HIV Backbone Combinations by Aprazer Healthcare :- Tenofovir /Emtricitabine (Temirazer) and Abacavir /Lamivudine (Abakast L)
HIV treatment usually consists of a combination of 3 drugs.
The two drugs combined from the NRTI class form the foundation.
The other drug forms the basis of the treatment to make it work.
The drugs are from 2 different classes; they effectively inhibit viral cell multiplication at different stages.
These are combined to form a fixed-dose combination.
At Aprazer Healthcare, we are dedicated to manufacturing anti-retroviral combinations, dispensing the multiple drugs into a single pill.
As the leading HIV medicine manufacturer, Aprazer Healthcare manufactures a global range of HIV medicines.
We are the leading HIV drug exporter to countries worldwide.
The anti-retroviral combination forms the gold standard treatment for HIV
The anti-retroviral combination offers –
- Better control
- Lower drug resistance
- Fewer side effects
- Improve immune functions
- Stop transmission
- better compliance
- Lower pill burden
The commonly combined 2 drugs include
- Nucleotide reverse transcriptase inhibitors (NRTIs)-
These form the foundation of antiretroviral combinations.
The two drugs are combined to offer a synergistic effect.
These get incorporated into the viral cell.
It inhibits the multiplication of the virus.
- Integrase Strand Transfer Inhibitors (INSTIs)
If the virus manages to form the DNA, integrase inhibitors inhibit the final step.
It stops the virus from integrating its DNA into the human DNA.
Which are the two widely used antiretroviral combinations for HIV?
It is a widely used combination and forms the backbone of HIV treatment.
Together, they reduce the viral count to zero.
It is also used for pre-exposure HIV prophylaxis.
It can be used for both Hepatitis B and HIV.
Both drugs mimic the nucleic acid bases.
They incorporate into the viral chain and act as chain terminators.
The combination offers a high resistance barrier.
It has a longer intracellular half-life.
- Abacavir and Lamivudine (Abakast-L)-
It blocks the conversion of RNA to DNA.
They cause chain termination.
It improves immune function.
It inhibits opportunistic infections.
It prevents the transmission of HIV.
Which is better, Tenofovir or Abacavir?
Both are strong anti-retrovirals.
They both effectively manage HIV.
The choice of treatment depends upon the health profile and viral load.
Tenofovir and emtricitabine (Temirazer) are preferred in –
- High viral load
- Hepatitis B co-infections
- People with cardiovascular risk
- Emtricitabine offers high resistance barrier
Abacavir and Lamivudine (Abakast-L) are preferred in –
- People with risk of renal disorder
- osteoporosis
- It increases cholesterol levels and increases the risk of cardiac problems.
Conclusion – Tenofovir is the first-line treatment, globally preferred combination used to control high viral loads.
Abacavir is the alternative treatment drug widely used in people with renal disorders/bone dysfunctions.
Abacavir therapy requires genetic testing.
