Diabetes does not remain confined to increased blood sugar.

Over the years, diabetes damages your kidneys silently.

Diabetes continues to be a leading cause of kidney failure. 

Controlled sugar levels reduce disease progression.

However, it does not eliminate the risk.

Let’s understand the link between diabetes and kidney damage. 

Early identification can be a preventive approach.

It can stop the progression of the disease to an end-stage kidney disorder.

Focused on kidney disease treatments and prevention, Aprazer Healthcare manufactures a range of affordable nephrology medicines.

We are the leading nephrology drug manufacturer, exporting kidney medicines worldwide.

Our product portfolio consists of –

• Anti- diabetic combinations 

• Kidney transplant medicines 

• Nephrology and diuretics 

How does diabetes damage kidneys?

High blood sugar is often accompanied by high blood pressure.

The kidney damage occurs through several mechanisms –

Hyperfiltration and mechanical stress- 

Chronic high sugars strain the tiny blood vessels.

It increases kidneys to work harder.

The kidneys stop filtering proteins.

The proteins leak into the urine.

Damaged blood vessels- 

The increased glucose stiffens the blood vessels.

It thickens the blood and induces clogging.

Nerve damage- 

It damages the nerves of the bladder.

It leads to buildup of back pressure on the kidneys.

It also increases the risk of UTI.

Scarring – The injury to the nephrons slowly leads to scarring.

It destroys the ability to filter blood.

What are early signs of kidney damage, a diabetic must never ignore? 

• Foamy urine – 

It indicates that the filtering capacity of the kidneys is damaged.

The kidney is not able to retain proteins.

The proteins are directly excreted into the urine.

• Edema – 

It is the swelling in the feet, hands, and ankles. Puffy eyes.

It is caused when the kidney is not able to excrete the excess fluid or sodium.

It leads to water retention.

The excess fluid leaks from the blood capillaries.

• Increased urination at night 

In conditions of high sugar, the body excretes excess sugar through the urine.

It increases urination. It leads to water depletion.

It increases strain on the kidney cells.

It can damage nephrons.

• Persistent high blood pressure- 

Kidneys regulate blood pressure.

It filters out excess salts and water.

Any damage to the kidneys decreases their capacity to filter.

It increases blood pressure.

• Unusual weight gain 

A person gains excess weight due to fluid retention.

It is not the muscle weight; it’s the weight of the water retained in the body.

Long-term warning signs – 

• Weakness /fatigue – 

Kidneys produce a hormone that forms blood.

The damage to the kidney leads to reduced formation of blood.

It leads to –

• Anemia
• Chronic weakness
• Changes in taste, nausea – 

The unfiltered blood leads to toxin buildup in the blood.

It causes metallic taste or vomiting.

• Edema in the lungs 

Fluid builds up in the lungs.

It causes difficulty in breathing.

It leads to shortness of breath.

• Muscle cramps /pain- 

Altered kidney filtration leads to electrolyte imbalance.

It leads to increased potassium and magnesium, and low calcium.

Acid- base imbalance.

• Increased Insulin Levels- 

Kidneys break down insulin.

The damaged kidneys are not able to metabolize insulin.

It causes an increased level of insulin.

Conclusion – 

Know your kidneys; kidney disease is silent.

The damage reaches the advanced stages before the usual symptoms appear.

The early sign is often albuminuria, which starts many years before symptoms.

For a diabetic, it becomes more important to have regular monitoring of the kidneys.

Aprazer Healthcare is a pharmaceutical manufacturer.

With the largest oral solid plant at Haridwar, we are capable of manufacturing different solid dosage forms.

We are equipped with end-to-end continuous manufacturing systems, processing the powdered forms to final coated tablets.

The Triad of Dosage formulation 

A dosage form is as important as the drug itself.

A successful formulation delivers the drug safely and effectively to the site.

It includes an intricate process of-

• Consistent release
• Enhanced absorption
• Drug stability

Different types of Oral dosage forms- 

• Tablets
• Capsules
• Powders and granules

The components of solid dosage formulations- 

API – The active pharmaceutical ingredients.

It gives the therapeutic effect.

Excipients – These are the components used to blend with API.

