Rabeprazole & Domperidone Capsules

Rabeprazole (EC) and Domperidone (SR)

Classification: Gastroenterology medicine

What is the Rabeprazole (EC) and Domperidone (SR) combination?

It is a targeted formulation that reaches the intestine and has a prolonged effect.

Rabiaxis D contains rabeprazole (EC) and domperidone (SR) and is manufactured by Aprazer Healthcare.

It is used worldwide to treat various gastrointestinal conditions.

Aprazer Healthcare is a pharmaceutical manufacturer.

Recognized as a gastroenterology medicine manufacturer, we manufacture a wide range of gastrointestinal drugs.

We supply a wide range of generic drugs to countries in Asia, Africa, and America.

Our GIT product portfolio spans proton pump inhibitors and acid-relieving drugs.

What are rabeprazole and domperidone drug uses?

The combination is used for gastric issues related to high acidity and motility.

• Gastroesophageal Reflux Disease
• Stomach ulcers
• Dyspepsia
• Nausea and vomiting

Mechanism of action of rabeprazole (EC) and domperidone (SR) combination -

Rabeprazole inhibits the acid pump in the stomach.

It reduces stomach acid and relieves heartburn.

The enteric coating prevents degradation of the drug in the stomach.

Domperidone increases gut motility.

It speeds up the movement of the upper digestive tract.

The sustained-release effect provides long-lasting control over nausea and vomiting.

What are the rabeprazole and domperidone side effects?

The side effects are usually well–tolerated and resolve on their own.

• Dry mouth
• Headache/dizziness
• Stomach issues
• Hormonal changes

The side effects that need medical intervention -

• Irregular heartbeat
• Severe allergy
• Persistent diarrhea
• High fever
• Severe stomach cramps

Rabeprazole and Domperidone drug interactions -

1. They must not be co-administered with drugs that prolong the QT interval.

• Specific antibiotics
• Certain antifungals
• High blood pressure medications
• Psychiatric drugs

2. Rabeprazole alters drug absorption.

It reduces the efficacy of the following drugs -

• HIV medications
• Oral antifungals
• Certain iron supplements
• Digoxin (increased absorption leading to toxic buildup)

3. Rabeprazole and Domperidone alter drug metabolism in the liver.

This can lead to toxic buildups or reduced efficacy.

• Clopidogrel
• Warfarin

4. OTC pain-killers may irritate the stomach, increasing GI side effects.

What are the warnings and precautions associated with the use of rabeprazole and domperidone?

Cardiac warnings -

Domperidone increases the electrical conductivity in the heart.

Cardiac function must be strictly monitored in elderly patients.

It is contraindicated to be used in people with pre-existing –

• Irregular heartbeats
• Severe liver diseases

Gastrointestinal warnings -

Domperidone increases gut motility. It can cause fatal complications if used in -

• Intestinal bleeding
• Bowel perforation
• Mechanical intestinal blockages

Pituitary gland tumors

Domperidone increases the release of prolactin hormone.

It must be avoided in prolactin-releasing pituitary tumors.

Reduced mental alertness -

The combination causes dizziness, drowsiness, or blurred vision.

Driving /operating heavy machinery may be risky.

Pregnancy/Breastfeeding –

Avoid its use in pregnancy.

Domperidone passes into breast milk; nursing mothers must always consult the doctor.

Long–term risk –

Using Rabeprazole for a long duration (more than 3 months) can cause –

Bone weakening/muscle spasms

The PPIs reduce the absorption of calcium and magnesium.

It also leads to vitamin B-12 deficiency.