Hydroxyurea Capsules
Hydroxyurea Capsules
Classification: Anticancer Medicine
What is Hydroxyurea?
It is used for the treatment of different types of cancers and also blood disorders.
Uses of Hydroxyurea
It is widely used to treat blood cancers and sickle cell anemia
- • Resistant Chronic Myeloid Leukemia
- • Melanoma
- • Head and neck cancer
- • Sickle cell anemia
- • Thrombocythemia
- • Cancer in the ovaries
What is Aprahydro?
Aprahydro is manufactured by Aprazer Healthcare. It is a global standard anticancer medicine.
Aprahydro is used worldwide for effective treatment of blood cancers.
Aprazer Healthcare – Oncology Medicine Manufacturer and Exporter
As the leading anticancer medicine manufacturer, we develop an exclusive range of top-quality anticancer medicines.
Aprazer Healthcare specializes in manufacturing advanced cancer medicines and a complete range of chemotherapy medicines.
As the largest anticancer drug exporter, we stand at forefront in developing global standard anticancer medicines and anticancer injections.
Working of Hydroxyurea Capsule
As an anticancer agent, Hydroxyurea inhibits cancer cell growth and formation. It inhibits cancer cell DNA synthesis.
It is highly effective in sickle cell anemia as it increases the production of fetal hemoglobin.
Fetal hemoglobin replaces sickle cell hemoglobin.
It also reduces the replication of sickle cell hemoglobin.
Common side effects caused by Hydroxyurea
- • Nausea
- • Vomiting
- • Thrombopenia
- • Fatigue
- • Neutropenia
- • Hair loss
Serious side-effects
The long-term use of Hydroxyurea suppresses the rapid cell division and affects cell formation in bone marrow, skin, and stomach.
Bone marrow suppression – It leads to a decline in blood cell formation, increasing risks for
- • Severe Infection
- • Bleeding
- • Anemia
Skin inflammation and rashes – it can cause painful ulcers on the skin. The ulcers are mainly on the legs and ankles.
Risk of secondary malignancies.
It increases the risk of lung toxicity and infection.
Liver dysfunctions.
Kidney dysfunctions.
Neurological side-effects – Hallucination, dizziness etc.
Warnings
- • It is a prescription drug to be used under medical supervision only.
- • It should not be used in people with an allergy to the drug components.
- • Pregnant ladies
- • Women that are breastfeeding
- • Live vaccines should not be given in treatment.
Precautions while using Hydroxyurea Capsules
To be cautiously used in –
- • Renal insufficient patients
- • Bleeding disorders
- • Liver disorders
- • Kidney disorders
- • Immune-compromised individuals
- • Adjuvant to other therapies – radiation therapy
- • Chronic ulcers
Toxicities
Hydroxyurea causes dose-dependent systemic toxicities.
Bone marrow suppression causing –
- • Thrombocytopenia
- • Leukopenia
Lung toxicity –
- • Shortness of breath
- • Cough, pulmonary fibrosis
Skin toxicity –
- • Rashes
- • Hyperpigmentation
- • Ulcers
- • Ulceration in the mouth
- • Mucositis
Drug Interactions
It shows severe drug interaction and also causes additive effects when used with –
- • Myelosuppressive agents
- • HIV medicines
- • Deferiprone
- • Other radiation therapy
- • Live vaccines
Important safety and monitoring information
Hydroxyurea is generally well tolerated, but requires regular monitoring for –
- • Blood functions
- • Infections
- • Kidney functions
- • Skin changes
- • Liver functions
- • Allergic reactions
It increases sun sensitivity on the skin. Maintain effective contraception.
Conclusion
Hydroxyurea capsules are widely used for cancer treatments. It should be used cautiously in people having HIV or Hepatitis.
It can increase the risk of pancreatitis in HIV patients. It can also lead to false blood test and uric acid levels.
