Hormonal Therapy (Non-Steroidal Antiestrogen)

Hormonal Therapy (Non-Steroidal Antiestrogen)

These drugs lack a steroid molecule. These block the effects of estrogen in the body.

These are widely used to treat estrogen-dependent cancers.

It is widely used to treat breast cancer.

These have partial agonist activity. It mimics estrogen action in bones.

Hormonal Therapy (Non-Steroidal Antiestrogen) Uses

Osteoporosis - Bone loss occurs after menopause. It reduces the degradation of mineral density.

It reduces the risk of fractures in old age.

It is used to prevent bone loss.

Hormone-dependent Breast Cancer -

It inhibits estrogen secretion.

It stops the growth of breast tumors, dependent on estrogen.

It is widely used as adjuvant therapy. It reduces the risk of recurrence.

It is used to shrink the tumor before surgery.

Gynecomastia -

It is used to treat enlarged breast tissue in men.

To Treat Infertility -

It is used to treat infertility in men and women.

It increases testosterone levels in males.

It induces ovulation in women.

Working of Hormonal Therapy (Non-Steroidal Antiestrogen)

These are the selective estrogen blockers.

They bind to the receptors in the targeted cells.

They modulate the shape and structure. It antagonizes the receptors in breast tissue.

They mimic the estrogen effects in other tissues.

They do not cause bone loss.

They protect the heart cells.

Hormone Therapy (Non-steroidal Antiestrogen) Causes Side Effects. Why?

The side effects are caused by changes in hormone levels.

• • Hot flushes
• • Nausea
• • Fatigue
• • Headache
• • Joint pain

Some severe side effects include-

• • It increases clot formation.
• • It induces liver toxicity.
• • Increases risk of endometrial cancer.

What Are the Benefits of Non-steroidal Antiestrogen?

They are selective in nature.

It inhibits estrogen receptors in targeted cells.

It reduces the risk of recurrence.

It does not cause bone loss.

It helps maintain bone mineral density.

The Medicines Widely Used for Hormone-positive Breast Cancer

SERM Drugs - They selectively target the estrogen hormone receptors in the breast.

They have estrogen agonist effects in other tissues.

They do not cause bone loss.

Tamoxifen - It is widely used to treat breast cancer. It can be used in both young and elderly women.

Non-steroidal Aromatase Inhibitors - They reduce the estrogen hormone formation.

Anastrozole (Anzakast, manufactured by Aprazer Healthcare) - It is used in early-stage breast cancer or the advanced stage.

It is widely used after the cessation of periods.

Letrozole (Letrakast, manufactured by Aprazer Healthcare) - It is widely used to treat advanced breast cancer.

It is used to treat resistant breast cancer. It is used in failed anti-estrogen therapy.

SERD - These are the drugs that block the estrogen receptor.

They degrade the estrogen receptors.

Fulvestrant Injection - Fulveskast injection is the prefilled syringes.

It is a fulvestrant injection, manufactured by Aprazer Healthcare.

Aprazer is the leading oncology injectable manufacturer.

We manufacture a range of chemotherapy injections.

• • Carbokast 150mg - Carboplatin Injection IP
• • Daunozer 20mg - Daunorubicin Injection IP 20mg

Aprazer Healthcare – Top Pharmaceutical Company from India

Aprazer Healthcare is the leading pharmaceutical manufacturer from India.

We manufacture a diverse range of products.

It includes Oncology, Hepatology, and Nephrology care medicines.

Recognized as the leading pharma manufacturer, we are top oncology drug manufacturers in India.

With the largest oral manufacturing plant in India, Aprazer Healthcare manufactures a comprehensive range of anticancer medicines.

We manufacture the global-quality, advanced oncology orals and oncology injections.

Trusted across the globe, Aprazer Healthcare is the largest oncology oral exporter worldwide.

Conclusion

Leading the Indian pharmaceutical market for oncology medicines, Aprazer Healthcare has the extensive infrastructure to manufacture the top-quality, affordable range of –

• • Anticancer Medicines
• • Anticancer Injections