Methotrexate Injection

Methotrexate Injection

Methotrexate 50mg /2ml

Classification: Anticancer Medicine

What is Methotrexate Injection?

Methotrexate injection is an anticancer drug and also an effective immunosuppressant. It is used in the oncology care setting to treat different female cancers, head and neck cancers, and blood cancers. It is also used to treat immune disorders.

Uses of Methotrexate Injection

It is widely used in hospitals and cancer treatments:

• • Breast Cancer
• • Leukemia
• • Lymphoma
• • Arthritis
• • Psoriasis
• • Juvenile arthritis

What is Trexazer 50mg?

Trexazer is a methotrexate injection 50mg/2ml. Traxezer is widely used in oncology care settings and cancer hospitals to treat advanced forms of breast cancer.

Trexazer is also used end ectopic pregnancy.

Aprazer Healthcare – Advancing Cancer Care Treatments

Aprazer Healthcare is the anticancer injection manufacturer and exporter.

We are the top manufacturers of advanced anticancer treatments and medicines. Hormonal therapy drugs, Targeted therapy drugs, and chemotherapy medicines.

Aprazer manufactures a range of generic and branded oncology injections.

We develop a wide range of injectable solutions, lyophilized injection preparations, pre-filled syringes, and RTU-technology anticancer injections.

Working of Methotrexate Injection

It inhibits the formation of folic acid, which is used by the cells to multiply and replicate.

It causes cancer cell death.

It inhibit the formation of DNA.

It reduces the immune activity of the cells.

Methotrexate Injection Common Side Effects

Methotrexate is a strong anticancer medicine and also affects healthy cells.

It causes several side effects that go away over time.

• • Nausea
• • Vomiting
• • Ulcers and mouth sores
• • Diarrhea
• • stomach ache
• • weakness
• • Headache
• • Dizziness
• • Fall in blood count
• • Loss of hair
• • Sun sensitivity

Methotrexate Injection: Serious Side Effects

It causes serious blood side effects and toxicities.

The risk of serious side effects increases with the dose.

• • It lowers body’s immunity.
• • It elevates the risk of infection.
• • It lowers blood count.
• • It lowers red blood cells.
• • It causes jaundice, hepatic toxicity.
• • It increases lung inflammation.
• • It can cause shortness of breath, dry cough, etc.
• • Skin reaction causing blisters, bruising.
• • Changes in urination increase the risk of CKD.
• • It leads to seizures, confusion, and even fainting.

Precautions for Using Methotrexate Injection

It should be used cautiously in people having illnesses or organ dysfunction.

It should be carefully used in people with:

• • Kidney dysfunctions
• • Liver disorders
• • bleeding disorder
• • Having other infections
• • People should avoid alcohol.
• • Driving should be avoided.
• • Sun exposure should be avoided.
• • People should maintain contraception during the treatment.
• • Folic acid supplementation is required as it lowers folic acid formation.

Warnings for Methotrexate Injection

• • It should be, after the doctor’s advice.
• • It should not be used in pregnancy.
• • It should not be used by a mother feeding the baby.
• • It should not be used in an allergy to the drug.

Drug Interactions

It should not be used in combination with other drugs:

• • NSAIDS
• • Antibiotics
• • Antacids
• • Live vaccines

Storage Conditions

• • It should be stored at 20-25 degrees Celsius.
• • It should always be kept away from light.
• • It should not be freezed.
• • Keep away from moisture.

Monitoring Considerations

Use of methotrexate injection should be monitored for:

• • Kidney functions
• • Signs of infections
• • Liver functions
• • total blood count
• • risk of bleeding
• • Severe skin rashes

Administration Instructions

Methotrexate is given through different modes of administration:

• • Subcutaneous mode – it is given under the skin, when used for an autoimmune disease.
• • For cancer treatment, it is given as Intravenous infusion, intramuscular, or intrathecal.

Leucoverin – Methotrexate Rescue Therapy

When methotrexate is used in higher doses for cancer. It affects the healthy cells. It lowers the folic acid formation in the body.

Leucoverin infusion is given to revive healthy cells. It is folinic acid.

Note: Methotrexate injection should be used cautiously in people with bleeding disorders as it can cause severe suppression of bone marrow.

It should always be supplemented with folic acid.

It leads to folate deficiency.