India meets the global demand for anticancer medicines, with robust Research and Development facilities, developing new drug moieties, leading expertise, adapting the evolving regulatory standards.

With the State of Art Infrastructure

Indian companies contribute to investing in the latest drug development, developing formulations with a patient-centric approach to enhance efficacy and better safety.

Clinical Research

India conducts the majority of clinical trials for Novel Drug Discoveries.

• • India has a diverse genetic pool.
• • High-quality data collection and accountability.
• • Government supporting and funding pre-clinical and clinical research.

Government Approvals and Regulatory Support

Fast track government approvals, reduction in review time and waiver for local trials.
CDSCO provide provision for accelerated reviews for patented drugs, conditional approvals and relaxation for local trials.

Assured Quality and Safety

Strict Post market surveillance and pharmacovigilant standards for the manufacturing companies to address patient safety and therapeutic efficacy.

Globally Approved Manufacturing Capabilities

Facilities that meet the international regulatory standards and GMP practices.

High Demand for Indian Oncology Medicines?

Indian oncology products are in high demand due to:

Affordability

• • Low operational cost
• • low labor cost
• • Drug pricing controls by the national pharmaceutical pricing authority to meet the global demand.

Advanced Therapy

Indian companies invest in developing Novel drug therapies in oncology care:

• • Biosimilars
• • Patented biologics and antibody conjugates,
• • Drugs targeting genetic mutations,
• • Drugs modifying immune responses.
• • Targeted therapies

Global Partnerships and Collaborations

Indian pharmaceutical manufacturers actively collaborate with global pharmaceutical companies and develop strong distribution networks and facilitate research and drug development.

Export and Global Expansion

Penetrating the emerging markets, the Indian anticancer drugs has the widest rich:

• • Africa
• • South East Asia
• • CIS countries
• • South America
• • European countries

Aprazer Healthcare –Top Oncology Drug Exporters and Manufacturers from India

Develops the widest range of anticancer drugs focused on new drug development:

• • Chemotherapy drugs
• • Targeted therapies
• • Immunotherapy
• • Hormone therapy

Global Reach

Present across more than 50 countries across the globe, we have strong footprints in Africa, South America, Southeast Asia, and CIS countries.

Adherence to International Standards

WHO-GMP, EU-GMP certified facilities and strict adherence to the evolving regulatory standards.

Competitive Pricing and Consistent Quality

Streamlined manufacturing process, continuous production, minimizing wastage, implementing the cutting-edge technology, we assure the best quality and potent therapeutic efficacy.

Collaborations and Partnerships

Committed to affordable patient care, we have extensive partnerships in hospitals, government healthcare programs, dispensaries, healthcare centers, clinics and healthcare professionals.

Partnerships with more than 150 clients across the globe, we collaborate with the global pharmaceutical innovators and investors, cross-selling our products across the world markets.

HIV has always been a menace to mankind, but the condition changes; knowing HIV is manageable, though not curable. The future of HIV treatments aims at managing HIV 100% and living a fulfilling life. Anti-retroviral therapies and combinations are increasing life expectancies and the quality of life.

How Does HIV Harm the Body?

• • Attacks CD4 cells
• • Damages CD4 cells
• • Down-regulates the immune system

It mimics the DNA and rapidly produces its cells, utilizing innate metabolic processes.

Step-by-Step Invasion by HIV

• • HIV binds to the surface of CD4 cells.
• • Enters the CD4 cell.
• • Converts HIV RNA into HIV DNA.
• • Through the HIV integrase enzyme, it integrates its viral DNA into the CD4 cell DNA.
• • After integration, it replicates using CD4 DNA proteins to create viral RNA and proteins.
• • After producing copies, HIV steps out of the CD4 cells, damaging them and then infecting other CD4 cells.

Anti-Retroviral HIV Therapy?

The combination of antiretroviral drugs:

• • Reduces the HIV load
• • Increases CD4 cell count
• • Restores the body’s immunity

CD4 cells are destroyed by HIV, weakening the immune system and making the body prone to opportunistic infections and negative health effects.

How do HIV Medicines Work?

• Entry/Fusion Inhibitors: Inhibit membrane fusion and viral entry into CD4 cells.
• Reverse Transcriptase Inhibitors: They inhibit reverse transcriptase, thus block the conversion of RNA to DNA.
• Integrase Inhibitors: They inhibit the integrase enzyme from integrating Viral DNA into the CD4 DNA.
• Protease Inhibitors: Inhibit the protease enzyme and viral budding from the infected CD4 cells to invade another CD4 cell.

Primary Goals of HIV Treatment?

• • To reduce the HIV count
• • To restore the immune system
• • Prolong survival
• • Reduce transmission

Why is it so Important to adhere to HIV Therapy?

