Aprazer Healthcare, a hepatology medicine manufacturer from India, is a leading pharmaceutical exporter. 

Our flagship products Tafnext (Tenofovir Alafenamide) and Tudobest (Tenofovir Disoproxil Fumarate) form the backbone of Hepatitis B /HIV treatment, offering an affordable treatment regimen across the globe.

Tafnext (tenofovir alafenamide), as the newer-generation drug, is highly preferred in patients with kidney dysfunction or osteoporosis.

Tudobest (tenofovir disoproxil fumarate) offers a safer profile to be used in pregnancy and cardiovascular patients.

With worldwide availability and global quality, Aprazer Healthcare is the highly prescribed brand for hepatology treatments.

Our product portfolio comprises a diverse range of antiretroviral combinations.

• Hepatitis B medicines
• Hepatitis C medicines
• HIV medicines

What is the difference between TAF/TDF?

TAF is Tenofovir Alafenamide.

TDF is Tenofovir disoproxil fumarate.

The difference lies in terms of absorption /bioavailability, which determines the dose.

Why is TAF considered superior to TDF?

TAF is a newer-generation targeted therapy drug.

It requires less dosing, thus offers fewer side effects.

When is TAF used?

It is given to people who have underlying health conditions –

• Osteoporosis
• Kidney dysfunction
• Elderly patients

When is TDF prescribed?

It is given in conditions with –

• • Cardiovascular issues

• Highly preferred in pregnancy

• It can be used on demand, 2-24 hours for pre-exposure prophylaxis.

Can I shift my drug from TDF to TAF?

It can be shifted after consulting the doctor.

It depends upon the medical history.

The parameters to be considered include-

• bone health
• kidney functions
• lipid functions
• cardiovascular health

Can TAF/TDF be used in HIV infections?

• HIV Prevention (PrEP)-

These can be used alone in HIV–negative individuals for pre-exposure prophylaxis.

TDF can be used on demand.

TAF requires daily dosing.

• HIV treatment – 

Neither of the two drugs is used alone for HIV treatment.

They must be combined with other antiretrovirals.

Using it alone may lead to the development of drug resistance.

Does TAF/TDF prevent viral spread?

The antiviral drugs suppress the viral count to uncountable (negligible) levels.

It prevents the transfer of from mother to child.

It also prevents sexual transmission.

Having an active viral count does not offer any prevention.

Conclusion – 

TAF/TDF are the first-line antivirals for Hepatitis B.

Neither of the antiviral drugs can be stopped abruptly.

It can lead to viral reactivation or resistance.

During HIV co-infections none is used as standalone.

Women account for 60 percent of osteoarthritis cases globally.

Postmenopausal women exhibit the highest disease burden.

Knee joints are affected first, followed by the hip joint and hands.

The earlier symptoms are mild and infrequent, so easily ignored.

Recognizing early signs and timely intervention prevents disease advancement.

Identifying the systemic or immune-based inflammation helps mitigate disease progression.

Irreversible damage can be prevented by early medications.

As the leading rheumatology drug manufacturer, Aprazer Healthcare manufactures a comprehensive range of rheumatology medicines.

We are the rheumatology drug exporters to international markets.

Following WHO standards and quality parameters, we manufacture drugs for global supplies.

Our flagship rheumatology medicines include-

• Hydroxychloroquine Sulphate-  Hqkast 200
• Tofactinib- Tofamark

What are the reasons for developing arthritis in women?

Hormonal factors – 

Estrogen secretion stops after menopause.

Estrogen protects joints and controls inflammation.

A rapid fall in estrogen levels loosens the ligaments in the knee.

Physical structure- 

Women have wider hips compared to men.

The unequal pressure on the hips and knees increases the risk of hip damage.

Immune system differences 

Women are at risk of autoimmune diseases.

The immune system is more reactive compared to men.

Females are 2-3 times more affected by immune system attacks.

Obesity 

The increased weight leads to intense physical pressure on the knees/hip.

It causes systemic inflammation.

It damages the cartilage.

It also erodes the bones.

