It is the middle age, when plaque starts to deposit in the arteries.

Cholesterol levels must be controlled from the 30s.

High cholesterol levels are a silent killer.

It remains asymptomatic for years.

It shows up in the form of a heart attack or stroke, years later.

Proactive Cardiac Care – Early Statin Therapy 

Cholesterol levels (LDL) are directly linked to cardiac health.

The cardiovascular risk is determined based on –

• cholesterol levels
• metabolic dysfunction
• family history
• genetics
• smoking
• Weight, etc.

10-year or elevated 30-year risk factors are evaluated.

The risk factors are classified as low, medium, or high.

The updated guidelines for LDL levels to be targeted-

• Below 100mg/dl –for people at borderline risk
• Below 70mg/dl – for intermediate risk
• Below 55mg /dl – for low-risk people

Prescribing statins in your 30s significantly lowers the risk of cardiovascular issues.

Statins are the first-line therapy due to several benefits –

• Lower cholesterol (LDL) synthesis in the liver.
• Reduce inflammation
• Stabilize existing plaque in the artery walls
• Excellent safety profile

The low LDL levels prevent-

• The accumulation of plaque in the arteries.
• It prevents atherosclerosis.
• It reduces the long-term risk of blockage
• Reduces risk of heart attacks and strokes.

Affordable range of Statins 

Aprazer Healthcare is the leading drug manufacturer.

We manufacture a range of generic statins.

• Atorvastatin
• Rosuvastatin
• Simvastatin

Types of anti-cholesterol medicines 

• Statins – They inhibit the reductase enzyme in the liver.

It reduces cholesterol formation.

It is a widely prescribed drug.

It is highly safe and effective.

• Cholesterol absorption inhibitors – 

Reduce the cholesterol in the small intestine.

It reduces its absorption.

• Injectable medications- 

It is injected in conditions of very high cholesterol levels.

It clears the cholesterol from the body.

• Bile acid sequestrants – 

It binds to the bile that is excreted.

It increases the utilization of blood cholesterol.

• ACL inhibitors – It lowers LDL formation in the liver.

It is used by people who cannot use statins.

• • Fibrates – These lower triglycerides. They increase good cholesterol levels.

• Niacin – A vitamin regulating lipids.

Why get cholesterol levels tested?

Increased cholesterol levels remain asymptomatic.

Annual testing is required for people of all age groups (above 30 years).

Frequent testing is required for –

• Family history of cardiovascular disease
• Existing health conditions
• obesity/smoking

Aprazer Healthcare – Manufacturing Lipid-Lowering Drugs 

Aprazer Healthcare, as the drug manufacturer, manufactures a range of cardiovascular drugs.

Our product portfolio consists of –

• Anti-hypertensive drugs
• Lipid-lowering drugs
• Blood thinners

does-cholesterol-need-a-check-in-your-30sAdhering to the highest manufacturing standards, we are a global drug manufacturer.

We export lifesaving medicines and affordable generics to countries worldwide.

We are the drug exporters to Africa and Asia.

Changing lifestyle and the rise in diseases has fled the demand for generic medicines.

The emerging economies rely on generic drugs for affordability and availability.

The generic drugs offer cost-effective alternatives with the same clinical outcomes.

The healthcare system is shifting towards precision and targeted therapies.

Pharmaceutical manufacturing is transitioning to develop advanced therapy medicines and complex generics.

Complex generics are generic drugs, manufactured with the latest advancements in novel drug delivery systems, offering a targeted approach.

Aprazer Healthcare – The Generic Drug Manufacturer 

Aprazer Healthcare is at the forefront of manufacturing advanced drugs.

• Complex generics
• Branded generics

Leveraging cutting-edge technology, we manufacture the new treatment drugs.

We specialize in manufacturing –

• Modified release tablets/capsules.
• Pre-filled syringes
• RTU technology injections

We are generic drug manufacturers; we are global exporters of a large range of pharmaceutical products.

What are generic drugs?

Generic drugs are medicines that are brand equivalent.

They have the same therapeutic efficacy, safety, and strength as the branded drugs.

