ACALAKAST 100mg

Composition:

Each capsule contains Acalabrutinib – 100 mg

Therapeutic Class:

Antineoplastic

What is Acalakast?

Acalakast is a new-generation Bruton’s Tyrosine Kinase (BTK) inhibitor, used in targeted therapy against white blood cancers, specifically B-cell malignancies.

Uses of Acalakast:

• • Chronic Lymphocytic Leukemia
• • Lymphocytic Lymphoma
• • Mantle Cell Lymphoma

How does Acalakast work?

In B-cell cancers, abnormal B-cells grow and spread uncontrollably. Acalabrutinib blocks the kinase enzyme (BTK), which disrupts the signaling pathway responsible for B-cell division and growth.

Common Side Effects:

Headache, nausea, vomiting, constipation, diarrhea, joint pain, abdominal pain, and fatigue.

Serious Side Effects:

Fever, sore throat, blood in stool, infections, and fast/irregular heartbeat.

Warning:

Not to be used in patients with known hypersensitivity to Acalabrutinib or any of its excipients.

Precautions:

Use with caution in:

• • Renal insufficient patients
• • Breastfeeding mothers
• • Pregnant women

Toxicities:

Common toxicities include:

• • Neutropenia – Increased risk of infections
• • Thrombocytopenia – Risk of bleeding
• • Anemia – Decreased red blood cell count

Other toxicities: Atrial fibrillation, bleeding, hypertension, skin infections

Indications for Use:

Acalakast is a prescription medication to be used under medical supervision only.

While generally well tolerated, it requires regular monitoring for blood counts, infections, bleeding risks, and cardiac toxicities.