Paclitaxel Injection Suspension

Classification: Anticancer Medicine

Overview

This formulation is a protein-bound paclitaxel preparation, primarily used in oncology care to target different cancer types. It is bound with human albumin, enhancing delivery and reducing the need for steroid pre-medications.

Primary Uses

• Advanced breast cancer
• Pancreatic cancer
• Non-small cell lung cancer

Why Choose Nab-Paclikast?

Nab-Paclikast is a leading albumin-bound paclitaxel suspension. It eliminates the need for additional steroid pre-medications, lowers the risk of hypersensitivity, and improves treatment outcomes in various cancer regimens.

Mechanism of Action

The suspension works by disrupting spindle formation during cell division. It blocks the mitotic process, causing cell cycle arrest and eventual cancer cell death.

Common Side Effects

• Low blood cell counts
• Anemia and fatigue
• Neuropathy (nerve pain)
• Loss of appetite
• Hair loss
• Mouth ulcers
• Diarrhea and fluid retention
• Higher infection risk

Serious Adverse Reactions

• Severe bone marrow suppression (leading to bleeding & infection risks)
• Nerve damage and inflammation
• Breathing difficulties at higher doses
• Allergic or hypersensitivity reactions
• Cardiac rhythm problems
• Possible liver injury
• Localized vein irritation and necrosis

Precautions

Administration should always be supervised in oncology centers. Patients with pre-existing liver, heart, or neurological conditions require close monitoring. Effective contraception and careful handling in hospital environments are strongly advised.

Warnings

• Not recommended during pregnancy or breastfeeding
• Should only be administered under medical supervision
• Contraindicated in patients with known allergy to taxanes

Monitoring Parameters

• Regular blood counts
• Heart function and blood pressure checks
• Monitoring for infections
• Respiratory health during infusion

Storage & Administration

Store at 2–8°C, away from direct light. The lyophilized form can be kept at room temperature. Once reconstituted, the injection should be used immediately and not stored beyond 8 hours. It is administered as a controlled, slow infusion.

Conclusion

Paclitaxel Injection Suspension remains an important option in cancer therapy. With careful dosing, monitoring, and adherence to precautions, it provides effective management of several advanced malignancies.