Lopinavir and Ritonavir USP Tablets

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Classification – HIV medicine

Lopinavir/ Ritonavir?

It is the two drugs with antiviral activity. It is an approved combination to treat HIV infection.

Uses of Lopinavir /Ritonavir –

HIV-1 infection

It is used as prophylaxis against HIV exposure

What is Lopikast?

It is a fixed-dose combination made to treat HIV infection. Lopikast, trusted and accepted worldwide, is widely prescribed by the leading doctors and hospitals.

Why Aprazer Healthcare?

Aprazer Healthcare is the leading antiviral drug manufacturer. We develop an extensive range of antiviral combinations, direct-acting antivirals, and anti-retrovirals.

We manufacture global standard antiviral drugs.

Known for the best quality and highest health standards, we are the leading HIV medicine manufacturer and exporter.

Lopinavir /Ritonavir Working

It is a combination of two antivirals. Lopinavir inhibits HIV viral cell formation.

It inhibits the HIV protease enzyme.

Inhibit cell multiplication and replication.

Causes viral cell death.

Ritonavir enhances its activity and effectiveness to cause a more potent effect.

Lopinavir/Ritonavir – Benefits

Lopinavir /Ritonavir is used for its effective viral suppression.

Ritonavir prolongs antiviral activity.

- • It significantly lowers the viral load.
- • Improves immune function.
- • Increases CD-4 cell count.
- • It lowers the incidence of resistance.
- • Stops disease progression.
- • It improves liver functions
- • It is effective in children
Lopinavir/Ritonavir- Adverse Effects
It causes a number of gastrointestinal side effects,
It leads to malabsorption, and disturb metabolism.
- - • Nausea
  - • Vomiting
  - • Tiredness
  - • Increase cholesterol levels
  - • Increase blood sugar
  - • Headache
  - • Rash, itchiness
Serious Side Effects
Severe side effects are caused due to long-term use, which causes metabolic dysfunction.
It causes changes in insulin storage and fat metabolism.
It leads to increased cholesterol in the blood and insulin resistance.
Other side effects include-
- - - • Hepatotoxicity – elevated liver enzymes
    - • QT prolongation and cardiac toxicity
    - • Severe heart complications
    - • Lactic acid buildup
    - • Pancreatitis
    - • Allergic reaction
    - • Wasting of face, buffalo hump, and thinning of legs
Precautions for Lopinavir, ritonavir
To be used cautiously in people who liver complications and checked for drug combinations.
Severe liver disorders:
- - - • Renal impairment
    - • Cardiovascular diseases
    - • High cholesterol levels
    - • Pancreatitis
    - • Bleeding disorders
    - • Elderly
    - • Diabetics
    - • hypertension
    - • Children
    - • Pregnant and breastfeeding women
Important monitoring considerations
Regularly check viral load and CD4 count, it tells about drug efficacy.
For better control over side effects, always monitor-
- - - • Liver functions
    - • Kidney functions
    - • Blood sugar, blood pressure
    - • Enzymes in the pancreas
Drug interactions
Dose adjustment is required when used with –
- - - • Anticonvulsant drugs
    - • Cardiovascular drugs
    - • Antihypertensive
    - • Anti-fungal and
    - • Anti-tubercular drugs
    - • Cholesterol-lowering medicines – statins
    - • Various herbal formulations – ergotamine derivatives
    - • Sedatives
    - • ED Medicines
    - • Contraceptive medicines
Warnings
To be used under medical prescription.
Do not discontinue abruptly in Hepatitis B patients – may cause serious liver flare-ups
It should be avoided in severe liver dysfunction.
It should not be used in children.
It should not be given to women who are feeding children.
It should not be used in pregnancy.
Allergy with the drug.
Conclusion:
Lopinavir/Ritonavir, Lopikast is a strong antiviral drug combination. It is a newer combination offering better control over HIV load.
It inhibits disease progression.
Strict adherence to the therapy is required to control HIV.

Lopinavir and Ritonavir USP Tablets