Pregnancy/childbirth 

Pregnancy causes changes in posture/ gait.

Childbirth causes a release of relaxin hormone.

It widens the pelvis.

It affects the cartilage and the joints.

It also causes metabolic changes, causing joint inflammation.

Emotional psychological factors

Chronic stress releases stress hormones.

These alter the immune response.

Sleep disturbances impair tissue repair.

Genetics – People with a family history of arthritis are prone to developing joint inflammation/arthritis.

The symptoms of arthritis- 

• Joint pain
• Swelling and stiffness
• Fluid accumulation in the joints
• Reduced motility

The early arthritis signs to be watched – 

• Stiffening of the joints while sitting /resting.
• Losing grip in the hands.
• Locking of the joints.
• Joints unable to bear full pressure
• Morning tenderness across the ankles and feet
• Persistent pain across the groin area
• Friction in moving joints

The arthritis treatment is focused on –

• Reducing joint pain
• Managing stiffness /swelling
• Preventing disease progression

The commonly used medicines include- 

Pain killers/ anti-inflammatory drugs.

• Analgesics help relieve mild –moderate pain.
• NSAIDs reduce inflammation and pain.

Disease-modifying anti-rheumatic drugs 

These are the drugs that prevent progressive damage of the joints.

These drugs target the immune pathways and inhibit the immune attack on the joints.

Corticosteroids 

These are the anti-inflammatory drugs.

They prevent sudden immune flare-ups.

It suppresses severe inflammation.

 Viscosupplementation- 

The hyaluronic acid injections are given in the joints.

It mimics the joint fluid properties.

It prevents joint damage.

How to prevent arthritis progression? 

• Active lifestyle
• Managing weight
• Proper diet.
• Quitting smoke
• Timely medication /treatment

Diabetes does not remain confined to increased blood sugar.

Over the years, diabetes damages your kidneys silently.

Diabetes continues to be a leading cause of kidney failure. 

Controlled sugar levels reduce disease progression.

However, it does not eliminate the risk.

Let’s understand the link between diabetes and kidney damage. 

Early identification can be a preventive approach.

It can stop the progression of the disease to an end-stage kidney disorder.

Focused on kidney disease treatments and prevention, Aprazer Healthcare manufactures a range of affordable nephrology medicines.

We are the leading nephrology drug manufacturer, exporting kidney medicines worldwide.

Our product portfolio consists of –

• Anti- diabetic combinations 

• Kidney transplant medicines 

• Nephrology and diuretics 

How does diabetes damage kidneys?

High blood sugar is often accompanied by high blood pressure.

The kidney damage occurs through several mechanisms –

Hyperfiltration and mechanical stress- 

Chronic high sugars strain the tiny blood vessels.

It increases kidneys to work harder.

The kidneys stop filtering proteins.

The proteins leak into the urine.

Damaged blood vessels- 

The increased glucose stiffens the blood vessels.

It thickens the blood and induces clogging.

Nerve damage- 

It damages the nerves of the bladder.

It leads to buildup of back pressure on the kidneys.

It also increases the risk of UTI.

Scarring – The injury to the nephrons slowly leads to scarring.

It destroys the ability to filter blood.

What are early signs of kidney damage, a diabetic must never ignore? 

• Foamy urine – 

It indicates that the filtering capacity of the kidneys is damaged.

The kidney is not able to retain proteins.

The proteins are directly excreted into the urine.

• Edema – 

It is the swelling in the feet, hands, and ankles. Puffy eyes.

It is caused when the kidney is not able to excrete the excess fluid or sodium.

It leads to water retention.

The excess fluid leaks from the blood capillaries.

• Increased urination at night 

In conditions of high sugar, the body excretes excess sugar through the urine.

It increases urination. It leads to water depletion.

It increases strain on the kidney cells.

It can damage nephrons.

• Persistent high blood pressure- 

Kidneys regulate blood pressure.

It filters out excess salts and water.

Any damage to the kidneys decreases their capacity to filter.

It increases blood pressure.

• Unusual weight gain 

A person gains excess weight due to fluid retention.

It is not the muscle weight; it’s the weight of the water retained in the body.

