Description
Description
Lapakast -250 mg
Composition: Lapatinib Ditosylate IP -250mg
Therapeutic Class: Antineoplastic
What is Lapakast?
Lapakast is an anti cancer medicine that is used orally against solid tumors and breast cancers.
Uses of Lapakast –
- • Advanced-stage Breast cancer
- • Metastatic Breast Cancer
- • Lung cancer
How does Lapakast work?
- • It causes programmed cell death by inhibiting HER-2 and EGFR receptors.
- • It inhibits signals for cancer cell growth and division.
Common side-effects
- • Anorexia
- • Diarrhea
- • Skin rashes, itchiness
- • Stomatitis, constipation, and abdominal pain
- • Palmar-plantar erythrodysaesthesia
- • Pain in the extremity, back pain
- • Hair loss
Serious side-effects
- • Bleeding in the stomach
- • Dehydration
- • Electrolyte imbalance
- • QT prolongation
- • Hand and foot syndrome
Toxicities
- • Cardiac toxicities
- • Hepatotoxicity
- • Interstitial Lung Disease
- • Pneumonitis
Contraindications
Not to be used in patients –
- • Hypersensitive or allergic to the drug or its excipients.
- • Breastfeeding mothers
- • Pregnant women
Precautions
To be used cautiously in patients with
- • Heart disease
- • Low blood count
- • Liver disease
Warnings
To be used under medical supervision
Important Safety and Monitoring Information
Regular monitoring is crucial for patient safety and treatment efficacy –
- • The liver function – AST, ALT, bilirubin, alkaline phosphatase
- • Cardiac function – periodic assessment of left ventricular ejection
- • Electrolyte balance – potassium, magnesium levels
- • GIT disturbances – hydration status
- • Regular blood count – Complete blood count
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