Pemetrexed Injection

Pemetrexed Injection

Classification – Anticancer Injection

What is Pemetrexed Injection?

It is an antifolate medicine. It is a widely used anticancer injection.

What Are Pemetrexed Injection Uses?

It is used to treat Lung cancers-

• • Non-small cell lung cancer
• • Aggressive lung cancer of the pleural layer.

What is Pemeaxis Injection?

Pemeaxis is a pemetrexed injection manufactured by Aprazer Healthcare. With worldwide availability, it is the top anticancer injection used in leading hospitals. Pemeaxis injection is widely used for Lung cancer.

Why Choose Aprazer Healthcare for Anticancer Injections?

Aprazer Healthcare is India’s leading oncology injectable manufacturer.

Specialized in manufacturing oncology injections, we manufacture a range of chemotherapy injections.

Our stringent quality control measures and strict adherence to regulatory standards set us apart as the top anticancer injection manufacturer.

We manufacture sterile potent injections using the latest technology.

• • RTU technology injections
• • Infusion vials
• • Single-use vials
• • Prefilled syringes
• • freeze-dried powders

Our anticancer product portfolio includes-

• • Doxorubicin injection – Dorucin 10mg
• • Dacarbazine 200mg injection – Dacarzer 200
• • Cytarabine 500 mg Injection – Cytarzer 500

What Does Pemetrexed Injection Do?

It interrupts the folic acid formation. Folic acid is used by cancer cells to build nucleic bases of DNA and RNA.

It leads to cancer cell death.

What Are the Pemetrexed Injection Side Effects?

Pemetrexed injection affects the rapidly dividing cells, causing –

• • Fatigue
• • Nausea
• • Bone marrow suppression
• • Mouth ulcers
• • Reduced appetite
• • Diarrhea
• • Fluid retention
• • Hair loss

Why Does Pemetrexed Injection Cause Severe Side Effects?

Severe Myelosuppression – It suppresses the blood cell formation.

It leads to severely low blood count.

It leads to anemia.

It reduces WBC count, increasing the risk of infections.

It depletes platelets and causes a risk of bleeding.

Renal Toxicity – It is excreted from the kidneys. It leads to injury in the nephrons.

It can be highly toxic when used with NSAIDS.

Dehydration also increases the risk of injury.

Pulmonary Toxicity – It affects the lung tissues. It causes injury in previously treated lungs by radiotherapy.

The drug accumulates in the lungs.

Skin Toxicity – It causes blistering, peeling of the skin. It causes cytotoxicity.

Anaphylactic Reaction – it leads to a reaction in cases of allergy.

• • Swelling of the face
• • Difficult breathing
• • Drop in bp

Heart Dysfunction – It damages cardiac muscles. It decreases heart pumping.

It causes inflammation. It can also cause fluid accumulation in the heart.

Why Use Pemetrexed Injection Cautiously?

Pemetrexed injection should be given with folate/B-12 supplement.

A steroid should be given before the injection. It prevents hypersentivity.

Pemetrexed injection should be used carefully in –

• • Liver disorders
• • Renal disorders
• • Blood disorders
• • Drug interactions
• • Live vaccine
• • Use contraception

What Not to Use With Pemetrexed Injection?

It should not be used in-

• • Allergy or hypersensitivity to the drug
• • Pregnant women
• • Breastfeeding women
• • Renal impairment
• • People with severely low blood counts
• • Avoid using NSAIDS and other nephrotoxic drugs

What to Monitor Using Pemetrexed Injection?

Regular monitoring is important to

• • Blood count
• • Liver functions
• • Kidney functions
• • Dehydration
• • Electrolyte balance

What is Storage Requirement for Pemetrexed Injection?

The powdered form is to be stored at room temperature.

Store the diluted form in the refrigerator (2-8 degrees Celsius).

It should be used within 24 hours. Protect from light.

How to Administer Pemetrexed Injection?

• • It can be given as an IV infusion only.
• • Use immediately after reconstitution.
• • Avoid mixing with calcium components.

What Are the Pemetrexed Drug Interactions?

Pemetrexed injection should not be given with-

NSAIDs – They reduce pemetrexed renal clearance.

It increases the risks of –

• • Gastrointestinal toxicity
• • Severe bone marrow suppression

Live Vaccines – They increase the risk of infection.

Proton Pump Inhibitors – They reduce their excretion. It leads to severe bone marrow suppression.

Aminoglycoside Antibiotics – They reduce pemetrexed excretion.

This leads to severe bone marrow depression.

Conclusion

Pemetrexed injection, used for lung cancer, must be monitored for bone marrow function.

Always use a folate supplement. Drink plenty of water.