Tofacitinib Tablets

Tofacitinib Tablets

Classification: Rheumatology medicine

What Are Tofacitinib Tablets?

It is a DMARD drug. It suppresses the immune system.

It is used to reduce inflammation in rheumatology disorders.

What Are the Tofacitinib Tablet Uses?

It is used in autoimmune disorders.

Autoimmune diseases start with an overactive immune system.

Tofacitinib reduces the inflammation in –

• • Arthritis of the bones
• • Skin sores in psoriatic arthritis
• • Inflammation in the colon (Ulcerative colitis)
• • Inflammation in Spondylitis

Why Tofamark Tablets?

Tofamark, manufactured by Aprazer Healthcare, is the tofacitinib 5mg.

Tofamark is a targeted therapy DMARD, used to treat rheumatoid arthritis.

Aprazer Healthcare – The Leading Rheumatology Medicine Manufacturer

As the top company manufacturing the widest range of rheumatology medicines, Aprazer Healthcare is India’s largest rheumatology medicine manufacturer.

We are the leading rheumatology drug exporter to Africa, South America, and Southeast Asia.

Our rheumatology product catalogue includes –

• • Targeted DMARDS
• • Immunosuppressants
• • Janus kinase (JAK) inhibitors

Manufacturing a range of targeted DMARDS, we are the top tofacitinib tablet manufacturers and exporters.

What is the Working of Tofacitinib?

• • It interrupts the signaling pathway of inflammatory kinases.
• • It reduces the inflammation in the body.
• • It reduces the immune activity.
• • It stops the process of immune cells attacking the body.

What Are the Tofacitinib Tablet Side Effects?

It reduces the immune activity of the body.

It leads people to easily catch infections.

• • Respiratory infections
• • Headache
• • Nausea
• • Vomiting

It alters lipid profile – elevate cholesterol levels.

What Are the Tofacitinib Serious Side Effects?

Severe Infections – It lowers the immunity. It significantly increases the risk of infections like –

• • Tuberculosis
• • Shingles
• • Fungal infections
• • Viral infections
• • Bacterial infections

Cardiovascular Risk – It changes the lipid formation and increases clot formation in the blood.

It increases the risk of thrombosis.

It also increases the risk of heart attack, stroke in elderly people with existing cardiac conditions.

Perforations in the GIT Tract – It causes perforations in the stomach, intestine in people having ulcers or the elderly with GIT disorders.

It interrupts the inflammatory signals. It causes wear and tear in the gut lining.

It inhibits the repair system of the mucosal layer.

It also interrupts the GIT wall when used with NSAIDS or corticosteroids.

Increases Risk of Cancer – It increases the risk of cancer due to lowered immunity.

It also increases the risk of immune-related disorders.

Low Blood Count – Tofacitinib interferes with the pathway of blood cell formation.

It reduces the blood count.

It can lead to anemia due to low RBC. It reduces platelet count.

What Should We Assess Before Starting Tofacitinib Tablets?

It should be carefully assessed for infections.

Complete liver tests and blood tests should be accessed.

To be used carefully in people with medical conditions like –

• • Cancer
• • Heart disorders
• • Liver disorders
• • Kidney disorders
• • Diabetes
• • Stomach ulcers

When Not to Use Tofacitinib Tablets? (Warnings)

• • It should be used under prescription only.
• • It should not be used in an allergy to the drug.
• • Live vaccines should be avoided due to low immunity.
• • Avoid its use in people with –
• • Pregnancy
• • Serious infections
• • Severe liver disorders
• • Bleeding disorders
• • Breastfeeding
• • Smoking

What Not to Take With Tofacitinib?

Tofacitinib should not be combined with –

• • Other Immunosuppressants and DMARDS – They reduce the immunity. It increases the risk of infections.
• • Antifungal Drugs – Tofacitinib increases the drug concentration. It increases the risk of toxicity.
• • Anticonvulsant – It reduces their absorption. It declines the effectiveness.
• • NSAIDS and Corticosteroids – Tofacitinib increases the risk of perforations in GIT tract.
• • Statins – They can cause tofacitinib toxicity.
• • Grapefruits – These can cause stomach pain. It increases tofacitinib concentration.
• • Alcohol – It can cause dizziness. It can cause liver damage.

What Should Be Monitored With Tofacitinib Therapy?

Long-term tofacitinib use should be monitored for –

• • Symptoms of infections
• • Blood clots
• • Gastrointestinal issues
• • Blood count
• • Liver functions
• • Lipid profile
• • Cardiovascular functions

Conclusion

Tofacitinib is used for rheumatoid arthritis.

It is widely used in failed cases with other DMARD drugs.