Xgraf 0.5

Xgraf 0.5

Composition: Tacrolimus- 0.5mg

Classification: Antirejection Medicine

Xgraf: Trusted Graft Protection

Xgraf is widely accepted and used for organ transplant protection to effectively protect grafts, eliminate the immune response after transplantation.

Aprazer Healthcare: Affordable Kidney Transplant Medicines

Aprazer offers an unparalleled range of life-saving medicines, with world-class infrastructure and advanced manufacturing facilities, developing a range of premium quality nephrology medicines.

• • World-class manufacturing Infrastructure
• • International Quality Standards – WHO-GMP certified
• • Affordable Medicines
• • Research-driven formulations
• • Available in 50+ countries

What is Xgraf?

Xgraf is an organ transplant medicine, widely used for post-transplant care and prophylaxis of organ rejection.

Uses of Xgraf

• • Prophylaxis for organ transplant
• • Post-transplant therapy – Kidney transplant
• • Liver transplant
• • Heart transplant

How does Xgraf work?

It suppresses the activity of T cells and lowers the immune response.

Accepts the organ transplants.

Benefits

• • Faster onset
• • Potent immune-suppression
• • Long-term graft survival

Common Side Effects

• • Increases creatinine
• • Skin rashes
• • Headache
• • GIT upset
• • Nausea, diarrhea
• • High calcium levels
• • Low potassium levels
• • Tiredness

Serious Side Effects

• • Renal toxicity
• • Severe infections
• • Seizures, encephalopathy
• • Bone marrow suppression
• • Metabolic dysfunctions
• • Cardiovascular side effects
• • Arrhythmias, high blood pressure
• • Post-transplant lympho-proliferative disorder (PTLD)

Precautions

To be used cautiously used in-

• • Elderly Patients
• • Bleeding disorders
• • Liver disorders
• • Kidney diseases
• • Active infections – HIV, Hepatitis
• • Diabetics
• • Hypertension patients
• • Neurological disorders

Safety Instructions

• • Maintain contraception during the treatment
• • Avoid live vaccines (MMR, Varicella) due to a compromised immune system

Contraindications

• • Should not be used in pregnant women and breastfeeding mothers
• • Hypersensitivity or allergic reaction to the drug or its excipients

Warnings

To be used under medical prescription.

Drug Interactions

• • Antiviral
• • Antibiotics
• • TB medicines
• • Other immune suppressants
• • Cardiovascular drugs – calcium channel blockers
• • Antifungal
• • Grapefruit juice

Important Monitoring Considerations

Monitor for –

• • Total blood count
• • Liver and kidney functions
• • Neurological functions
• • Blood pressure, blood glucose
• • Cardiac functions
• • Therapeutic Drug Monitoring is required as it has a narrow safety margin