Proton Pump Inhibitor IBS & Gastro Resistant
| S.No. | Dosage Form | Composition | Domestic Market | Export Market | Action |
|---|---|---|---|---|---|
| 296 | Tablets | Acotiamide 100 mg | Yes | Yes | |
| 297 | Capsules | Dexlansoprazole Modified Release 30/60 mg | Yes | Yes | |
| 298 | Capsules | Dexrabeprazole 10 mg + Domperidone 30 mg Sustained Release | Yes | Yes | |
| 299 | Capsules | Esomeprazole 20/40 mg + Domperidone 30 mg | Yes | Yes | |
| 300 | Capsules | Esomeprazole 40 mg + Levosulpiride 75 mg | Yes | Yes | |
| 301 | Capsules | Lansoprazole 30/60 mg | Yes | Yes | |
| 302 | Capsules | Pantoprazole 40 mg + Cinitapride 3 mg Sustained Release | Yes | Yes | |
| 303 | Capsules | Pantoprazole 40 mg + Domperidone 30 mg Sustained Release | Yes | Yes | |
| 304 | Capsules | Pantoprazole 40 mg + Itopride 150 mg | Yes | Yes | |
| 305 | Capsules | Rabeprazole 20/40 mg + Domperidone 30 mg Sustained Release | Yes | Yes | |
| 306 | Capsules | Rabeprazole 20 mg + Itopride 150 mg | Yes | Yes | |
| 307 | Capsules | Rabeprazole 20 mg + Levosulpiride 75 mg Sustained Release | Yes | Yes | |
| 308 | Tablets | Trimebutine Maleate 100/200/300/400 mg | No | Yes |
Proton Pump Inhibitor IBS & Gastro Resistant
They reduce excess stomach acid.
It is widely used for symptomatic relief of many gastrointestinal problems.
These are used in gastric reflux disorder and ulcers.
They relieve symptoms of acidity, indigestion.
Uses of Proton Pump Inhibitor, IBS & Gastro-resistant Drugs
These drugs are widely used to relieve-
- • Heartburn
- • Acidity
- • Indigestion
Why Are Proton Pump Inhibitor Ibs & Gastro-resistant Drugs Used in Gastrointestinal Disorders?
• GERD / Esophagitis
In this, the stomach acid flows back to the throat.
It irritates the food pipe. This leads to esophagitis.
It causes heartburn.
PPI inhibits the formation of acid.
• Peptic Ulcer
The excess acid erodes the internal lining.
It causes the formation of ulcers.
The reduced formation of acid.
It aids in healing or reduces irritation.
• Zollinger-Ellison Syndrome
It is a hyperacid secretion.
PPIs are used to inhibit the secretion of acid.
• H. pylori infection
They produce a synergistic effect. They increase the stomach PH. The bacteria cannot survive.
How are PPIs Gastro-resistant Drugs?
The PPI capsules and tablets are coated with an enteric layer.
They have targeted action.
They bypass the stomach and are absorbed in the intestine.
They do not break down in stomach acid.
Proton Pump Inhibitor Ibs & Gastro-resistant Drugs Control Acid Formation. How?
It works as an acid inhibitor.
It blocks the proton pump. The pump aids acid secretion.
It irreversibly binds to the pump and blocks its effect.
The proton pump inhibitors are enteric-coated.
It protects them from degradation in acid.
Proton Pump Inhibitor Drug Side Effects
For short-term use, it causes mild side effects:
- • Headache
- • Diarrhea
- • Nausea
- • Abdominal pain
- • Gas
- • Constipation
- • Dry mouth
- • Skin rashes
The long-term use causes severe side effects:
It leads to deficiencies.
It inhibits the absorption of micronutrients like –
- • Magnesium
- • Zinc
- • Calcium
- • Iron
It increases the risk of bone loss.
It increases the risk of bone fractures.
It reduces the acid to kill harmful bacteria. It increases the risk of infection.
It disrupts the GIT flora. It reduces the healthy bacteria in the stomach.
Important Drug Interactions With Proton Pump Inhibitors
Proton pump inhibitors change the gastric PH.
It reduces the absorption of various drugs.
It lowers their efficacy.
- • Antifungal drugs
- • Anticoagulant drugs
- • Anticancer drugs
- • Anticonvulsant drugs
Proton Pump Inhibitor IBS & Gastro Resistant Drugs
- • Esomeprazole + Domperidone capsules – Eprakast DSR
- • Esomeprazole 40mg – Eprakast 40
- • Esomeprazole + Levosulpiride
- • Lansoprazole
- • Pantoprazole + Domperidone
Aprazer Healthcare – The Leading Pharmaceutical Company (India)
Aprazer Healthcare is recognized as the top leaders in the pharmaceutical landscape.
We manufacture standard quality drugs. We are the leading drug exporters across the world.
Ranging from gastrointestinal care to the oncology range, Aprazer manufactures an exclusive range of pharmaceutical medicines.
Ranked as the top gastroenterology medicine manufacturer from India, we manufacture the highest quality gastrointestinal products.
Our gastroenterology product portfolio includes:
- • Proton pump inhibitors - Eprakast DSR
- • Gastro-selective antibiotics – Rifaxigem 400
- • Hepatoprotective agent – Udikast 300
Conclusion
The proton pump inhibitors are available over the counter.
They are highly effective for short-term use.
The long-term use of the drugs is to be under a doctor's advice.
FAQ
What is the Role of PPI in IBS?
• These are used in IBS to relieve acidity or the underlying symptoms of gas and bloating.
• These do not cure IBS.
How to Take Proton Pump Inhibitor Drugs?
• They are taken 2 hours before or after food.
• Food impairs their absorption.
Are the PPI and Antacids the Same?
• Antacids have a short duration of action. They neutralize acid.
• Proton pump inhibitors have long-term effects. They block the secretion of acid.
What is the Long-term PPI Side-effect?
• It reduces the acid. Acid is essential to kill bacteria.
• It led to the growth of bacteria.
What Alcohol Causes With Proton Pump Inhibitor Drugs?
• It irritates the stomach lining.
• It must be avoided.
