Ledipasvir & Sofosbuvir Tablets

Classification – Hepatitis C antiviral medicine

What are Ledipasvir and Sofosbuvir Tablets?

It is an antiviral drug composition approved to treat chronic hepatitis C. It is used against multiple hepatitis C genotypes- 1, 4, 5, 6.

It is a newer antiviral combination.

Ledispasvir and Sofosbuvir Tablet Uses

It is used to treat –

• Chronic Hepatitis C
• Failed Hepatitis C cases
• HIV co-infections

Why choose Ledikast by Aprazer Healthcare?

Ledikast, available worldwide, is the top-quality antiviral drug combination. Ledikast is the global standard hepatitis C medicine, prescribed by leading hepatologists.

Ledikast is widely used in post-liver transplant care to treat Hepatitis C infections.

Aprazer Healthcare – The Leadership in Antiviral Therapies

Aprazer Healthcare leads the way in antiviral drug manufacturing. We are the top Hepatitis C medicine manufacturers. We develop a range of Hepatitis C medicines, Hepatitis B medicines, and HIV medicines.

Manufacturing an affordable range of antivirals, we are the leading hepatitis medicine exporter. Our quality exports include –

• (Ledipasvir, Sofosbuvir) – Ledikast
• (Sofosbuvir, Velpatasavir) – Velakast

Ledipasvir, Sofosbuvir: Adverse Effects

It is the newer antiviral drug combination. It is approved to have fewer severe side effects.

The usual side effects caused are –

• Nausea
• Vomiting
• Diarrhea
• Stomach upset
• Mood upset

Severe Side-effects- Ledipasvir and Sofosbuvir

The side effects created by newer generation drugs are tolerable and less severe.

The most severe side-effect caused is Hepatitis B reactivation.

Other severe side-effects include-

• Pain in the abdomen
• Suppressed heart rate
• Liver failure
• Allergic reaction

Ledipasvir and Sofosbuvir: Working

It consists of two important drugs. It provides effective viral suppression.

Ledipasvir and Sofosbuvir inhibit DNA polymerase and stop viral cell replication.

Benefits

The combination offers a synergistic effect.

It offers potent viral suppression.

It reduces the resistance.

It has better tolerability and safety.

Precautions for Ledispavir and Sofosbuvir

To be used cautiously in patients

• Hepatitis B infections
• HIV infections
• Heart disorders
• Liver disorders
• Pregnant and breastfeeding women
• In children
• Kidney disorders

Warning

• Allergy or hypersensitivity to drug components.
• It should not be used in End-stage renal disease
• Not to be combined with Amiodarone.
• It is a prescription drug to be taken under medical supervision only.
• Not to be combined with ribavirin in pregnancy.

Important Safety and Monitoring Information

The long–term hepatitis C therapy with Ledispavir and Sofosbuvir requires observing signs of reactivation of other infections, like Hepatitis B.

Regular monitoring of –

• Hepatic functions
• Renal functions
• Cardiac functions
• Co-infections, and
• Neuropsychiatric adverse reactions.
• Drug interactions – Ribavirin and Amiodarone
• Not to be used alone for HCV infections.

Drug Interactions

The antiviral combination interacts with other drugs, leading to reduced effectiveness and enhanced side effects.

• Ribavirin
• Antacids
• Rifampin
• Histamine blockers
• Proton pump inhibitors
• Anticoagulant

Conclusion

Ledispavir and Sofosbuvir have a significant effect on viral suppression. It is a combination offering strong protection.

These combinations offer a simpler regimen, better patient compliance.