It enhances its –

• Solubility
• taste
• stability
• shelf life
• compressibility

Finished product – the capsule or tablets that are consumable

Packaging – The tablets or the capsules are dispensed into sealable outer coverings to prevent degradation.

The critical steps involved in manufacturing solid oral dosage forms

Preformulation studies – 

It is the investigational phase.

The physical, chemical, and biochemical properties of the API are studied.

It provides necessary data that helps excipient selection.

Compatibility testing – 

It is the analysis of the interactions between the drug and the excipient.

The API mixture and the selected excipient are subjected to stress testing.

It is passed through analytical testing.

• HPLC
• Differential Scanning Calorimetry (DSC)

Prototype creation- 

A small batch is prepared at laboratory scales.

It is tested for physical prototypes.

• Hardness
• Friability
• Dissolution

Stability and shelf life testing 

It includes accelerated testing.

It is done to predict-

• Shelf life
• Long-term degradation
• Expiry date

Scaling up production 

In this the operational parameters are adjusted.

• Compression force
• Mixing speed
• Drying times

It ensures batch-to –batch consistency and uniform API distribution.

Regulatory dossier preparation

It is the compilation of all the documents for regulatory approvals.

The operational stages include – 

• Weighing /dispensing
• Milling/blending
• Granulation
• Drying /screening
• Compression/encapsulation
• Coating

Aprazer’s expertise in manufacturing oral dosage forms

Meeting the diverse needs of customers, we manufacture small batches to large volume productions.

Equipped with extensive granulation techniques, we are capable of manufacturing compressed tablets to complex dosage forms.

The types of oral dosage forms manufactured at Aprazer Healthcare includes-

• Uncoated tablets
• Film-coated tablets
• Modified release tablets
• Oral dissolving tablets
• Capsules

High blood pressure often remains silent and unnoticed.

However, the rise during pregnancy can severely affect both the child and the mother.

Quick facts –

• Preeclampsia affects 3 to 8 % of pregnancies across the world.
• It accounts for 16% of global maternity deaths.
• It contributes to preterm deliveries in 45% of pregnancy cases.

As the drug manufacturer, Aprazer Healthcare manufactures a range of antihypertensive combinations offering effective, safe BP control.

We are the leading antihypertensive drug exporters from India.

Labetalol (labzer) manufactured by Aprazer Healthcare is globally prescribed for hypertensive control in pregnancy.

Why does blood pressure rise in pregnancy?

Blood pressure rises during pregnancy due to underlying health conditions –

• Obesity
• Smoking
• Having a first pregnancy
• Pregnancy after 40 years of age or before 18 years of age.
• Diabetes
• Chronic diseases
• Pregnancy with twins and triplets

Know the types of hypertension in pregnancy- 

The blood pressure rises after the 20th week of pregnancy.

The high BP ranges above 140mmg hg/90mm hg.

• Gestational hypertension – 

It is the rise in blood pressure without severe complications.

It does not show any symptoms.

It resolves within 12 weeks after childbirth.

• Preeclampsia 

It is a severe rise in blood pressure during pregnancy.

The high BP directly damages the internal organs – Liver /kidney

It can occur before or after childbirth.

• Chronic hypertension 

It is a condition in which the mother already suffers from high BP.

It is caused by underlying diseases.

What are the risks posed by high BP during pregnancy?

• Reduced blood flow to the placenta –

The high BP reduces the flow of blood to the placenta.

It reduces the flow of oxygen and nutrients to the fetus.

• Placental abruption 

The high BP can detach the placenta from the inner wall of the uterus.

It can lead to severe bleeding.

It can be fatal to both the baby and the mother.

• Decreases fetal growth

Improper supply of nutrients restricts the weight and the development of the fetus.

•  Injury to internal organs

High BP may injure the internal organs.

• Premature delivery 

It increases the chances of undeveloped organs in the fetus and before time delivery.

• Risk of cardiovascular diseases 

High BP can increase the risk of getting cardiac complications in the future.

What are the symptoms of high BP while pregnant?

Hypertension is followed by symptoms –

• Persistent high BP
• Severe headache
• Protein in urine
• Vision changes
• Pain in upper abdomen
• Nausea /vomiting
• Fluid retention

Which is the commonly used medicine to control high BP in pregnancy?

