Anticoagulants & Antifibrinolytic

Anticoagulants & Antifibrinolytic

These drugs are used in blood disorders.

Anticoagulants inhibit clot formation.

Antifibrinolytic agents prevent excessive bleeding.

Clot Formation and the Anticoagulant Drugs

The formation of clots interrupts the blood flow.

It reduces the blood flow to the brain.

It reduces blood flow to heart and lungs.

Anticoagulants prevent the formation of clot.

These are widely used to prevent heart disorders.

Uses of Anticoagulant Drugs

It prevent the formation of clot. The clot interrupts the blood circulation.

The clots leads to several heart complications.

The anticoagulants are widely used in:

• • Deep Vein Thrombosis
• • Pulmonary Embolism
• • Atrial Fibrillation
• • Heart Attacks
• • Heart Valve Replacement
• • Post-Surgery Prophylaxis
• • Ischemic Attacks

Types of Anticoagulants and Their Working

Anticoagulants work by different mechanisms-

The anticoagulants inhibit the clotting factor.

It prevents the formation of clots.

Vitamin K Antagonists- Vitamin K helps formation of specific clotting factors. It blocks vitamin K. It reduces the formations clotting factors.

Example – Warfarin

Heparins- It is widely used in acute situations. It enhances the activity of the natural anticoagulant. It enhance anti-thrombin factor. It inactivates the clotting factors. It is usually given by the intravenous route.

Direct Oral Anticoagulants

Thrombin Inhibitors- It inactivates thrombin factor. It inhibits conversion of fibrinogen to fibrin.

Example – Dabigatran capsules

Xa Factor inhibitors- It inhibits the Xa factor. It is involved in clot formation.

Example -

• • Apixaban tablets
• • Rivaroxaban tablets

What Are Antifibrinolytic Drugs?

Antifibrinolytic drugs promote blood clotting.

It prevents the breakdown of clot.

It is used to prevent excessive bleeding.

The excessive bleeding lead to several complications.

• • It cause loss of blood
• • It can lead to hypovolemic shock
• • Organ failure
• • internal bleeding
• • Obstetric complications

Mechanism of Action of Antifibrinolytic Drugs

It inhibits plasmin enzyme.

Plasmin breaks down fibrin mesh.

It stops the breakdown of mesh

It enhances clot formation.

Uses of Antifibrinolytic Drugs

It is widely used to prevent bleeding after surgery.

It enhance the formation of clot.

It is used in-

• • Surgical procedures to reduce bleeding
• • Inherited coagulation disorders
• • To control heavy bleeding
• • Trauma care to prevent loss of blood
• • Nosebleeds

Drugs Used in Excessive Bleeding and Pain During Periods

Tranexamic Acid, Ethamsylate tablets

Tranexamic Acid, Mefenamic Acid tablets

Aprazer Healthcare - The Leading Pharmaceutical Manufacturer

Aprazer Healthcare manufactures a top range of anticoagulant and antifibrinolytic drugs.

We are focused on advanced care treatments.

We manufacture the affordable treatment medicines for various bleeding diseases.

We are the leading anticoagulant drug manufacturers.

Our anticoagulant product portfolio consists of –

• • Apixaban tablets
• • Dabigatran capsules
• • Rivaroxaban tablets

As the top Indian manufacturer, we are the top antifibrinolytic drugs manufacturers and exporters.

Our antifibrinolytic product portfolio consists of –

• • Tranexamic acid
• • Tranexamic acid, ethamsylate
• • Tranexamic Acid and mefenamic acid

Conclusion

Anticoagulants and antifribrinolytic are opposite drugs.

Both are used to treat bleeding disorders.

Excessive or over use can cause several side-effects.