Long-term warning signs – 

• Weakness /fatigue – 

Kidneys produce a hormone that forms blood.

The damage to the kidney leads to reduced formation of blood.

It leads to –

• Anemia
• Chronic weakness
• Changes in taste, nausea – 

The unfiltered blood leads to toxin buildup in the blood.

It causes metallic taste or vomiting.

• Edema in the lungs 

Fluid builds up in the lungs.

It causes difficulty in breathing.

It leads to shortness of breath.

• Muscle cramps /pain- 

Altered kidney filtration leads to electrolyte imbalance.

It leads to increased potassium and magnesium, and low calcium.

Acid- base imbalance.

• Increased Insulin Levels- 

Kidneys break down insulin.

The damaged kidneys are not able to metabolize insulin.

It causes an increased level of insulin.

Conclusion – 

Know your kidneys; kidney disease is silent.

The damage reaches the advanced stages before the usual symptoms appear.

The early sign is often albuminuria, which starts many years before symptoms.

For a diabetic, it becomes more important to have regular monitoring of the kidneys.

Aprazer Healthcare is a pharmaceutical manufacturer.

With the largest oral solid plant at Haridwar, we are capable of manufacturing different solid dosage forms.

We are equipped with end-to-end continuous manufacturing systems, processing the powdered forms to final coated tablets.

The Triad of Dosage formulation 

A dosage form is as important as the drug itself.

A successful formulation delivers the drug safely and effectively to the site.

It includes an intricate process of-

• Consistent release
• Enhanced absorption
• Drug stability

Different types of Oral dosage forms- 

• Tablets
• Capsules
• Powders and granules

The components of solid dosage formulations- 

API – The active pharmaceutical ingredients.

It gives the therapeutic effect.

Excipients – These are the components used to blend with API.

It enhances its –

• Solubility
• taste
• stability
• shelf life
• compressibility

Finished product – the capsule or tablets that are consumable

Packaging – The tablets or the capsules are dispensed into sealable outer coverings to prevent degradation.

The critical steps involved in manufacturing solid oral dosage forms

Preformulation studies – 

It is the investigational phase.

The physical, chemical, and biochemical properties of the API are studied.

It provides necessary data that helps excipient selection.

Compatibility testing – 

It is the analysis of the interactions between the drug and the excipient.

The API mixture and the selected excipient are subjected to stress testing.

It is passed through analytical testing.

• HPLC
• Differential Scanning Calorimetry (DSC)

Prototype creation- 

A small batch is prepared at laboratory scales.

It is tested for physical prototypes.

• Hardness
• Friability
• Dissolution

Stability and shelf life testing 

It includes accelerated testing.

It is done to predict-

• Shelf life
• Long-term degradation
• Expiry date

Scaling up production 

In this the operational parameters are adjusted.

• Compression force
• Mixing speed
• Drying times

It ensures batch-to –batch consistency and uniform API distribution.

Regulatory dossier preparation

It is the compilation of all the documents for regulatory approvals.

The operational stages include – 

• Weighing /dispensing
• Milling/blending
• Granulation
• Drying /screening
• Compression/encapsulation
• Coating

Aparzer’s expertise in manufacturing oral dosage forms

Meeting the diverse needs of customers, we manufacture small batches to large volume productions.

Equipped with extensive granulation techniques, we are capable of manufacturing compressed tablets to complex dosage forms.

The types of oral dosage forms manufactured at Aparzer Healthcare includes-

• Uncoated tablets
• Film-coated tablets
• Modified release tablets
• Oral dissolving tablets
• Capsules

High blood pressure often remains silent and unnoticed.

However, the rise during pregnancy can severely affect both the child and the mother.

Quick facts –

• Preeclampsia affects 3 to 8 % of pregnancies across the world.
• It accounts for 16% of global maternity deaths.
• It contributes to preterm deliveries in 45% of pregnancy cases.

As the drug manufacturer, Aprazer Healthcare manufactures a range of antihypertensive combinations offering effective, safe BP control.

We are the leading antihypertensive drug exporters from India.