Branded drugs are patent medicines manufactured or invented by the company that owns the patent.

These are developed by extensive research and the drug development process.

The manufacturing company retains the rights to manufacture the drug.

They are higher in cost.

What are complex generics?

These are the brand equivalent drugs that contain complex APIs, formulations, and dosage forms.

The various forms include-

• • Complex dosage forms – Transdermal patches
  • Drug – device combination – Inhalers, Auto-injectors

• Complex API – Peptides, liposomes 

• Modified release mechanisms- controlled release formulations

• Locally acting drugs – creams, ophthalmic preparations, etc.

Challenges in manufacturing complex generics 

The manufacturing of advanced therapy drugs involves both technological and regulatory advancements.

The hurdles faced in manufacturing complex therapeutics include-

Technical complexity – 

Manufacturing complex products requires complex equipment and advanced technology.

It requires multi-step controls and testing compared to standard medicines.

Clinical studies required – The development of a complex system requires human trials compared to a conventional drug system.

Patent hurdles – Manufacturing device combination may include a patent or copyright for the use of a device component or parts.

Undeveloped regulatory standards – The regulatory systems are not developed to approve advanced drugs. It leads to delays and failures.

Scale up and process consistency – scaling up complex manufacturing processes and maintaining consistency add up to the rigor.

The development of complex therapeutics requires high investment costs.

Aprazer Healthcare is the leading manufacturer of complex generics.

With world-class infrastructure, Aprazer Healthcare aligns with the latest technological advancements.

These are the two documents that are important to import a pharmaceutical product into the destination country.

It ensures that the product to be imported is safe and efficient to be sold in the desired market.

It gives marketing access to the importers for the product.

The two files contain standard steps to harmonize the quality and safety of the products, opening gateways to countries worldwide.

What is CTD (Common Technical Document)?

It is a set of documents that is submitted to the regulatory authorities.

It consists of applications for the authorization to market the pharmaceutical product.

It is developed by the International Council of Harmonization that a single dossier shall be submitted to different regulatory bodies.

It consists of 5 modules.

Module 1 is specific to the country.

The other module remains the same for all the regions.

• Module 1 – It specifies the local labeling or the prescribing content as per the country.
• Module 2 – It summarizes the quality of the finished product.
• Module 3- It consists of the complete details of chemicals used, quality controls, and manufacturing processes.
• Module 4 – It contains all the non- clinical study reports.
• Module 5 – It includes the clinical study reports.

What is DMF (Drug Master File)?

It is a confidential document.

It is submitted by the manufacturer.

It consists of the manufacturing details of the API, intermediates, and the packaging material.

It consists of –

• Details about the API, its synthesis, and processes.
• Manufacturing facility layout, manufacturing processes used.
• Quality protocols, stability, shelf life, etc.

Why is it required for importers?

Importers need these 2 documents to ensure legal compliance-

• It is required to approve a new product in the market.
• It is proof of quality.
• It ensures the ingredients used are pure, safe, and stable.
• It protects intellectual property rights.
• It streamlines the global entry.
• Verify batch consistency and purity.
•  build trust based on assured quality

Aprazer Healthcare Steadfast Import Approvals

Aprazer Healthcare navigates the regulatory processes without undue delays.

• Submitting dossiers
• Obtaining authorizations.

We maintain stringent quality parameters and standardized manufacturing processes.

By submitting true and unbiased information, we work in the interests of the stakeholders.

Our foundation, built on consistency and reliability, makes us the leading healthcare partners.

We are a leading pharmaceutical exporter to Asia, Africa, and South America.

Munching on a chocolate bar or grabbing a pair of chips, the youngsters are unaware of getting trapped in a chronic syndrome.

Fatty liver is silently hitting the youth. It is no longer a disease confined to old age.

It is rapidly rising, affecting the majority of young girls and boys at the age of school or college.

The conundrum is that the condition remains silent.

The condition gradually reaches the advanced stages.

Know the fatty liver disorder – 

It is a chronic liver condition.

It starts from the accumulation of fat in the liver.

