Anti-Malarials Combinations
| S.No. | Dosage Form | Composition | Domestic Market | Export Market | Action |
|---|---|---|---|---|---|
| 292 | Tablets | Artemether + Lumefantrine 20 + 120 / 40 +240 / 80 + 480 mg | Yes | Yes | |
| 293 | Tablets | Hydroxychloroquine Sulphate 200/300/400 mg | Yes | Yes | |
| 294 | Tablets | Mefloquine 250 mg | Yes | Yes | |
| 295 | Tablets | Quinine 300 mg | Yes | Yes |
Anti-Malarial Combinations
Anti-Malarial Combinations
These are used for the treatment of malaria
Malaria is caused by a parasite.
Parasite is carried by the mosquito.
It enters the bloodstream.
It reaches the liver. It invades the liver cells.
They multiply and mature in the liver cell.
They then invade the red blood cells.
They reduce RBC count.
What Are the Symptoms of Malaria?
The parasite in the body causes an immune response in the body.
The high parasitic load causes -
- • Fever
- • Chills
- • Headache
- • Body ache
- • Nausea
- • Vomiting
The Severe Symptoms of Malaria Include
- • Reduced RBC count – severe anemia
- • Difficult breathing - It is caused due fluid accumulation in the lungs.
- • Confusion
- • Coma
- • Organ failure
- • Liver dysfunction
What Are the Antimalarial Combinations?
Artemisinin Combinations
Artemether + Lumefantrine-
It is used to treat uncomplicated malaria.
It is used in the early stages of malaria.
It has a fast onset of action.
Quinolone Derivatives
These are used to treat severe malaria infection.
- • Mefloquine
- • Hydroxychloroquine Sulphate
- • Quinine
Anti-folate Drugs
They are widely used for prophylaxis treatment or the advanced stages.
They are used when combined with other drugs.
- • Sulfadoxine-Pyrimethamine
- • Proguanil
What is the Working of Anti-malarial Drugs?
- 1. They inhibit hemoglobin digestion by the parasite. Parasites neutralize hematin. Drugs like quinolone cause the toxic buildup of hematin. It kills the parasite.
- 2. The anti-folate drugs – These block the folic acid synthesis in the parasite.
- 3. Drugs like Atovaquone – They damage the mitochondria.
- 4. Primaquine – It targets the malaria larvae in the liver cells.
- 5. Artemisinin drugs generate free radicals to kill malaria cells.
Why Are Antimalarial Combinations Used?
The antimalarial combinations offer –
- • Synergistic Effect - combining two others offers potent suppression of the parasite
- • Reduced Drug Resistance - The parasites are unable to develop resistance to two drugs at the same time.
- • Offer Rapid Onset of Action - The combination offers a faster action in eliminating parasites from the body.
- • Reduce the Spread of Malaria - It reduces the parasitic count. The parasites cannot be transferred.
What Are the Antimalarial Drug Side Effects?
It causes common gastrointestinal side effects and headaches, etc.
- • Nausea
- • Vomiting
- • Abdominal pain
- • Diarrhea
- • Joint pain
- • Weakness
- • Headache
- • Dizziness
Why Choose Aprazer Healthcare for Antimalarial Combinations?
Aprazer Healthcare is the top-ranking Indian pharmaceutical manufacturing company.
We manufacture a global range of antimalarial combinations.
We are the top antimalarial drug exporter across the world.
With a legacy in manufacturing the highest standard drugs, Aprazer Healthcare is one of the leading drug manufacturers from India, exporting worldwide.
With global footprints, we are recognized in the top pharmaceutical markets.
We manufacture affordable drugs with uncompromised quality.
FAQ
Are Antimalarial Drugs Used in Pregnancy?
Which is an Antimalarial Drug Used in Arthritis?
Is Malaria Communicable?
• It gets transmitted through blood bloodstream.
Can Malaria Spread From Mother to Child?
Which is the Antimalarial Combination Drug Used Widely?
• It has a fast onset of action.
• It treats the early infections.
Can Antimalarial Drugs Cause Severe Side Effects?
• Allergic reaction.
• Hemolytic anemia.
• Liver dysfunction.
Can Antimalarial Drugs Cause Hearing / Vision Loss?
• It is caused due to over term use.