Labetalol (labzer) manufactured by Aprazer Healthcare is globally prescribed for hypertensive control in pregnancy.

Why does blood pressure rise in pregnancy?

Blood pressure rises during pregnancy due to underlying health conditions –

• Obesity
• Smoking
• Having a first pregnancy
• Pregnancy after 40 years of age or before 18 years of age.
• Diabetes
• Chronic diseases
• Pregnancy with twins and triplets

Know the types of hypertension in pregnancy- 

The blood pressure rises after the 20th week of pregnancy.

The high BP ranges above 140mmg hg/90mm hg.

• Gestational hypertension – 

It is the rise in blood pressure without severe complications.

It does not show any symptoms.

It resolves within 12 weeks after childbirth.

• Preeclampsia 

It is a severe rise in blood pressure during pregnancy.

The high BP directly damages the internal organs – Liver /kidney

It can occur before or after childbirth.

• Chronic hypertension 

It is a condition in which the mother already suffers from high BP.

It is caused by underlying diseases.

What are the risks posed by high BP during pregnancy?

• Reduced blood flow to the placenta –

The high BP reduces the flow of blood to the placenta.

It reduces the flow of oxygen and nutrients to the fetus.

• Placental abruption 

The high BP can detach the placenta from the inner wall of the uterus.

It can lead to severe bleeding.

It can be fatal to both the baby and the mother.

• Decreases fetal growth

Improper supply of nutrients restricts the weight and the development of the fetus.

•  Injury to internal organs

High BP may injure the internal organs.

• Premature delivery 

It increases the chances of undeveloped organs in the fetus and before time delivery.

• Risk of cardiovascular diseases 

High BP can increase the risk of getting cardiac complications in the future.

What are the symptoms of high BP while pregnant?

Hypertension is followed by symptoms –

• Persistent high BP
• Severe headache
• Protein in urine
• Vision changes
• Pain in upper abdomen
• Nausea /vomiting
• Fluid retention

Which is the commonly used medicine to control high BP in pregnancy?

Oral Labetalol (Labzer) therapy is used to maintain a steady level.

Labetalol is chosen because –

• Safer profile for both the mother and the child.
• Faster onset of action.
• Fewer side effects
• Dual mechanism of action

It is widely used in blood pressure hovering over a range of –

140/90mm hg and 159/109 mm Hg

It is used as first-line treatment to manage gestational hypertension.

Aprazer Healthcare – The Top Pharmaceutical Drug Manufacturer

Manufacturing over 200 + generic drugs, we are the leading drug exporters and suppliers from India.

We specialize in manufacturing cardiovascular medicines.

Our product portfolio consists of global standard medicines.

• Anti-hypertensive combination
• Lipid–lowering agents
• Anti-lipemic agents

Know the difference- 

They are both erectile dysfunction medicines, often used interchangeably.

Both of them have similar functions and a similar mode of action.

The difference lies in the duration of action.

Tadalafil is widely used for spontaneous sexual activity for a longer time.

Its effect lasts for more than one and a half days.

Sildenafil is used for sexual activity for a short duration.

Its effects last for 4 hours.

When does the doctor prescribe tadalafil /sildenafil?

It is prescribed based on patient history and lifestyle choices.

It depends on the sex frequency.

Those requiring regular sexual activity prefer tadalafil.

On a daily dose basis, doctors prescribe a low dose of tadalafil.

It builds up in the penile tissue and causes spontaneous erections upon arousal.

It is used to maintain constant levels in the body, rather than taking a tablet every day before sex.

Tadalafil can be used to treat BPH along with erection.

Sildenafil is used for a shorter-duration effect.

It has a shorter half-life.

It is eliminated faster from the body.

Those with infrequent sex use sildenafil.

Can I take both together for a stronger erection?

One should not use the 2 tablets together or even take double doses.

It can lead to prolonged painful erections.

An overdose can damage the penile tissue.

It can cause a severe drop in blood pressure.

It can lead to hypotension.

Other side effects include –

Lightheadedness, dizziness, fainting

Tadalafil /sildenafil are available in different strengths – 

Tadalafil is available as –

2.5/5/10/ 20mg.

