Diabetic Neuropathy Treatment and the Drugs
It is nerve damage because of high sugar levels.
Nerve damage can occur in the legs, hands, and internal organs.
Why does high blood sugar damage the nerves?
The high levels of circulating sugars clog the thin blood vessels.
This blocks the supply of blood to the nerves.
- It inhibits the oxygen supply to the nerves.
- It leads to oxidative stress.
- Sorbitol buildup causes fluid accumulation inside the nerve cells.
- Breaks down the myelin sheath.
- Interrupts nerve conduction
The types of Diabetic Neuropathy –
Peripheral nerve damage – The nerves of the hands, arms, and legs get damaged.
Autonomic Neuropathy- The nerves of the internal organs get damaged.
It can be the nerves of the digestive system, urinary bladder, and heart.
Proximal Neuropathy- It is nerve damage in the hip, buttock, thighs, or legs.
It occurs as severe pain and muscle weakness.
Focal Neuropathy-
A specific nerve gets damaged.
What are the symptoms of diabetes damaging the nerves?
Peripheral nerve damage-
Nerve damage in the peripheral organs.
Hands and legs
- Tingling pain
- Needle-like feeling.
- Burning, sharp pain
- Numbness
- Poor balance
- Muscle weakness
Autonomic nerve damage –
The nerve damage affects internal organs –
Like the stomach, heart, and bladder.
- Stomach upset
- Diarrhea /constipation
- Inconsistent urination
- Hypotension
- Sexual problems
- Unusual Sweating or no sweating.
Which pain-relieving medicines are used to treat diabetic neuropathy?
These are widely used to relieve neuropathy pain.
- Anticonvulsants –
These calm the nervous system.
It reduces the sharp pain.
- Antidepressants – It lowers the spinal cord or brain signals.
- Topical anesthetics- These are local anesthetics.
These are used for local pain relief.
How to manage diabetic nerve damage?
The various steps to manage nerve damage.
- Keep blood sugar within range.
- Avoiding injuries
- Using pain-relief medicines
- Practice hygiene and foot care
- Limit alcohol /smoking
- Low-impact exercises
Why are NSAIDs ineffective in neuropathic pain?
NSAIDs have limited use in managing diabetes induced pain.
They target inflammation.
They cannot relieve pain caused by changes in nerve signals.
It also increases the risk of toxicity.
- Kidney damage
- High blood pressure
- Fluid retention
- Stomach irritation /ulcers
Which is the leading contract drug manufacturer of Neurology Drugs?
Aprazer Healthcare is the top pharmaceutical company.
We manufacture a global range of pharmaceutical products.
We are the leading drug exporters worldwide.
We export neurology drugs to Asia, Africa, and America.
Our neurology product portfolio consists of –
- Anticonvulsants
- Neuroprotective combinations
- Venotonic medicines