Oral Labetalol (Labzer) therapy is used to maintain a steady level.

Labetalol is chosen because –

• Safer profile for both the mother and the child.
• Faster onset of action.
• Fewer side effects
• Dual mechanism of action

It is widely used in blood pressure hovering over a range of –

140/90mm hg and 159/109 mm Hg

It is used as first-line treatment to manage gestational hypertension.

Aprazer Healthcare – The Top Pharmaceutical Drug Manufacturer

Manufacturing over 200 + generic drugs, we are the leading drug exporters and suppliers from India.

We specialize in manufacturing cardiovascular medicines.

Our product portfolio consists of global standard medicines.

• Anti-hypertensive combination
• Lipid–lowering agents
• Anti-lipemic agents

Know the difference- 

They are both erectile dysfunction medicines, often used interchangeably.

Both of them have similar functions and a similar mode of action.

The difference lies in the duration of action.

Tadalafil is widely used for spontaneous sexual activity for a longer time.

Its effect lasts for more than one and a half days.

Sildenafil is used for sexual activity for a short duration.

Its effects last for 4 hours.

When does the doctor prescribe tadalafil /sildenafil?

It is prescribed based on patient history and lifestyle choices.

It depends on the sex frequency.

Those requiring regular sexual activity prefer tadalafil.

On a daily dose basis, doctors prescribe a low dose of tadalafil.

It builds up in the penile tissue and causes spontaneous erections upon arousal.

It is used to maintain constant levels in the body, rather than taking a tablet every day before sex.

Tadalafil can be used to treat BPH along with erection.

Sildenafil is used for a shorter-duration effect.

It has a shorter half-life.

It is eliminated faster from the body.

Those with infrequent sex use sildenafil.

Can I take both together for a stronger erection?

One should not use the 2 tablets together or even take double doses.

It can lead to prolonged painful erections.

An overdose can damage the penile tissue.

It can cause a severe drop in blood pressure.

It can lead to hypotension.

Other side effects include –

Lightheadedness, dizziness, fainting

Tadalafil /sildenafil are available in different strengths – 

Tadalafil is available as –

2.5/5/10/ 20mg.

Sildenafil is available as –

25/50/ 100 mg.

The perfect time to take tadalafil /sildenafil tablet- 

A single tablet is taken 30-60 minutes before performing sex.

For continuous effect, tadalafil is given in short doses of 2.5 or 5 mg daily.

Sildenafil must not be used after a heavy meal.

Tadalafil can be used with/without food.

Aprazer Healthcare- The leading erectile dysfunction medicine manufacturer

As the ED drug manufacturer, we are focused on developing effective medicines to improve men’s sexual health.

We manufacture the widest range of global quality ED medicines.

Recognized as the top drug exporters, we export world-class erectile dysfunction combinations globally.

The widely used ED medicines-

• Viabest-100, Tadabest – Erectile dysfunction medicine
• Super-viabest – Premature ejaculation medicine

Smoking not only increases the risk of pulmonary diseases.

It directly affects muscle strength.

Tobacco use is increasing in epidemic proportions across the world.

82% of adult smokers begin smoking before 25 years of age.

1/5 of the youth start regular smoking by the age of 15.

Delving deep, let’s understand how smoking/nicotine affects muscle strength.

Smoking increases muscle breakdown.

It reduces oxygen delivery to muscles.

The toxic components in tobacco stop muscle formation.

Inhibits protein synthesis –

It stops the synthesis of muscle proteins.

It increases the breakdown of the muscle.

It imbalances muscle formation and muscle degradation.

Impair nutrient synthesis

The rapid muscle breakdown leads to nutrient depletion.

It suppresses the body’s ability to repair muscles.

It reduces muscle strength.

Diminished oxygen supply 

Smoke produces carbon monoxide.

It binds with hemoglobin.

It reduces the binding of oxygen.

The oxygen supply to the muscles/organs is diminished.

Vascular damage 

Smoking causes vasoconstriction.

It stops the formation of new blood vessels.

It increases the risk of clot formation.

