Antilipemic Agents Combination & HMG-CoA Reductase Inhibitors (Statins)
| S.No. | Dosage Form | Composition | Domestic Market | Export Market | Action |
|---|---|---|---|---|---|
| 309 | Tablets | Fenofibrate 145/160/200 mg | Yes | Yes | |
| 310 | Tablets | Pitavastatin 1/2/4 mg | Yes | Yes | |
| 311 | Tablets | Pitavastatin 2mg + Fenofibrate 67.5mg | Yes | Yes | |
| 312 | Tablets | Pitavastatin 2/4mg + Ezetimibe 10mg | Yes | Yes | |
| 313 | Tablets | Simvastatin 10/20/40mg | Yes | Yes |
Antilipemic Agents Combination & HMG-CoA Reductase Inhibitors (Statins)
These are the combinations in which statins are combined with other drugs.
The other antilipemic drugs are added to effectively lower cholesterol.
They lower triglyceride levels.
They prevent cardiovascular diseases.
What Are Statins?
They inhibit the formation of cholesterol.
It causes the liver to develop LDL receptors.
It increases the breakdown of bad cholesterol.
- • Pitavastatin
- • Simvastatin
- • Atorvastatin
- • Rosuvastatin
The Antilipemic Agents Combination & HMG-CoA Reductase Inhibitors (Statins) Drugs
The statin drugs are combined with -
Cholesterol Absorption Inhibitors
They provide additional effect in lowering cholesterol levels.
Pitavastatin / Ezetimibe
Fibrates
These primarily lower the high triglyceride levels.
They alter cholesterol metabolism.
It increases good cholesterol levels.
Pitavastatin /Fenofibrate
Calcium Channel Blockers
They are added with a blood pressure-lowering agent.
Amlodipine /Atorvastatin
Antilipemic Agents Combination & HMG-CoA Reductase Inhibitors (Statins) Are Used for
- • They lower cholesterol and triglyceride levels.
- • They lower the buildup of plaque or fat in the arteries.
- • They reduce the formation of a clot.
- • They improve the blood vessel functioning.
- • They reduce the inflammation.
Cardiovascular Disease Prevention - These are widely used to prevent heart attacks, strokes.
- • They are effective in managing the cardiac risk factors in other diseases, like-
- • Diabetes
- • Dyslipidemia
- • Pancreatitis caused due to high cholesterol levels
Why Are Antilipemic Agents Combination & HMG-CoA Reductase Inhibitors (Statins) Better?
The combination drugs are used to effectively lower bad cholesterol levels-
- • They have greater efficacy – The two drugs offer a more potent effect.
- • They lower the bad cholesterol.
- • They increase the good cholesterol.
- • They are widely used to manage extremely high lipid concentrations.
Multiple Mechanisms of Action
The two drugs offer different ways of lowering cholesterol.
One drug inhibits cholesterol formation. The other lowers the cholesterol absorption.
Less Toxic Effects
The two drugs are combined in lower doses. The higher dose of a single drug causes toxicity.
Multiple Targeted Action
The different drugs lower the bad cholesterol.
They increase the HDL levels.
They have cardio-protective action.
They lower triglycerides.
Antilipemic Agents Combination & HMG-CoA Reductase Inhibitor Side-Effects
- • They cause gastrointestinal side effects and muscle aches.
- • It leads to the breakdown of muscles.
- • Liver dysfunction
- • Kidney dysfunction
- • Increase the blood glucose levels
- • Indigestion
- • Abdominal pain
- • Constipation
- • Bloating
- • Gas
- • Joint pain
- • Reduces absorption of vitamins
Antilipemic Agents Combination & HMG-CoA Reductase Inhibitor Drugs
- • Fenofibrate
- • Pitavastatin
- • Pitavastatin + Fenofibrate
- • Pitavastatin + Ezetimibe
- • Simvastatin
Aprazer Healthcare - The Leader in Pharmaceutical Drug Manufacturing
Aprazer Healthcare is the top Indian pharma company.
We manufacture a range of life-saving drugs.
We are known worldwide for quality drug manufacturing.
We are the top pharmaceutical drug exporters from India.
Our range of products includes-
- • Oncology orals
- • Oncology injectable
- • HIV medicines
- • Hepatitis medicine
Our cardiovascular drug portfolio includes –
- • Antihypertensive combinations
- • Antilipemic Agents Combination & HMG-CoA Reductase Inhibitors
- • Anticoagulants and antifibrinolytics
- • Lipid-lowering agents
We are the top manufacturers and exporters of cardiovascular drugs.
FAQ
Which Are the Widely Used Cholesterol-lowering Medicines?
• Pitavastatin
• Pitavastatin + Fenofibrate
• Pitavastatin + Ezetimibe
• Simvastatin
Can Cholesterol-lowering (Statin) Drugs Cause Addiction?
• It does have withdrawal effects.
What is the Long–term Side Effect of Cholesterol-lowering Drugs?
• Muscle ache and joint pain
• Lower the absorption of essential vitamins
Statins Lower the Risk of Heart Complications. How?
• It reduces plaque deposition.
• It reduces clot formation.
Can One Use Cholesterol–lowering Medicines in Pregnancy?
Cholesterol–lowering Medicines Cause Diabetes. How?
• Use carefully in high-risk people.
Cholesterol–lowering Drugs Are to Be Used Lifelong?
• It is usually a lifelong treatment.
• It lowers cholesterol levels.
• It reduces cardiovascular risk.
