Paclitaxel Injection

Paclitaxel Injection

Classification – Anticancer injection

What is the Paclitaxel Injection?

It is an anticancer injection,
It is widely used in oncology care settings.
It is used to treat multiple types of cancers.

What Are Paclitaxel Injection Uses?

It is used against various cancers. It is used alone or in combination with other anticancer medicines for –

• • Breast cancer
• • Ovarian cancer
• • AIDS related sarcoma
• • Non-small cell lung cancer
• • Pancreatic cancer
• • Head and neck cancer

What is Paclikast- 260mg Injection?

Paclikast 260, manufactured by Aprazer Healthcare, is a Paclitaxel Injection.
It is a widely used chemotherapy injection.
It is affordable and available worldwide.
It is widely used in oncology care settings and cancer hospitals to treat breast cancer, small-cell lung cancer.
The strengths available include – Paclikast 260mg, Paclikast 300mg

Aprazer Healthcare – Leading Choice for the Anticancer Range

Aprazer Healthcare is the top oncology injectable manufacturer. We manufacture the widest range of generic anticancer medicines and injections.
Aprazer Healthcare manufactures and exports the top anticancer drugs and formulations to countries worldwide.
Leveraging advanced technology, we are focused on developing competitive medicines for affordable, effective treatments.

What is the Working of Paclitaxel Injection?

It inhibits the cell cycle process.
It inhibits the formation of spindle or microtubules.
It stops cell division. It causes cell death.

What Can Be the Paclitaxel Injection Side Effects?

Paclitaxel affects the normal healthy cells.

It inhibits the rapid cell division. It leads to –

Bone Marrow Suppression – It lowers the formation of blood cells.

• • Increases the risk of infections.
• • UTI
• • Anemia
• • Increases risk of bleeding
• • weakness

GIT Side-effects – It interrupts the stomach layer.

• • Indigestion
• • Mouth ulcers
• • Nausea
• • Vomiting

Nerve Damage – It causes peripheral neuropathy.

• • Muscle and joint pain
• • Numbness of limbs,
• • tingling in hands, fingers

Why Does Paclitaxel Have Serious Side Effects?

Severe effects are caused due to its effect on cell formation.
It interrupts blood formation.
Allergy – It can cause an allergic reaction.

• • Difficulty in breathing
• • Low blood pressure
• • Swelling on the face

Low Blood Formation – Low Blood Count

• • Anemia
• • serious infections
• • bleeding

Cardiovascular Effects –

• • Arrhythmia
• • Cardiac arrest
• • chest pain

Other Toxicities –

• • Liver toxicity
• • Nerve damage
• • Severe gastrointestinal toxicity
• • lung inflammation
• • Injury at the injection site

When to Use Paclitaxel Injection Carefully?

To be used cautiously in patients with –

• • Liver disorders
• • Renal disorders
• • Hypertension patients
• • Elderly patients
• • Pre-existing infections
• • Immune-compromised patients
• • Adjuvant to myelo-suppressive treatments

What to Avoid With Paclitaxel Injection?

Certain medicines alter the paclitaxel absorption.

It can lead to toxicity or lowered efficacy.

It must not be used with –

• • Other chemotherapy drugs
• • Antifungal medicines
• • Antibiotic medicines
• • Live vaccines
• • Anticonvulsants
• • Antihypertensive medicines
• • Grapefruits

When Not to Take Paclitaxel?

To be used as prescribed by the doctor.
Avoid its use in –

• • Breastfeeding mothers
• • Pregnant ladies
• • Allergy to the drug

What to Monitor With Paclitaxel Injection?

Due to severe side effects caused by paclitaxel, it should be carefully monitored and used.

Regular monitoring of –

• • Total blood count
• • Liver functions
• • Infection risks
• • Heart functions
• • Neuropathy

Where to Store Paclitaxel Injection?

An unopened vial can be stored at normal temperature.
Diluted solution stored at refrigerator temperature is stable for 28 days.
Infusion should be used immediately.
It can be stored at normal temperature, and can be used within 27 hours.
Infusion stored in the refrigerator can be used for 14 days.

How to Inject Paclitaxel Injection?

Use as a slow IV infusion only.
Do not give as an IV push/bolus.

Conclusion

Paclikast injection should be handled carefully. It is toxic.
A corticosteroid is to be administered before to prevent a reaction.