Thus interrupting the blood flow.

Hormonal imbalance 

The nicotine present in smoke alters the endocrine hormones.

It increases cortisol levels, increasing muscle breakdown.

Suppressing testosterone reduces muscle build-up.

Systemic Inflammation- 

Long-term smoking infiltrates the blood with cytokines.

It causes a constant state of low-grade systemic inflammation.

It drives muscle wasting.

Does nicotine improves athletics performance?

Nicotine is believed to boost short-term improvement.

However, the long-term side effects outweigh the short-term benefits.

• Nicotine increases the heart rate.
• Improves blood flow.
• It increases motor function.

The chronic use of nicotine has a severe downside.

It leads to dependency.

Athletes are unable to perform without nicotine.

It hijacks the endocrine and sympathetic nervous system.

It leads to a chronic semi-alert state.

It imbalances the transition from performance to recovery.

It impairs-

• sleep quality
• Inhibits muscle repair and formation
• Cognitive function
• Decreases strength and power

Just 14 days of quitting smoking significantly improves muscle endurance.

Over a year of smoking cessation, the body gains up to 17- 23% of muscle strength.

Tips to help muscle growth and strength- 

• Resistance exercises
• Protein-rich diet
• Healthcare supplements

The widely used amino acid supplement used by athletes to improve muscle strength-

Hepakast – L-leucine, L-isoleucine, L-valine (BCAA) sachets, manufactured by Aprazer Healthcare.

These are the branched chain amino-acids essential for muscle building.

• It enhances muscle repair and recovery.
• It reduces muscle breakdown.
• It supports muscle maintenance, providing additional energy.
• It reduces exhaustion during workouts.

Aprazer Healthcare is a pharmaceutical manufacturer. 

We manufacture a wide range of life–saving medicines and healthcare products.

Beyond its specialty in manufacturing oncology medicines, Aprazer Healthcare continues to expand its portfolio, manufacturing a comprehensive range of generics.

Having global footprint, Aprazer Healthcare is a recognized pharmaceutical company, manufacturing global-quality products.

Open to partnerships, Aprazer Healthcare is a global pharmaceutical choice.

HIV treatment usually consists of a combination of 3 drugs.

The two drugs combined from the NRTI class form the foundation.

The other drug forms the basis of the treatment to make it work.

The drugs are from 2 different classes; they effectively inhibit viral cell multiplication at different stages.

These are combined to form a fixed-dose combination.

At Aprazer Healthcare, we are dedicated to manufacturing anti-retroviral combinations, dispensing the multiple drugs into a single pill.

As the leading HIV medicine manufacturer, Aprazer Healthcare manufactures a global range of HIV medicines.

We are the leading HIV drug exporter to countries worldwide.

The anti-retroviral combination forms the gold standard treatment for HIV

The anti-retroviral combination offers –

• Better control
• Lower drug resistance
• Fewer side effects
• Improve immune functions
• Stop transmission
• better compliance
• Lower pill burden

The commonly combined 2 drugs include 

• Nucleotide reverse transcriptase inhibitors (NRTIs)- 

These form the foundation of antiretroviral combinations.

The two drugs are combined to offer a synergistic effect.

These get incorporated into the viral cell.

It inhibits the multiplication of the virus.

• Integrase Strand Transfer Inhibitors (INSTIs)

If the virus manages to form the DNA, integrase inhibitors inhibit the final step.

It stops the virus from integrating its DNA into the human DNA.

Which are the two widely used antiretroviral combinations for HIV?

• Tenofovir and Emtricitabine (Temirazer) – 

It is a widely used combination and forms the backbone of HIV treatment.

Together, they reduce the viral count to zero.

It is also used for pre-exposure HIV prophylaxis.

It can be used for both Hepatitis B and HIV.

Both drugs mimic the nucleic acid bases.

They incorporate into the viral chain and act as chain terminators.

The combination offers a high resistance barrier.

It has a longer intracellular half-life.

• Abacavir and Lamivudine (Abakast-L)- 

It blocks the conversion of RNA to DNA.

They cause chain termination.

It improves immune function.

It inhibits opportunistic infections.

It prevents the transmission of HIV.

