Fulvestrant Injection
Fulvestrant Injection
Classification: Anticancer Injection
What is Fulvestrant Injection?
It is used in cancer care settings and hospitals.
It is an anticancer injection used for the treatment of breast cancer.
It is a hormone therapy injection.
Where is Fulvestrant Injection Used?
Fulvestrant is used to treat breast cancer in elderly women.
It is used after menopause.
- • HER-2-positive breast cancer
- • HER-2-negative breast cancer
- • Breast cancer is resistant to other therapies.
Why Fulvekast?
Fulvekast is a fulvestrant pre-filled syringe. Fulvekast injectables manufactured by Aprazer Healthcare, is used worldwide as an effective treatment against aggressive breast cancers.
Fulvekast is a pre-filled syringe easy to administer.
It is a precise dose formulation.
Aprazer Healthcare – Precise Anticancer Injections
Aprazer is an anticancer Injection manufacturer based in India. With its significant global presence, Aprazer Healthcare is the largest exporter of cancer injections from India.
We specialize in manufacturing a range of anticancer injections and advanced dosage formulations.
- • Freeze-dried injection
- • Prefilled syringes
- • Single-use vials
- • Ready to use technology injections
Mode of Action of Fulvestrant
It selectively inhibits the estrogen receptors.
Estrogen causes cancer cell growth.
It stops estrogen binding and action.
It stops cancer growth and proliferation.
Why is Fulvestrant Used?
It is widely used when breast cancer develops resistance to other hormone therapy drugs.
It is used as it offers-
- • Longer progression–free survival.
- • Directly downregulate the receptor, offering complete blockade.
- • Has better tolerance and a favorable safety profile.
What Are the Precautions Needed for Fulvestrant Injection?
Fulvestrant should be carefully used depending upon the patient’s health-
- • It can cause an allergic reaction.
- • Bleeding disorders – It lowers blood count, increasing the risk of bleeding.
- • Liver diseases – They affect liver enzyme activity.
- • Elderly patients who are at risk of osteoporosis.
- • People with Vitamin D or Calcium deficiency.
- • It can cause nerve damage at the site of injection.
- • It causes dizziness; avoid driving a vehicle.
What Are Fulvestrant Injection Adverse Effects?
Certain side effects occur at the start of the treatment and can go away with dose adjustments.
- • Sore throat
- • Mouth sores
- • Upset stomach
- • Nausea
- • Loss of appetite
- • Headache
- • Tiredness
- • Hair loss
- • Injection site irritation
- • Painful joints and muscles
What Are Fulvestrant Serious Side Effects?
It reduces Estrogen levels and causes hormonal fluctuation.
Estrogen is responsible for bone health. A reduction in levels increases the risk of fracture.
- • Hepatotoxicity – It is metabolized in the liver. Any liver dysfunction may increase toxicity.
- • Bleeding issues – It reduces platelets. It increases the risk of blood clots. It increases the risk of GIT bleeding, gum bleeding, etc.
- • Severe necrosis – It causes nerve damage at the site of injection.
Important Monitoring Information
Fulvestrant therapy should be carefully monitored for
- • Side effects and toxicity
- • Risk of bleeding
- • Drug interactions
Regularly monitor –
- • Total blood count
- • Hepatic functions
- • Kidney functions
- • Local tissue necrosis
- • Thromboembolic events
What Are the Necessary Warnings for the Use of Fulvestrant?
- • To be used under medical supervision, an oncologist specialist.
- • Allergy or hypersensitivity to the drug components.
- • It should not be used by women feeding their child.
- • It should not be used in expecting women (pregnancy).
How to Store Fulvetsrant Injection?
- • It is to be stored in a refrigerator (2-8 degrees Celsius).
- • It should not be stored in the freezer.
- • Avoid hot temperatures and humidity.
Conclusion
Fulvestrant is used to treat breast cancer in elderly women.
It is used in women after menopause.
