant Despite Taking Anti-Rejection Medications?
The anti-rejection drugs suppress the immune system.
They do not block immune function.
One must clearly understand the risks and early symptoms to prevent long–term damage.
Why does kidney transplant rejection happen?
It is a condition in which the body rejects the transplanted graft.
The immune system responds to external pathogens or agents in the body.
It treats the graft as a foreign body.
It causes an inflammatory response.
Types of kidney transplant rejection:
Hyperacute rejection:
It can occur during the time of transplant.
It is very rare these days.
It occurs mainly due to mismatched tissue, preexisting antibodies, or other incompatibilities.
Acute rejection:
It can happen any time after the transplant.
The immune system suddenly responds to the graft.
Generally, it is treatable if detected early.
Chronic rejection:
It is a slow, progressive rejection.
It is persistent immune-mediated damage.
It can lead to irreversible damage.
It can cause permanent scarring of kidney tissues.
Reasons that may cause kidney transplant rejection:
- Missing medicines:
It may happen if a patient does not take medicines strictly.
Leaving or missing a dose may increase rejection risk.
Drug interactions:
Certain drugs may alter the effectiveness of anti-rejection medicines.
They may reduce or increase drug levels.
- Preformed antibodies:
People having prior blood transfusion, pregnancies, or organ transplant may have sensitized immune system.
They may already have developed antibodies against the graft.
It may sensitize the recipient, causing rejection.
- Other illnesses:
Any infection or illness may activate the immune function.
It can intensify the rejection response.
- Tissue mismatch –
When the donor and the recipient do not have genetic compatibility, the graft may be rejected.
A higher number of tissue mismatches increases the risk of organ rejection.
Within what period after kidney transplant may kidney rejection occur?
Kidney rejection can occur at any point in life.
It can occur within a few minutes to a few hours or can take several months or years.
Early symptoms of kidney transplant rejection:
During the early stages of rejection, the body generally shows no symptoms.
- Sudden weight gain
- Decreased urination
- Edema
- Flu-like symptoms
- Pain or tenderness around the transplant area
- High blood pressure
- Increased serum creatinine levels
- Increased protein in urine
Conclusion:
Kidney transplant rejection can happen even while taking regular medications.
To preserve the graft and to identify rejection earlier, the organ function must be monitored regularly.
The patient must strictly adhere to the treatment.
Aprazer Healthcare – Supporting Kidney Transplant through Affordable Anti-rejection Drugs
Aprazer Healthcare is a nephrology medicine manufacturer.
We specialize in manufacturing a broad range of kidney medicines, including immunosuppressants.
We manufacture affordable anti-rejection drugs to support long-term transplant treatment.
As a third-party manufacturer, we manufacture affordable, regulatory-compliant drugs for different countries.