Which is better, Tenofovir or Abacavir? 

Both are strong anti-retrovirals.

They both effectively manage HIV.

The choice of treatment depends upon the health profile and viral load.

Tenofovir and emtricitabine (Temirazer) are preferred in –

• High viral load
• Hepatitis B co-infections
• People with cardiovascular risk
• Emtricitabine offers high resistance barrier

Abacavir and Lamivudine (Abakast-L) are preferred in –

• People with risk of renal disorder
• osteoporosis
• It increases cholesterol levels and increases the risk of cardiac problems.

Conclusion – Tenofovir is the first-line treatment, globally preferred combination used to control high viral loads.

Abacavir is the alternative treatment drug widely used in people with renal disorders/bone dysfunctions.

Abacavir therapy requires genetic testing.

The modern HIV drugs are highly effective in managing HIV infection.

They cause fewer side effects, easily manageable.

However the body need time to adjust.

The short-term side effects usually last for 2 – 6 weeks.

The HIV treatment extends life-long and needs strict adherence.

At Aprazer healthcare (HIV medicine manufacturer) we specialize in manufacturing an advanced generation antiretroviral combination.

We are focused to transform multi regimen drugs to a single pill.

We are the top drug exporters supplying a global range of HIV drugs.

Our HIV product portfolio comprises of fixed dose HIV combination drugs.

• Temirazer– Tenofovir Disoproxil Fumarate, Emtricitabine Tablets
• Tudobest-L– Tenofovir Disoproxil Fumarate & Lamivudine Tablets
• Lopikast– Lopinavir and Ritonavir USP Tablets

What are the common HIV drug side effects?

The short term side effects occur during the early weeks of the treatment.

However the body adapts to the drug regimen lowering its adverse effects.

• Stomach upset
• Tiredness
• Low energy
• Trouble falling asleep
• Weird dreams
• Injection site reaction for HIV injectable.

What are the long term HIV medicine side effects?

Cardiovascular /metabolic side effects – 

The HIV medicine increases the level of bad cholesterol.

It increases the risk of plaque deposition in the arteries.

It elevates the risk of heart attack and strokes.

Many of the HIV drugs can directly damage pancreatic cells.

It leads to insulin resistance and increases blood glucose levels.

Body fat redistribution – 

The older generation drugs usually show unequal fat distribution.

The fat under the skin is lost.

The fat accumulates deeper inside the organs.

The belly fat and the buffalo hump.

The thin legs and arms.

Bone –density loss- 

It alters the bone metabolism.

The drugs fasten the bone degradation and stops bone formation.

It increase the risk of fracture.

Organ damage 

Kidney damage – 

The drugs damage the nephrons.

It strains the kidney and impair filtration.

It leads to protein leakage into the urine.

Liver damage 

The drugs leads to elevated liver enzymes.

It increases chronic inflammation.

Nervous system issues 

The prolonged use damages the nerves.

It also leads to neuropsychiatric effects.

Why the side effects of HIV medicines does occurs?

The fixed dose combinations contain more than one drug.

The two or more drugs interact with the body cells at different sites.

Integrase inhibitors can lead to elevated cholesterol or mood shifts.

TDF can affect kidney and bones.

NNRTIs can lead to insomnia or vivid dreams.

Old generation drugs may lead to severe diarrhea, insulin resistance and weight gain.

Rare but severe side effects – 

• Hypersensitivity
• Deep breathing
• Severe muscle pain
• Cold limbs
• Severe peeling, painful skin blisters around mouth, nose or eyes.

What functions must be monitored while on long-term HIV treatment regimen?

3 to 6 months routine checkup is required and complete tests for –

• Blood functions
• Cholesterol
• Blood sugar
• liver enzymes
• Bone density scans

Are these side –effects manageable?

The side- effects are manageable by swapping the regimen.

To reduce kidney /bone issues, one can use tenofovir free regimen.

Integrase inhibitor can increase cholesterol levels.

Allergy /genetic testing.

Secondary medications for cholesterol /diabetes or bone density management.

Lifestyle changes like –

• Strength training
• Proper diet
• Quitting smoke

Sofosbuvir/Velpatasvir (Velakast) is a clinically proven, synergistic combination effective against all major genotypes (1-6) of the hepatitis C virus.

