Tacrolimus (Xgraf) Remains a Cornerstone of Modern Transplant Medicines
Tacrolimus (Xgraf) is a strong immunosuppressant.
It is prescribed worldwide, preventing acute graft rejection.
Improving long-term outcomes, it is the mainstay immunosuppressive treatment drug used in post-kidney transplantation management.
- Reduces the risk of acute rejection by 30- 40 percent.
- Lowers the risk of graft loss by 44 percent (six months of use).
Xgraf (tacrolimus), manufactured by Aprazer Healthcare, is a highly affordable, globally available tacrolimus brand.
Tacrolimus tablets manufactured by Aprazer Healthcare are available in 3 strengths-
As a leading nephrology medicine manufacturer, Aprazer Healthcare manufactures a diverse range of immunosuppressants widely used in kidney transplantation.
Manufacturing precision-dose drugs with uncompromised quality, Aprazer Healthcare is a globally trusted brand for immunosuppressants.
We are the top drug exporter for immunosuppressive agents worldwide.
What is the working of Tacrolimus (Xgraf)?
It suppresses the activation of T-cells.
It calms down the immune system.
It prevents immune activity against the foreign organ.
It has targeted action suppressing white blood cells.
Why is Tacrolimus (Xgraf) a first-line drug for transplant prevention?
Tacrolimus is a gold standard drug –
- More potent than old cyclosporine.
- Prevents acute rejection episodes.
- Offers long-term graft protection.
- Fewer cosmetic side effects
Other uses of Tacrolimus(X-Graf) –
It is widely used to treat severe autoimmune conditions.
- Rheumatoid arthritis
- Nephrotic syndromes
- Severe skin allergies
- Eczema
Why is regular blood monitoring required with Tacrolimus (X-Graf)?
Besides its wide utility, Tacrolimus has a narrow therapeutic window.
It has low safety margins.
A slight increase in dose can be life –threatening.
It may induce toxicity or lead to graft rejection.
Blood levels of the drug are measured 12 hours after the dose and immediately before the next dose.
Fluctuating drug levels can lead to –
- under- immunosuppressive effect
- over- immunosuppressive effects
What are the notable side effects of Tacrolimus (X-Graf)?
Tacrolimus significantly constricts the blood vessels
It reduces blood circulation/flow.
Renal toxicity – The use of tacrolimus can cause acute kidney injury.
The long –term use leads to reduced blood supply to the nephrons.
It leads to chronic kidney injury.
Post-transplant diabetes-
It damages the pancreatic cells, elevating sugar levels.
High blood pressure – It causes narrowing of the blood vessels and also activates the sympathetic nervous system, raising the blood pressure.
Risk of severe infections- Targeting the white blood cells, lowers the body’s immunity.
It lowers resistance against infections.
Neurotoxicity- The drug reaches the brain.
It irritates the peripheral nerves.
Leads to shaky movements/tingling sensations.
Why choose Aprazer Healthcare for immunosuppressive agents?
Aprazer Healthcare is the leading generic drug manufacturer.
- WHO-GMP-certified manufacturing
- Precision dose formulations
- Stringent quality controls
- Robust distribution network
