COLIAXIS
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Colistimethate Sodium Injection

Classification: Antibiotic Injection

What is Colistimethate Sodium Injection?

It has a strong bactericidal activity. It is used to treat bacterial infections in critically ill patients.
It is a critical therapy used to treat life-threatening infections and other hospital-acquired infections.

Uses of Colistimethate Sodium Injection

  • • Severe lung infection
  • • Infections resistant to other drugs
  • • Ventilator-associated pneumonia
  • • Meningitis
  • • Blood–stream infections
  • • Severe urinary tract infections

Coliaxis (Colistimethate Sodium Injection) – A Stronger Protection against Infection

Coliaxis (Colistimethate sodium) is manufactured by Aprazer Healthcare.
Available worldwide, it is widely used to treat resistant bacterial infections in hospitals and ICU care settings.
Coliaxis is a strong antibiotic, often used as a last choice in life-threatening infections in critically ill patients.

Aprazer Healthcare – The Top Quality ICU Injections

Aprazer Healthcare is the leading ICU injection manufacturer due to its commitment to quality and affordability.
Our state-of-the-art manufacturing complies with the highest global standards (WHO-GMP, EU-GMP).
We manufacture a wide range of critical care injections, antibiotics, and emergency injections.

With a strong presence in global markets and a reliable international supply chain, Aprazer Healthcare is the top ICU injection exporter worldwide.

Benefits of Colistimethate Sodium Injection

It is used to prevent the spread of infection in a hospital.

  • • Kills harmful bacteria, inhibits transmission.
  • • Used against drug-resistant infections.
  • • Reduce severe endotoxin effects.

How does Colistimethate Sodium Injection work?

It damages the bacterial cell wall, causing the internal organelles to be expelled.
It distorts the integrity, killing the bacteria.

The common side effects of Colistimethate Sodium Injection

The common side effects are temporary and go away with time as the body adjusts to the drug. It includes –

  • • Gastrointestinal upset
  • • Mild rashes or itching
  • • Fever
  • • Blurred vision
  • • Pain at the site of injection

Severe Side Effects of Colistimethate Injection

Colistimethate exhibits a strong antibacterial effect. It severely affects the kidneys and the CNS.

  • • Kidney Damage – Higher doses can lead to toxicity in the kidneys, altering kidney function.
  • • Nerve Damage – Strong toxic build-up of the drug affects nerves, causing muscular weakness affecting ocular and respiratory muscles.
  • • Severe Allergic Reaction – Any reaction with the drug components can cause an immune reaction, severe skin rash, difficulty in breathing, etc.
  • • Severe Diarrhea – Large watery stools may occur as the toxic doses disrupt the gut flora.

Precautions while using Colistimethate Injection

To be cautiously used in people with –

  • • Kidney Disorder – It can cause renal toxicity and severely damage the kidneys.
  • • Muscular and Respiratory Disorder – It affects the nerve conduction and may cause muscular paralysis in pre-existing conditions.
  • • Pregnant or Breastfeeding Women – It may adversely affect the infant or the fetus.
  • • Driving – It causes dizziness and blurred vision; driving should be avoided during the treatment.
  • • Alcohol – Intake of alcohol may cause severe drowsiness.
  • • Elderly and Children – Due to the toxic effect, it requires dose monitoring.

Drug Interactions with Colistimethate Sodium

It may cause harmful effects with drugs that are neurotoxic or nephrotoxic.

  • • Aminoglycosides
  • • Other antibiotics
  • • NSAIDS or other nephrotoxic drugs
  • • Neuromuscular blocking drugs
  • • General anesthetic drugs

Storage

  • • An unconstituted form can be stored at normal temperature.
  • • Reconstituted solution at low temperatures (2-8 degrees Celsius).
  • • Use before 24 hours the diluted form.

Important Considerations for ICU Use of Colistimethate Sodium Injection

Therapeutic Drug Monitoring – It is required for critically ill patients due to altered metabolic functions.
Regularly monitor Plasma drug levels for Dose adjustment and management.
Colistimethate causes dose-dependent nephrotoxicity and nerve damage.
Regularly monitor Kidney functions and Neurological functions.

Administration Methods

Colistimethate is available in the form of powder, which can be administered through inhalation,
and is diluted for IV, IM, or Intrathecal administration.