Ledikast

Ledikast

Composition: Ledipasvir & Sofosbuvir

Therapeutic Class: Direct-Acting Antivirals

Ledikast: Trusted Hepatitis C Medicine with Synergistic Power

Aprazer’s Ledikast is the widely prescribed and well-tolerated, scientifically backed formula against Hepatitis C infections.
Ledivakast, exported to 20+ countries, is widely accepted and preferred for consistent quality and efficacy.

Aprazer: Advancing Global Access to Hepatitis C Medicines

As the leading Hepatitis C medicine manufacturer and exporter, Aprazer develops affordable and high-quality hepatitis C medicines.
WHO-GMP certified, assured therapeutic efficacy and safety.

What is Ledikast?

Ledikast is a combination of two potent antivirals, used in Chronic Hepatitis C infections.

Uses of Ledikast

• • Used treatment for Hepatitis C in new patients
• • Used previously failed treatments
• • HIV-HCV co-infections

How does it work?

• • Ledipasivir – inhibit NS5A protein
• • Sofosbuvir – inhibits the NS5B polymerase enzyme
• • The combination offers a synergistic effect, inhibiting viral RNA replication and assembly.

Benefits

• • Can be used in compensated cirrhosis
• • HIV co-infections
• • In pediatric patients above 12 years of age
• • After liver transplants
• • Potent viral load suppression
• • Improves liver functions

Common Side Effects

• • Nausea
• • Dizziness
• • Headache
• • Digestive issues
• • Tiredness
• • Diarrhea

Serious Side Effects

• • Severe Bradycardia (when taken with amiodarone)
• • Hepatitis B flare-ups occur in previous hepatitis B infections.
• • Severe liver failure in an advanced stage of liver disorder
• • Severe drop in red blood count when combined with ribavirin
• • Changes in urination, swelling, and fatigue
• • Confusion, depression

Precautions

To be used cautiously in patients:

• • End-stage kidney disorder
• • Severe cirrhosis
• • HIV co-infections
• • Cardiac disorders
• • Drug interactions- amiodarone, ribavirin
• • Blood disorders

Contraindications

• • Not to be used if any previous allergy or hypersensitivity to Ledipasvir, sofosbuvir, or any excipients
• • Breastfeeding mothers
• • Pregnant women

Warning

• • It is a prescription drug to be taken under medical supervision only

Important Safety and Monitoring Information

Regular monitoring of hepatic functions, renal functions, cardiac functions, co-infections, blood count and neuropsychiatric adverse reactions.

Drug interactions – Ribavirin and Amiodarone