Velakast (Sofosbuvir/Velpatasvir), manufactured by Aprazer Healthcare, delivers an affordable Hepatitis C treatment regimen worldwide.

Aprazer Healthcare (pharmaceutical manufacturer) specializes in manufacturing generic hepatitis C medicines.

We are the largest exporter of hepatitis C medicines from India.

With global-standard drug manufacturing capabilities, we are a trusted, reliable pharmaceutical partner for international drug supplies.

Trusted worldwide by government health bodies, we supply Hepatitis C medicines to the leading global hospitals and clinics.

Why Sofosbuvir/Velpatasvir (Velakast) is widely prescribed? 

It is a globally available strong antiviral combination used to treat tougher cases.

It can be safely used in children above 6 years of age and adults.

It is used in both compensated and decompensated liver cirrhosis.

Sofosbuvir/Velpatasvir (Velakast) combination benefits – 

• The average cure rate is 90-95 percent.
• It offers a high resistance barrier.
• Effective against all types of mutated strains
• Widely preferred in advanced liver diseases
• Single dose combination helps easy adherence.

Velakast usage in co-infections (Hepatitis B /HIV)

It can be used safely in HIV co-infections.

However, in Hepatitis B co-infections, it cannot be used alone.

It can lead to hepatitis B reactivation.

It must be used in combination with Hepatitis B medicines.

What is Sofosbuvir/Velpatasvir (Velakast) standard dose, and how long is the treatment?

The treatment duration depends upon the overall liver health.

The standard treatment lasts for 12 weeks.

In stable cirrhosis, a single tablet (sofosbuvir -400, velpatasvir -100) once a day is used.

For advanced liver disorder, treatment can extend to 24 weeks.

For children, the dose is adjusted as per body weight.

The safe use of Sofosbuvir/Velpatasvir (Velakast) with Ribavirin – 

• Dual drug regimen – 

It is used as a single-dose pill, taken once for 12 weeks in people without cirrhosis or stable compensated cirrhosis.

• Triple drug regimen – 

It is combined with Ribavirin and is used in advanced liver cirrhosis.

Ribavirin maximizes the cure.

It induces self-destruction of the virus.

When is Sofosbuvir/Velpatasvir (Velakast) unsafe in pregnancy?

It is not usually prescribed in pregnancy.

It can be used in conditions of high viral load to prevent transmission to the child.

The triple drug regimen adding ribavirin is highly contraindicated in pregnancy.

It can lead to severe birth defects.

Sofosbuvir/Velpatasvir (Velakast) can cure Hepatitis C. How?

It can achieve 98 percent viral elimination.

One must strictly adhere to the treatment regimen.

Complete the full course.

Do not skip the doses.

Take the medicine at the same time.

Definitive treatments for Hepatitis C by Aprazer Healthcare 

Proton pump inhibitors are commonly available over- the –counter drugs.

These are widely used for quick relief of –

• Heart burn
• Acid-related gastric conditions

Due to easy availability, over-the-counter drugs are mistakenly used for the long term.

What are the commonly available acidity medicines (PPIs)?

• Omeprazole
• Esomeprazole
• Pantoprazole

The widely prescribed PPI combination-

• Eprakast DSR – Esomeprazole ER and Domperidone SR
• Aprapan DSR – Pantoprazole and Domperidone prolonged release capsules
• Aprapan D – Pantoprazole and Domperidone tablets

Aprazer Healthcare, as a gastroenterology medicine manufacturer, manufactures a wide range of gastrointestinal drugs.

Aprazer’s products, marked by their quality, are accepted worldwide.

It manufactures a range of GIT drugs-

• Proton pump inhibitors
• Gastroselective antibiotics
• Hepatoprotective drugs

Proton-pump inhibitors relieve gastric issues. How? 

It depletes the acid pump in the stomach.

It inhibits acid secretion.

These are widely used to resolve gastric issues like heartburn and irritation.

When are the acidity medicines used?

These are widely used to relieve symptoms of excess acid.

It is usually prescribed for the short term (2-8 weeks).

