Paclitaxel Injection Suspension
Paclitaxel Injection Suspension
Classification: Anticancer Medicine
What is paclitaxel Injection Suspension?
It is the injection that is bound to the human albumin. It is widely used in healthcare settings and the oncology departments to treat various cancers.
What are the uses of paclitaxel Injection Suspension?
It is widely used to treat local, advanced cancers and the cancers that have failed first-line therapy.
- • Advanced breast cancer
- • Pancreatic cancer
- • Non-small cell lung cancer
Why Nab-paclikast is the best paclitaxel injection suspension?
Nab- paclikast is the leading human albumin-based paclitaxel suspension. It is widely used in cancer care therapies and anticancer regimens. Nab-paclikast suspension eliminates the need for pre-medication with steroids and other corticoids.
Nab-paclikast is a human protein-bound paclitaxel preparation that does not contain co-solvent and lowers the risk of hypersensitivity or allergies.
Aprazer Healthcare – Innovative Anticancer Drugs and Injections
Aprazer Healthcare is the leading cancer medicine manufacturer, simplifying cancer care therapies. Developing nanoparticle suspensions, lyophilized solutions, we are the leading anticancer injection manufacturers, supplying worldwide.
Working of Paclitaxel Injection Suspension
The paclitaxel suspension inhibits spindle formation. It inhibits the mitotic process, causing cancer cell death. It disrupts the cell division process, causing cell cycle arrest.
Common Side Effects of Paclikast Injection Suspension
The side effects are caused by paclitaxel’s effect on rapidly dividing cells. It affects the blood cells, hair cells, and nerve cells.
- • It lowers the blood count.
- • It causes Anemia
- • Peripheral neuropathy
- • Diarrhea
- • Decrease in appetite
- • Mouth sores
- • Hair loss
- • Fluid retention
- • opportunistic infections
Serious Side-Effects caused by Paclitaxel Injection
Paclitaxel can cause various serious side effects, as it inhibits the rapidly dividing cells. The serious side effects depend upon the dose or are cumulative, as caused by additive doses.
The side effects include-
- • Severe Myelosuppression – paclitaxel causes bone marrow depression, which suppresses the formation of blood cells, leading to anemia, unusual bleeding. The reduced platelets and neutrophils lead to an increased risk of infections.
- • Nerve Damage – The high dose of paclitaxel causes nerve damage, release of cytokines leads to inflammation.
- • Difficulty in Breathing – The higher doses of paclitaxel cause injury to the lungs, causing insufficiency in breathing.
- • Allergy and Hypersentivity – Any exciting allergy to taxanes can lead to a severe reaction.
- • Cardiac Problems – It can cause irregular heartbeat and severe heart issues in people having cardiac insufficiency or other medical conditions.
- • Liver Damage- It may lead to liver damage in pre-existing liver disorders.
- • Local Tissue Damage – It can irritate the vein and cause necrosis.
Precautions to be used while using Paclitaxel
The administration of paclitaxel injection should be carefully monitored for its side effects, causing low blood count and hypersentivity reactions.
It should be cautiously used in people with –
- • Hepatic Impairment
- • Cardiac diseases
- • Neurological conditions
- • Infections
- • Any allergy to the taxane alkaloid
- • Due to its toxic effects, it should be handled carefully in hospital settings.
- • The proper means of contraception should be used during the treatment.
Warning
- • It should not be used without a doctor’s advice.
- • It should not be used in allergy or hypersensitivity.
- • It should not be used in pregnancy or breastfeeding.
Important Monitoring Considerations
The paclitaxel suspension should be carefully monitored for long-term and dose-dependent side effects. The therapy should be carefully monitored for various body functions, especially during the first hour of the infusion.
- • Blood pressure
- • Irregular heartbeat
- • Complete blood count
- • Heart functions
- • Infection signs
- • Breathing problems
Storage
- • It should be stored at 2-8 degrees Celsius.
- • It should be protected from light.
- • The lyophilized powder should be stored at room temperature.
Administration Instructions
- • The Paclitaxel injection should be administered as a slow infusion.
- • The reconstituted injection should be used immediately.
- • It should not be stored for more than 8 hours in the refrigerator after reconstitution.
Conclusion
Paclitaxel Injection suspension is widely used in oncology care settings. It should be used carefully for dose-dependent side effects and effectively regulated and monitored for therapeutic doses.
