L-Asparaginase Injection
L-Asparaginase Injection
Composition- L Asparaginase 10000 IU
Classification – Anti-cancer medicine
L-Asparaginase Injection?
It is an anticancer Injection, widely used for blood cancers.
It is a targeted therapy anticancer medicine, it consists of the Asparaginase enzyme.
It is used to achieve complete remission in adults and pediatric patients.
Uses of Asparaginase Injection
- • Lymphoblastic Leukemia
- • Lymphoma
- • Soft tissue cancer
- • Hodgkin’s cancer
Why L-Aprakast?
L- Aprakast is widely used across the world as an effective cancer treatment for various types of blood cancer. L-Aprakast is a widely used anticancer injection in Acute Lymphoblastic Leukemia in children.
Aprazer Healthcare is the leading anticancer injection manufacturer. Renowned worldwide, we are the top manufacturers of advanced anticancer medicines and injections.
Manufacturing lyophilized powders and pre-filled injections, we are the leading exporter of anticancer injections.
Working of Asparaginase Injection
Cancer cells use asparaginase to replicate and multiply.
L-Asparaginase Injection leads to the breakdown of asparaginase in the blood.
It causes Cancer cell starvation.
Apoptosis and cell death.
Common side effects of Asparaginase
L-Asparaginase injection breaks down the formation of the Asparaginase enzyme.
It causes its depletion, and it affects normal body cells.
It induces an immune response or activity to L-Asparaginase.
- • Infection risks
- • Blood clots
- • Diarrheas
- • Weight loss
- • Loss of appetite
- • High albumin levels,
- • Increased bilirubin levels
- • Edema
- • Lowered blood pressure
- • Abdominal pain
Serious Side-effects
L-Asparaginase disrupts protein synthesis.
It increases the load of protein on the liver and pancreas.
- • Pancreatic bleeding
- • Thromboembolism- clots and strokes
- • Bone marrow suppression – thrombocytopenia
- • Shortness of breath
- • Neurological side-effects
Toxicities –
It causes various toxicities in the body, affecting several organs.
- • Hepatotoxicity
- • Thrombosis and bleeding
- • Pancreatic toxicity
- • Hyperglycemia
Warnings-
Not to be used in hypersensitivity to drug components.
It should be avoided in mothers who feed children.
It should be avoided in pregnant ladies.
To be used under medical supervision only,
Do not mix dextrose-containing solutions (incompatibility).
Precautions for L-Asparaginase
To be used cautiously in patients with other medical conditions and ongoing treatments.
- • Heart disease
- • Low blood count
- • Liver disease
- • Pancreatitis
- • presence of an infectious disease
- • Use carefully in elderly people
- • Obese people
Storage:
Store at 2-8 degrees Celsius
Reconstitute the solution just before administration.
Drug Interactions-
It shows several interactions with other chemotherapy drugs and corticosteroids.
- • Methotrexate
- • Vincristine
- • Anti-coagulants
- • Liver-toxic drugs
- • Hepatitis medicines
- • Contraceptives
Important safety and monitoring information
Long-term therapy requires monitoring for –
Pancreatitis and liver toxicity.
Clotting and coagulation.
A complete profile of –
- • Liver functions,
- • Pancreatic enzymes,
- • Blood coagulation,
- • Sugar levels.
Administration Instructions
L-asparaginase Injection is given by slow IV or Intramuscular route.
It is incompatible with Dextrose.
Conclusion-
L-Asparaginase should be used carefully, only in a medical care facility.
It is not for self-administration.
People should maintain effective contraception during the treatment, due to its teratogenic effects.