It brings symptomatic relief in-

• GERD– It is used to relive heart burn.

• Peptic ulcer disease – Aid to heal gastric /duodenal ulcers by suppressing acid secretion.

• Prophylaxis treatment – It is used to prevent GIT bleeding while using NSAIDs and aspirin.

• Esophagitis: Inflammation in the esophagus.

The risks involved in long-term use of acidity medicines (PPIs) 

Regularly using proton–pump inhibitors for more than one year increases the risk of –

• Bone fracture- 

It reduces the absorption of calcium, weakening bones.

• Reduces Nutritional absorption

It depletes the acid needed for absorption.

It leads to deficiencies like –

• low vitamin B-12
• low magnesium
• low iron

• Increases the risk of infection- 

It lowers the protective acid amounts in the stomach.

It increases vulnerability to infections-

• SIBO
• Clostridioides difficile
• Upper GIT tract infection

1. 1. Kidney impairment – It increases the risk of CKD or acute kidney injury.

• Gastric Polyps and Cancer Risks- It can cause hypertrophy of cells in the stomach.

• Rebound hyperacid secretion – Abruptly stopping the medicine can lead to rebound acid secretion.

Conclusion- 

One should use PPIs for a short duration for quick relief.

These do not offer a cure to any chronic GIT disorder.

These must be used in low doses.

For long-term use, one must consult a doctor.

In an era of quick fixes and marketing hype.

The exaggerated glutathione drips claim miraculous skin whitening and rapid anti-aging.

Marketing emphasizes a complete, permanent change in skin tone, but the reality is far more than a gimmick.

The repeated use of high doses of glutathione IV drips in spas and cosmetic centers may lead to-

• Toxicity
• Severe shock
• Organ failure
• Allergic reaction
• Air embolism

As a pharmaceutical manufacturer, Aprazer Healthcare manufactures a comprehensive range of oncology drugs and supportive therapies.

Committed to safety and the highest quality, we manufacture global standard products.

We aim to bridge the gap between the market hype and reality, manufacturing precise-dose Glutathione Injections – Glutakast.

A safe alternative to unregulated, unverified formulations.

What is a Glutathione injection?

An antioxidant produced in the body.

• Neutralizes free radicals
• Repairs damaged tissues
• Enhance immunity

What are Glutathione IV drips?

These are formulations for intravenous glutathione administration.

It consists of 3 amino acids –

• Glutamate
• Glycine
• Cysteine

The antioxidant is directly delivered into the bloodstream.

It bypasses the digestive system.

It shows 100 percent bioavailability.

Glutathione injection uses- 

• Reducing chemotherapy neurotoxicity
• Treating paracetamol overdose
• Alcoholic fatty liver
• Peripheral artery disease
• liver detoxification
• Skin whitening
• Autoimmune support
• Skin brightening
• Anti-aging

How is Glutathione used for skin treatments?

It reduces the secretion of melanin.

It lightens the skin tone.

Glutathione can be given-

• Orally- it is used for antioxidant properties, immune health, and skin toning.
• Topically – It is used for local skin lightening (hyperpigmentation)
• Intravenously –Widely used for skin lightening /liver detoxification

When are Glutathione IV drips unsafe?

It is widely used in an unsafe manner in the cosmetic industry.

The IV infusions are administered by untrained professionals, without evaluating underlying health conditions.

These are generally procured from unregulated licensed providers.

The glutathione drips for cosmetic use contain a 5 times higher dose of safe bacterial endotoxins.

It carries severe health risks –

• • Severe skin reaction

• Organ dysfunction

• Endotoxin poisoning

What are the long –term side effects of Glutathione IV drips?

Long-term repeated high dose can lead to –

• It stresses the organs
• It can lead to liver /kidney failure
• It increases skin sensitivity
• Increases risk of skin cancer
• Thyroid dysfunction
• Nutrient depletion
• Mineral deficiencies

Who should not use Glutathione?

• Pregnant/ Breastfeeding women
• Asthma /lung disorders
• Liver /kidney diseases
• People taking weight loss medication
• Severe allergies
• People with mental health issues

Conclusion – 

It is recommended to use glutathione only under medical supervision.

It is a prescription drug.