Sildenafil is available as –

25/50/ 100 mg.

The perfect time to take tadalafil /sildenafil tablet- 

A single tablet is taken 30-60 minutes before performing sex.

For continuous effect, tadalafil is given in short doses of 2.5 or 5 mg daily.

Sildenafil must not be used after a heavy meal.

Tadalafil can be used with/without food.

Aprazer Healthcare- The leading erectile dysfunction medicine manufacturer

As the ED drug manufacturer, we are focused on developing effective medicines to improve men’s sexual health.

We manufacture the widest range of global quality ED medicines.

Recognized as the top drug exporters, we export world-class erectile dysfunction combinations globally.

The widely used ED medicines-

• Viabest-100, Tadabest – Erectile dysfunction medicine
• Super-viabest – Premature ejaculation medicine

Smoking not only increases the risk of pulmonary diseases.

It directly affects muscle strength.

Tobacco use is increasing in epidemic proportions across the world.

82% of adult smokers begin smoking before 25 years of age.

1/5 of the youth start regular smoking by the age of 15.

Delving deep, let’s understand how smoking/nicotine affects muscle strength.

Smoking increases muscle breakdown.

It reduces oxygen delivery to muscles.

The toxic components in tobacco stop muscle formation.

Inhibits protein synthesis –

It stops the synthesis of muscle proteins.

It increases the breakdown of the muscle.

It imbalances muscle formation and muscle degradation.

Impair nutrient synthesis

The rapid muscle breakdown leads to nutrient depletion.

It suppresses the body’s ability to repair muscles.

It reduces muscle strength.

Diminished oxygen supply 

Smoke produces carbon monoxide.

It binds with hemoglobin.

It reduces the binding of oxygen.

The oxygen supply to the muscles/organs is diminished.

Vascular damage 

Smoking causes vasoconstriction.

It stops the formation of new blood vessels.

It increases the risk of clot formation.

Thus interrupting the blood flow.

Hormonal imbalance 

The nicotine present in smoke alters the endocrine hormones.

It increases cortisol levels, increasing muscle breakdown.

Suppressing testosterone reduces muscle build-up.

Systemic Inflammation- 

Long-term smoking infiltrates the blood with cytokines.

It causes a constant state of low-grade systemic inflammation.

It drives muscle wasting.

Does nicotine improves athletics performance?

Nicotine is believed to boost short-term improvement.

However, the long-term side effects outweigh the short-term benefits.

• Nicotine increases the heart rate.
• Improves blood flow.
• It increases motor function.

The chronic use of nicotine has a severe downside.

It leads to dependency.

Athletes are unable to perform without nicotine.

It hijacks the endocrine and sympathetic nervous system.

It leads to a chronic semi-alert state.

It imbalances the transition from performance to recovery.

It impairs-

• sleep quality
• Inhibits muscle repair and formation
• Cognitive function
• Decreases strength and power

Just 14 days of quitting smoking significantly improves muscle endurance.

Over a year of smoking cessation, the body gains up to 17- 23% of muscle strength.

Tips to help muscle growth and strength- 

• Resistance exercises
• Protein-rich diet
• Healthcare supplements

The widely used amino acid supplement used by athletes to improve muscle strength-

Hepakast – L-leucine, L-isoleucine, L-valine (BCAA) sachets, manufactured by Aprazer Healthcare.

These are the branched chain amino-acids essential for muscle building.

• It enhances muscle repair and recovery.
• It reduces muscle breakdown.
• It supports muscle maintenance, providing additional energy.
• It reduces exhaustion during workouts.

Aprazer Healthcare is a pharmaceutical manufacturer. 

We manufacture a wide range of life–saving medicines and healthcare products.

Beyond its specialty in manufacturing oncology medicines, Aprazer Healthcare continues to expand its portfolio, manufacturing a comprehensive range of generics.

Having global footprint, Aprazer Healthcare is a recognized pharmaceutical company, manufacturing global-quality products.

Open to partnerships, Aprazer Healthcare is a global pharmaceutical choice.