Bleomycin Injection

Bleomycin Injection

Composition: Bleomycin 15,000 units

Classification: Anticancer Medicine

What is Bleomycin Injection?

Bleomycin Injection is an anticancer drug that is used in different forms of cancer, ranging from head and neck cancer to testicular cancer.

Uses of Bleomycin Injection

It is a commonly used chemotherapy agent, used to treat-

• • Lymphoma – In both Hodgkin and Non–Hodgkin lymphomas.
• • Squamous tissue Carcinomas – head, neck, penis, uvula
• • Pleural effusion, Malignant
• • Testicular Carcinoma

Bleokey (Bleomycin Injection) – Stronger Cancer Elimination

Bleokey is available worldwide and is extensively used in cancer care centers and hospitals. Bleokey, prescribed by the leading oncologists, is the top cytotoxic chemotherapy drug, used in multiple cancers.

Aprazer Healthcare – Manufacturing the Top Cancer Care Medicines

Aprazer Healthcare is the leading anticancer medicine manufacturer, developing a range of anticancer therapy medicines extending from traditional chemotherapy drugs to advanced targeted therapy medicines.

Aprazer Healthcare is a prominent Indian Pharmaceutical company with a significant share in Indian pharmaceutical exports. We manufacture a global range of generic anticancer medicines and export worldwide, making essential healthcare affordable and accessible to all.

Working of Bleomycin Injection

Bleomycin releases free radicals, which disrupt the cancer cell cycle and inhibit cell division and replication. The free radicals break the cancer cell DNA strands.

Common Side Effects

Bleomycin is toxic and shows both common and serious side effects. The common side-effects are temporary and manageable-

• • Fever and chills
• • Vomiting
• • Weight loss
• • Skin rash and pigmentation
• • Mouth Ulcers
• • Anemia
• • Diarrhea
• • Hair loss
• • Increased liver enzymes

Serious side effects of Bleomycin Injection

A few serious side effects caused by bleomycin injection depend on the medical condition.

• • Allergic Reaction – It can occur immediately upon administration of Bleomycin Injection.
• • Pulmonary Toxicity – At higher doses, it severely affects the lungs, causing toxicity.
• • Dermatitis – Toxicity in the skin, thickening of the skin, causing rashes.
• • Renal Toxicity – It accumulates in the kidney, causing toxicity.
• • Vascular Toxicity – it is the formation of a clot or constriction in small blood vessels.

Precautions while using Bleomycin Injection

It should be cautiously used in people with –

• • Renal Disorders
• • Lung disorders
• • Liver disorders
• • Bleeding disorders

Warning for Bleomycin Injection

• • It can cause an allergic reaction.
• • It should be used only after a doctor’s recommendation.
• • It should not be used in pregnant women and Lactating mothers.

Storage of Bleomycin Injection

The bleomycin injection vial should be stored at a temperature of 2 -8 degrees Celsius.

Administration Instructions

It can be given as intravenous, Intramuscular, or Intrapleural. It should not be mixed with dextrose-containing compounds.

Drug Interactions

Bleomycin shows certain drug interactions and may reduce their effect, losing control over the disease, or it may exacerbate their effects. It reduces the therapeutic effect of –

• • Phenytoin
• • Digoxin
• • Live vaccines
• • Immunosuppressant

Amphotericin B and antifungal medication – It increases the risk of toxicity.

Cisplatin – it causes a cumulative effect.

Important Monitoring Consideration

Due to its toxic effects, Bleomycin injection should be carefully monitored for therapeutic dose adjustments. Regular testing is required for –

• • Total blood count
• • Skin conditions like pigmentation and rash.
• • Mouth sores and ulcers
• • Necrosis at the infusion site
• • Respiratory symptoms
• • Signs of infections