Oxaliplatin Injection

Oxaliplatin Classification – Anticancer injectionWhat is Oxaliplatin?Oxaliplatin is a platinum-based chemotherapy injection.It is used to treat colorectal cancer worldwide.Oxazer is Oxaliplatin 100mg/50ml manufactured by Aprazer Healthcare.It is a globally available, generic oxaliplatin injection.Aprazer Healthcare is a pharmaceutical manufacturer.We are a global drug exporter, supplying drugs to Asia, Africa, and America.We specialize in manufacturing generic anticancer drugs.Exporting the widest range of generic anticancer drugs, we have a strong reputation in the international markets.What are Oxaliplatin injection uses?It is a widely used chemotherapy injection in –

• Stage-3 colon cancer
• Metastatic colorectal cancer

Its off –label uses comprise-

• Pancreatic cancer
• Gastric cancer
• Esophageal cancer
• Biliary tract cancer

How does Oxaliplatin work?It binds to the DNA of the cancerous cells.It forms erroneous DNA cross-links.It blocks the multiplication and replication of DNA.It leads to programmed cell death.What are Oxaliplatin injection side effects?It is a systemic chemotherapy drug.It affects both the cancer and the healthy cells.

• Nerve damage
• Gastrointestinal side effects
• Low blood count
• General fatigue
• Temporary hair thinning

The severe side effects-

• Allergic reaction
• Signs of infection
• Uncontrolled bleeding
• Signs of heart problem

What precautions must be considered while on Oxaliplatin therapy? Oxaliplatin reduces the blood count.It impairs immunity and healing capabilities of the body.

• Avoid extreme cold temperatures
• Delay or avoid dental procedures

It is important to maintain contraception.Oxaliplatin severely harms the fetus.Conditions that need cautious monitoring:

• Kidney disorder
• Prior neuropathy
• Cardiac disorders
• Elderly patients above 65 years of age
• Low blood count

The critical warnings and precautions that require strict vigilance - Allergic reaction- Oxaliplatin can cause an anaphylactic reaction in many individuals.It must be immediately stopped or permanently discontinued.Pregnancy /breastfeeding – It can harm the fetus. Avoid its use in pregnant or lactating women.Neurological toxicity- Oxaliplatin can cause immediate nerve spasms or long-term nerve damage.Severe Myelosuppression – The chemotherapy drugs severely lower the blood count.The risk of infection and bleeding must be mitigated.Severe renal impairment – In kidney dysfunction, the kidneys are unable to filter platinum-based drugs.It can lead to severe toxicity.Pulmonary toxicity – Though it is rare, it can cause permanent lung scarring.Cardiovascular toxicity- It can cause QT prolongation and cardiogenic shock.Rhabdomyolysis- In rare conditions, it can cause rapid breakdown of the muscle tissue.What are the drug contraindications with Oxaliplatin?Never use aluminum needles or IV sets; this causes precipitation of the drug.The combination of medicines that must be avoided –

• QT-prolonging medicines
• Nephrotoxic drugs
• Live vaccines

How to administer Oxaliplatin injection?It is a cytotoxic drug; it must be administered under medical supervision only.It is administered as an IV infusion only.It must be diluted with 5 % dextrose only.Never mix it with chloride salts or other alkaline drugs.Avoid diluting the solution in aluminum bags.The remaining solution must be discarded after single use.How to store Oxaliplatin injection?The unopened vial must be kept at normal temperature.Avoid freezing and exposure to light.It is a cytotoxic drug; it must be disposed properly as per the regulatory standards.