It can cause tissue scarring and advanced liver disorder.

The high amount of fat can cause inflammation.

It causes tissue injury.

What are the fatty liver types? 

Alcoholic Fatty Liver – 

Fatty liver is usually caused by alcohol.

Alcohol reduces fat metabolism.

It causes fat deposits in the liver.

Non Alcoholic Fatty Liver – 

The accumulation of fat in the liver is due to metabolic dysfunction.

The liver function gets impaired due to –

• Obesity
• Diabetes
• High lipids

Why is fatty liver disease happening more in the young? 

Lifestyle is the leading factor.

The prolonged hours of desk jobs combined with processed food.

Use of excessive salts and sugars.

Poor sleep habits combine to cause-

•  Metabolic dysfunction.
• Distorts glucose metabolism
• Disrupts fat breakdown

Fatty liver causes other than alcohol- 

Obesity/excess weight –  

The excess fat settles in the liver tissues.

It can lead to inflammation.

It often causes insulin resistance.

Poor diet – 

The high intake of processed food.

The extra calories get accumulated as fat.

The body is unable to metabolize glucose. It deposits in the form of fat.

Metabolic disorders – 

These interfere with insulin sensitivity.

Inhibits fat breakdown.

It causes excess fat production and its accumulation in the liver.

Physical inactivity- 

Due to reduced physical activity, the fat is not metabolized or burned.

The fat gets stored in the liver.

It leads to liver dysfunction.

Rapid weight loss diets- 

It overloads the liver to burn excessive fats.

It causes inflammation.

Fat breakdown causes fatty acid influx.

It can cause nutritional deficiency.

It causes the liver to work hard.

What are symptoms of fatty liver? 

At an early stage the fatty liver does not show symptoms.

It progresses to form advanced disease.

• Fatigue and weakness
• Abdominal pain
• Fluid retention
• Loss of appetite
• Unusual weight loss

The treatment and medicines used in fatty liver –

The fatty liver can be reversed by changing lifestyle and habits.

Improving diet and exercise can cause a reversal.

The advanced stages include the use of liver supportive medicines like –

Udikast 300 – Ursodeoxycholic acid tablets

Ocabest 10 – Obeticholic acid tablets

Aprazer Healthcare – Pioneering Liver Medicines 

Aprazer Healthcare is the leading pharmaceutical manufacturing company.

We are focused on manufacturing drugs targeting liver diseases and the underlying causes.

We have top-class R&D infrastructure.

Aprazer Healthcare is a major player in manufacturing advanced liver care medicines.

We specialize in manufacturing oncology treatment drugs for liver cancer.

We are the largest hepatology medicine manufacturer.

We manufacture drugs for chronic liver diseases like –

• Hepatitis B
• Hepatitis C
• Primary biliary cholangitis
• Fatty liver

Aprazer Healthcare stands at the forefront of manufacturing affordable hepatitis B medicines that are widely used for prophylactic treatment to reduce the risk of transmission in pregnancy.

We wish every child born is safe and healthy. Reaching the global platform, we ensure affordable treatment reaches the needed.

The hepatitis B virus in the mother is unsafe for the newborn.

It can be easily transmitted.

Having hepatitis B previously increases the risk manifold.

The virus remains dormant for years.

It may not show in the blood, but the liver cells significantly have the virus.

Even people who have no viral symptoms are at risk of transmission.

Unknowingly, it gets transferred to the newborn.

Timely diagnosis and prevention become crucial.

Can we prevent Hepatitis B transmission from mother to child? 

Screening – The mother needs to get screened for viral loads before planning a pregnancy.

The women with high viral loads must start antiviral treatment.

Antiviral treatment – The antiviral medicine consists of regular use of tenofovir.

It starts from the 3rd trimester.

It extends several months after delivery.

The prophylactic antiviral drug widely used during Hepatitis B pregnancy –

Tenofovir Alafenamide tablets – Tafsure, Tafnext 

It is the newer generation drug to reduce (hepatitis B) viral load in pregnancy.

It has targeted action. It reduces the viral count in the liver.

