Tenofovir Disoproxil Fumarate & Emtricitabine Tablets

Tenofovir Disoproxil Fumarate and Emtricitabine Tablets

Classification – HIV medicine

What is Tenofovir Disoproxil Fumarate/Emtricitabine Tablet?

It contains two drugs. It forms a single-dose tablet regimen.
It is used worldwide. It is an effective, potent combination.
It is used against HIV and Aids.

Tenofovir Disoproxil Fumarate/Emtricitabine Tablet Uses

• • HIV-1 treatment
• • HIV -1 pre-exposure prophylaxis.
• • HIV post-exposure prevention.
• • Hepatitis B co-infections

What are Temirazer Tablets?

It is a fixed-dose combination.
It contains two drugs.
Temirazer, manufactured by Aprazer Healthcare, is used for HIV treatment.
It is a potent combination. It is used for both hepatitis B and HIV infections.

Aprazer Healthcare – Pioneering Advanced HIV Care Medicines

Manufacturing the latest therapy drugs, Aprazer Healthcare ranks as India’s top HIV medicine manufacturer.
We manufacture a range of antiviral drugs, including –

• • Top quality HIV medicines
• • Best quality Hepatitis B medicines
• • Top affordable Hepatitis C medicines

With global availability and presence, we are recognized as the top HIV medicine exporters to South Africa.

Our Product Range for HIV Medicine Includes

• • Tenofovir Disoproxil Fumarate, Emtricitabine tablets- Temirazer
• • Lamivudine tablets – Lamipure
• • Lopinavir and ritonavir tablets- Lopikast

What Does Tenofovir Disoproxil Fumarate, Emtricitabine Do?

The two drugs provide synergistic effects.
It mimics the DNA bases and terminates the DNA chain.
It inhibits cell multiplication and division.
It causes cell death.

Tenofovir Disoproxil Fumarate, Emtricitabine Benefits

• • It offers double effects.
• • It is convenient to use.
• • Significantly lowers viral load.
• • Improves immunity
• • Inhibit transmission
• • Reduce the chances of developing resistance
• • It can be used for hepatitis B.

Tenofovir Disoproxil Fumarate/ Emtricitabine Adverse Effects

It causes mild side effects.
The side effects fade away with time.

• • Nausea
• • Weakness
• • GIT upset
• • Skin rashes
• • Lightheadedness

Tenofovir Disoproxil Fumarate, Emtricitabine, Severe Side Effects

Long-term use affects the kidneys.
It is excreted through the kidneys.
Kidney Dysfunction – Excessive use of the drug accumulates in the kidney. It affects the nephron.

• • It impairs renal absorption.
• • It enhances the loss of minerals.
• • It reduces bone density.
• • Fluid retention

Mitochondrial Dysfunction

It inhibits enzymes, which lead to –

• • Lactic acid buildup
• • Liver Toxicity

Immune System-induced Inflammation – The improved immune system causes the body to respond to HIV.
Severe Allergy – It can lead to shortness of breath.
Swelling of the face, tongue.
Skin rashes.

Use Tenofovir Disoproxil Fumarate, Emtricitabine Tablets Cautiously In

• • Liver diseases
• • Kidney impairment
• • Co-infections Hepatitis B
• • Pregnant and lactating women

Do not abruptly stop the treatment.
It can cause Hepatitis B reactivation.

Warnings for Tenofovir Disoproxil Fumarate, Emtricitabine Tablet Usage

To be used under medical prescription.
Do not discontinue abruptly in Hepatitis B patients – may cause serious liver flare-ups.
Do not use in –

• • Severe liver dysfunction.
• • Severe kidney diseases
• • Allergy to the drug

Important Monitoring Considerations

Long-term use of the tablets should be monitored for –

• • Lactic acidosis
• • Liver function – elevated liver enzymes
• • Kidney functions
• • Viral loads (HIV, HBV)
• • Bone health

Interactions With Other Drugs

Do not combine with other emicitrabine or other similar drugs.
Avoid – Anticonvulsant

• • Statins
• • Antifungals
• • Anti-tubercular
• • NSAIDs and other nephrology drugs

Conclusion

It leads to effective viral suppression.
Long-term use should be checked for side effects.
It should be used and left after the doctor’s advice.