Abakast-L
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Abacavir and Lamivudine

Classification: HIV medicine

Why Abacavir / Lamivudine?

The two drugs are combined to be effective against the HIV-1 strain. It is used with other drugs and forms a part of highly active therapy (HAART) to suppress the virus.

Uses of Abacavir / Lamivudine Combination

  • • To treat HIV -1 infections
  • • It is taken as prophylaxis treatment after HIV exposure.
  • • Used in Hepatitis B co-infections

Abacavir/ Lamivudine (Abakast-L) Manufactured by Aprazer Healthcare

Abakast-L is widely used against HIV-1 infection; it is highly accepted and prescribed by top leading doctors and healthcare professionals.

Abakast L is readily available worldwide. It offers an affordable treatment for HIV-1 infection.

Why Aprazer Healthcare for HIV Care?

Leading the fight against HIV, Aprazer Healthcare is the top pharmaceutical company manufacturing world-class, WHO-GMP certified HIV antivirals. Aprazer Healthcare, with years of quality manufacturing and global reach, has positioned itself as the leading HIV medicine manufacturer and exporter.

With a significant global presence and robust distribution network, we lead the way in HIV medicine export and distribution.

Working of the Abacavir/ Lamivudine Combination

The working of Abacavir/Lamivudine includes terminating DNA chain elongation and inhibiting viral replication and multiplication. It causes viral death, reducing the viral count.

Benefits of Abacavir / Lamivudine

It reduces the viral count to ineffective levels, lowers complications, and significantly improves the quality of life.

  • • Significantly lowers viral count
  • • Improves immunity
  • • Inhibit transmission
  • • Delays disease progression

Abacavir / Lamivudine Caused Side Effects

The abacavir and lamivudine combination causes mild side effects that are tolerable and easy to manage. Usually the side effects fade away with time.

  • • Nausea
  • • GIT upset
  • • Reduced appetite
  • • Insomnia
  • • Diarrhea
  • • Skin rashes

Serious Side Effects Caused by Abacavir / Lamivudine

Allergy or Hypersensitivity – The key side effect is an allergic reaction to the drug components. It would cause immediate fever, redness, a racing heart, and rash.

Other rare side-effects:

  • • Liver Damage – It increases the size of the liver and causes liver toxicity.
  • • Lactic acid – Lactic acid builds up in the blood, which causes shortness of breath, skin discoloration.
  • • Vigorous immune response – It activates the immune system to fight infection and causes a severe body response.
  • • Hepatitis B flare-up – During strong immune activity, it can cause Hepatitis B to show up again in Hepatitis B co-infections.

Precautions While Using Abacavir / Lamivudine

To be used cautiously in people with –

  • • Liver disorders
  • • Co-infections
  • • Kidney impairment
  • • Cardiovascular disorder
  • • Alcohol use due to liver toxicity
  • • Pregnant and breastfeeding women

When not to be used – Abacavir and lamivudine together should not be used in people with severe liver disorders, as they may lead to hepatotoxicity or liver damage. Always check for Hypersensitivity or allergy to drug components.

Warnings

  • • To be used under medical prescription.
  • • Hepatitis B co-infections may cause serious viral flare-ups; do not stop medication immediately.

Important Monitoring Considerations

During the treatment process, it is recommended to regularly check the body functions (liver functions) to prevent hepatotoxicity or severe complications like Lactic acidosis, pancreatitis.

The regular test should include a comprehensive metabolic panel.

  • • Liver function – elevated liver enzymes
  • • Viral loads (HIV, HBV)