Dacarbazine Injection

Dacarbazine Injection

Classification: Anticancer Medicine

What is Dacarbazine Injection?

It is an anti-cancer medicine and is widely used in the treatment of lymph and skin cancer.
It is administered intravenously, directly into the systemic circulation by a healthcare professional.

Uses of Dacarbazine Injection

It is effective against various cancers-

• • Skin cancer
• • Hodgkin lymphoma
• • Tissue sarcoma
• • Brain tumors
• • Breast cancer
• • Lung cancer

Dacarzer 200mg – Approved Blood Cancer Medicine

Dacarzer 200mg is widely used in oncology care settings to kill white blood cancer cells. Dacarzer, highly prescribed by leading oncologists, is used to treat advanced cancer and cancers that fail other treatments.

Dacarzer 200mg is manufactured by Aprazer Healthcare. Aprazer Healthcare specializes in top-quality oncology medicines, manufacturing WHO-GMP certified medicines accessible worldwide.

Aprazer Healthcare – Innovating, Successful Anticancer Treatments

Aprazer Healthcare, with a strong focus on innovation and R&D, is the leading pharmaceutical manufacturer,
developing advanced anticancer drugs.

We have a successful anticancer product portfolio, including Chemotherapy, Targeted therapy, and Hormonal therapy anticancer drugs.
With a strong commitment to health equity, we ensure affordable access to essential treatment, and we are the leading anticancer drug exporter to countries and cities globally.

How does Dacarbazine Injection work?

It gets converted by the liver and binds to the cancer cell DNA, destroying and damaging cancer cells. It inhibits its proliferation and multiplication.

Common side effects

Stomach upset is the most common side effect caused by Dacarbazine. It fades with time after the body adjusts to the medicine.

• • Nausea and vomiting
• • Reduced appetite
• • High risk of infection
• • Bruising and bleeding
• • Anemia (low red blood cell count)
• • Photosensitivity

Serious Side Effects

• • The severe and the most common side-effect caused by Dacarbazine is bone marrow suppression. It reduces the formation of platelets and leukocytes. Low blood count increases the risk of infection and bleeding.
• • Other conditions include – Hepatic-toxicity, Risk of Secondary cancers
• • Severe allergic reactions.
• • Dacarbazine causes irritation and pain in the IV vein.

Precautions and Warnings while using Dacarbazine

It should be used in a healthcare setting and after a doctor’s prescription. It harms the infant and the fetus; it must not be used in pregnant and breastfeeding women. Allergy or hypersentivity should be checked before using.

Use cautiously in –

• • Liver or kidney disorders
• • Immune dysfunctions
• • Bone marrow disorders
• • Bleeding disorders
• • Pre-existing GIT disorders

Storage of Dacarbazine Injection

• • Dacarbazine is available in the form of powder.
• • It is reconstituted with saline, dextrose, or sterile water.
• • It should be stored at 2-8 degrees Celsius.
• • Powdered form can be stored unopened at room temperature.
• • Dacarbazine degrades in light; it should be stored in the dark.

Administration Instructions

Dacarbazine is cytotoxic; it should be carefully handled using gloves and should be immediately washed if it comes in contact with skin. It should be administered slowly as an IV infusion. The reconstituted solution should be used immediately.

Important Monitoring Instructions

Administration of Dacarbazine should be carefully monitored for the signs of pain, redness, and irritation at the site of injection. During the therapy, the body functions that should be closely observed –

• • Blood count
• • Liver functions
• • Kidney functions
• • Early signs of infections
• • Necrosis and vein leakage
• • Hydration status

Drug Interactions

Dacarbazine, combined with other anticancer drugs, causes additive myelosuppression. It should not be combined with other drugs that cause additive side effects, like-kidney toxicity, liver toxicity, etc. Avoid anticoagulants, live vaccines, and other photosensitizing drugs.