Tacrolimus Capsules

Tacrolimus Capsules

Classification – Organ Transplant Medicine

What are Tacrolimus Capsules for?

It is used in the leading hospitals and surgical centers.
It is used to suppress –
The immune system of the body.
Prevent organ rejection in transplant surgeries.

Tacrolimus Capsules Uses

Tacrolimus is widely used in –

Prophylaxis for organ transplant.

• • Kidney transplant
• • Heart transplant
• • Liver transplant

What Are Xgraf 1 Capsules?

Xgraf-1 is manufactured by Aprazer Healthcare.
It is used worldwide for the preparation of the body before surgery.
Xgraf-1 is a widely used Kidney transplant medicine.

Other Strengths Include-

• • Xgraf- 0.5 – Tacrolimus 0.5mg
• • Xgraf – 2 – Tacrolimus 2mg

Aprazer Healthcare- As the Top Nephrology Drug Manufacturer from India

Aprazer Healthcare is the top Indian Organ transplant medicine manufacturer.
Ranking as the leading Nephrology drug manufacturer, Aprazer Healthcare is the leading kidney transplant medicine manufacturer.
Exporting transplant medicines worldwide, Aprazer is the top Tacrolimus capsules exporter.
We manufacture global quality post-transplant care medicines, affordable and accessible worldwide.

Working of Tacrolimus Capsules

It inhibits the action of immune cells.
It prevents rejection of the graft.
It inhibits the body’s reaction to the new organ.

Why Take Tacrolimus Capsules?

• • It reduces the risk of acute rejection
• • Strong immune-suppression
• • Long-term graft survival
• • It lowers the need for steroids.

What Are the Tacrolimus Capsules’ Side Effects?

The common side effects are caused due to immune suppression-

• • High blood pressure
• • High potassium levels
• • Tiredness
• • Excess hair growth
• • GIT upset – diarrhea, nausea
• • Headache

What Are Tacrolimus Capsules’ Serious Side Effects?

Tacrolimus can cause severe side effects because-
• It constricts blood vessels.
• Affect metabolic functions.
• Severely lowered immunity.

Kidney damage – It causes toxicity. It constricts blood vessels.
Neurotoxic side effects – It inhibits synaptic transmission.
Liver dysfunctions – Jaundice, yellowish urine, and skin
Risk of severe infections.
Heart complications- QT prolongation, irregular heartbeat
Metabolic dysfunction – onset of diabetes mellitus
Long-term immune suppression

Precautions With Tacrolimus Capsules

The proper dose should be adjusted in patients with –

• • Bleeding disorders
• • Liver disorders
• • Kidney diseases
• • Active infections- HIV, Hepatitis
• • Diabetics
• • Hypertension patients
• • Neurological disorders
• • Electrolyte imbalances

What Should Be Avoided With Tacrolimus Use?

Planning a pregnancy must be delayed.
It should be used carefully in the elderly.
Live vaccines should not be used.

Warnings for Tacrolimus Capsules

To be used under a doctor’s advice.
Do not use in-

• • Breastfeeding women
• • Pregnant ladies
• • Allergy to the drug

Drugs That Cause Toxicity With Tacrolimus Capsules

It can cause kidney toxicity.
It impairs the enzyme binding in the liver or intestine.

• • Antiviral
• • Antibiotics
• • TB medicines
• • And other immunosuppressants
• • Cardiovascular drugs –calcium channel blockers
• • Antifungal
• • Grapefruit juice
• • Anticonvulsants

Important Monitoring Considerations for Tacrolimus Capsules

Tacrolimus requires dose adjustment and monitoring for side effects.
It requires monitoring of –

• • Total blood count
• • Liver functions
• • kidney functions
• • Electrolyte levels
• • Neurological functions
• • Blood pressure, blood glucose
• • Cardiac functions

Conclusion

Tacrolimus is a common immune suppressing medicine.
It should be carefully monitored for
Tacrolimus capsules should be taken with a large amount of water.
The medicine should not be stopped without the doctor’s consent.