Xgraf 1

Xgraf 1

Composition: Tacrolimus – 1mg

Classification: Organ Transplant Medicine

Xgraf: Trusted Long-term Transplant Medicine

Xgraf is widely used and highly prescribed for post-transplant care worldwide in nephrology care settings.

Aprazer: World-Class Manufacturing Infrastructure

Aprazer Healthcare, advancing kidney treatment, manufactures international standard, premium quality medicines, and is the largest manufacturer and exporter of nephrology medicines.

• • WHO-GMP certified
• • Affordable Medicines
• • Research-driven formulations
• • Available in 50+ countries

What is Xgraf?

It is an anti-rejection medicine, a widely used immunosuppressant for organ transplant therapy.

Uses of Xgraf

• • Prophylaxis for organ transplant
• • Post-transplant therapy – Kidney, Liver, Heart transplant

How does it work?

It suppresses the immune activity of T lymphocytes, and the body accepts the foreign organ.

It reduces immune flare or rejection.

Benefits

• • Faster onset
• • Potent immune-suppression
• • Long-term graft survival

Common Side Effects

• • Kidney dysfunction – Increases creatinine
• • Skin rashes and ulcers
• • Headache
• • GIT upset
• • Nausea, diarrhea
• • High calcium levels
• • Low potassium levels
• • Tiredness

Serious Side Effects

• • Renal toxicity
• • Severe infections
• • Seizures, encephalopathy
• • Bone marrow suppression
• • Metabolic dysfunctions – hepatotoxicity
• • Cardiovascular side effects
• • Arrhythmias, high blood pressure
• • Post-transplant lympho-proliferative disorder (PTLD)

Precautions

To be used cautiously used in-

• • Elderly Patients
• • Bleeding disorders
• • Liver disorders
• • Kidney diseases
• • Active infections – HIV, Hepatitis
• • Diabetics
• • Hypertension patients
• • Neurological disorders – depression, anxiety
• • Pre-existing Malignancies
• • Electrolyte imbalances

Safety Instructions

• • Maintain contraception during the treatment
• • Avoid live vaccines (MMR, Varicella) due to a compromised immune system

Contraindications

• • Should not be used in pregnant women and breastfeeding mothers
• • Hypersensitivity or allergic reaction to the drug or its excipients

Warnings

To be used under medical prescription.

Drug Interactions

• • Antiviral
• • Antibiotics
• • TB medicines
• • Other immune suppressants
• • Cardiovascular drugs – calcium channel blockers
• • Antifungal
• • Grapefruit juice

Important Monitoring Considerations

Monitor for –

• • Total blood count
• • Liver and kidney functions
• • Therapeutic Drug Monitoring is required as it has a narrow safety margin