HIV treatments mandate –lifelong antiretroviral regimen.
Adherence to HIV medicines –

• • Suppresses the virus
• • Reduces mutation capacity
• • Reduces drug resistance

Missing doses may increase the risk of –

• • Relapse
• • HIV mutations
• • Treatment failure and,
• • Transmission

Why is there a need for combination drug therapy for HIV?

The combination therapy blocks HIV multiplication at various stages, offers more protection, and potent effect.

The combination therapy also reduces drug resistance and is used for long-term effects.

The Potent Drug Combinations for HIV Treatment?

• Virazer: Tenofovir Disoproxil Fumarate, Emtricitabine & Efavirenz
• Tudobest-L: Tenofovir Disoproxil Fumarate & Lamivudine
• Temirazer: Tenofovir Disoproxil Fumarate & Emtricitabine
• Tudobest-LE: Tenofovir Disoproxil Fumarate, Efavirenz & Lamivudine

Aprazer Healthcare leads the way in manufacturing premium quality HIV medicines with world-class manufacturing infrastructure.

Chemotherapy

Chemotherapy is a cancer treatment that consists of a single drug or a combination of drugs to reduce the growth of cancer.
Cancer cells divide rapidly, and chemotherapy inhibits their division and propagation by damaging DNA or the signaling pathways.

The Need for Chemotherapy

It is used at different times to treat cancers:

• • Before surgery, it reduces the risk of cancer.
• • After the surgery, to eliminate the cancer cells left during surgery.
• • Palliative care to lessen the symptoms.

Types of Chemotherapy Treatment

• Hormone Therapy: It is used to treat cancers dependent upon hormones for growth and proliferation. The drugs consist of hormone receptor analogues.
• Immunotherapy: It consists of drugs used to elevate the immune system to recognize at downregulate cancer cells.
• Targeted Therapy: It consists of drugs that target the cancer cells without harming the normal cells.

The Duration of Chemotherapy Treatment

The duration of chemotherapy depends on the type, stage, and location of cancer.

• Short-Term Therapy: It usually extends from 3 to 6 months for early-stage cancers, the treatment cycles occur every 2 to 3 weeks.
• Long-Term Therapy: It’s the longer treatment process that extends from 6 months to years. It is used for metastatic or advanced-stage cancers.
• Maintenance Chemotherapy: It is an ongoing treatment to prevent the return of the cancer, and it lasts for several months or years.

What Are Chemotherapy Cycles?

Chemotherapy is always given in intermittent breaks to reduce side effects and maximize the effectiveness of treatment.

• Treatment Phase: The duration during which chemotherapy is administered intravenously or orally.
• Rest Phase: The break or the rest period, so that the body can regenerate or recover healthy cells.

Why Should You Not Skip Chemotherapy Cycles?

Skipping chemotherapy may pose serious consequences on patient health and treatment outcomes.

• • Reduced Treatment Outcome: Skipping the chemotherapy cycle reduces the effectiveness of treatment and its ability to kill cancer.
• • Potentiate Cancer Growth: Skipping doses increases the risk of cancer proliferation, and cancer grows again during the gap period.
• • Drug Resistance: It may increase the risk of drug resistance; the body would stop responding to the drug.
• • Prolonged Side Effects: The side effects usually fade during an intermittent period; delaying or skipping the process delays the recovery period, causing side effects to extend longer.
• • Harder to Treat Cancer: Missing doses may allow cancer to aggravate or grow, which may not be able to be controlled later.

Recovery After Chemo

The chemotherapy side-effects depend on the duration of the treatment and the type of the drug.

The short–term side effects are eliminated as soon as chemotherapy is stopped, including nausea, hair loss, and diarrhea.

Long-term side effects last from months to years, including tiredness, brain fog, numbing of feet, hands, weight gain or loss, fertility issues, heart troubles, and mood changes.

Safety Guidelines for Chemotherapy

After every chemotherapeutic cycle, the white blood cell counts fall, and the next cycle is awaited for the white blood count to recover.
If the body doesn’t recover the neutrophil count, the cycle is delayed. It constitutes almost a rest period of 7 days.

Drugs Used in Chemotherapy

• Abirakast (Abiraterone acetate): used in prostate cancer for progesterone
  inhibition.
• Indenza (Enzalutamide): A hormonal therapy drug for castration prostate cancer.
• Inlybest (Axitinib): Used in endothelial cell carcinoma of the kidney.
• Lenvakast (Lenvatinib): In thyroid, renal, and hepatocellular carcinoma.

Conclusion

Chemotherapy brings effective outcomes when used judicially with strict treatment adherence. It’s the cornerstone for both curative and palliative cancer treatments.