It has a better safety profile.

It has less renal toxicity.

It has low bone loss side effects.

Post birth treatment- Immediately after birth, the child is given immunoglobulin shots.

The first vaccine must be given within 12 hours.

The neonate should be given 2 or more vaccines within a time frame.

The course should be completed.

The child should be monitored after every vaccine dose.

The regular monitoring should be done annually.

Can a hepatitis B mother breastfeed the baby?

It is generally safe to breastfeed the child.

The virus is transmitted through – blood, body fluid, or semen.

It does not pass in milk.

Nipples should not be cracked.

They must not have open sores or bleed.

Conclusion – 

Hepatitis B transmission from mother to child can be highly prevented.

Early screening becomes mandatory.

It helps identify and rectify the hepatitis B transmission.

Proper vaccination and prophylactic treatment can significantly reduce the risk of transmission to zero.

Aprazer Healthcare – Innovating Hepatitis B Treatment 

Aprazer Healthcare manufactures the widest range of Hepatitis B medicines.

We are an Indian hepatology medicine manufacturer, supplying hepatology medicines to the international markets.

We are the trusted hepatitis B medicine manufacturer.

We are relied upon and authenticated for manufacturing affordable, quality – efficient medicines.

Our product catalogue consists of –

Tafnext – Tenofovir Alafenamide 25mg Tablet

Entecor 0.5 – Entecavir tablet

Tudobest – Tenofovir disoproxil fumarate tablet

Immunity is the targeted point of attack by HIV.

The advanced anti-retroviral drugs successfully suppress the viral load.

Despite the controlled viral load through anti-retroviral therapy, the lack of sleep and chronic stress accelerate the HIV progression.

At Aprazer Healthcare (HIV medicine manufacturer), we believe HIV management extends beyond viral suppression.

Patient awareness becomes crucial for holistic wellness.

As the leading pharmaceutical manufacturer, we aim to break the financial constraints, manufacturing an affordable range of generic HIV drugs.

We are the leading drug exporter of HIV drugs from India.

How do sleep deprivation and stress affect immunity in HIV?

Sleep- stress cycle depletes the immune functions.

It double hits the immune system along with HIV.

It leads to neuroendocrine dysregulation.

It increases low-grade inflammation, increasing the burden on the immune system.

The prolonged stress and inflammation lead to cell death.

It reduces the immune cell count.

Manage stress, sleep, and immunity in HIV infection- 

Strict adherence to the anti-retroviral therapy is the foundation for HIV treatment.

The best results are achieved when it is combined with targeted

Lifestyle changes-

Managing sleep and stress directly boosts CD4 cell count.

• Limit screen time
• Set a fixed sleep/wake-up schedule
• Stress management exercises
• Physical activity
• Proper diet
• Avoid tobacco
• Limit caffeine near to bed

The trio increases the risk of a heart attack. How?

It overly activates the hypothalamic-pituitary axis.

It causes excessive secretion of inflammatory kinases.

These damage the arterial wall.

It increases the heart rate.

The persistent immune activation increases wear and tear of the blood vessels.

It increases the blood pressure.

It increases the risk of a heart attack caused by oxygen demand – supply imbalances.

The highly prescribed HIV medicines worldwide- 

• Abakast L –Abacavir and lamivudine
• Lamipure– Lamivudine
• Lopikast – Lopinavir /ritonavir
• Temirazer- Tenofovir Disoproxil Fumarate, Emtricitabine
• Tudobest L – Tenofovir Disoproxil Fumarate ,Lamivudine
• Tudobest LE- Tenofovir Disoproxil Fumurate, Efavirenz,Lamivudine Tablets
• Virarazer – Tenofovir Disoproxil Fumurate, Emtricitabine ,Efavirenz Tablets

Aprazer Healthcare – Leading the fight against HIV with affordable solutions

It is the fundamental quality testing.

It is used globally by the pharmaceutical manufacturers to ensure patient safety and quality.

It’s the global health standard. It is accepted worldwide.

What is WHO-GMP certification?

It is the World Health Organization – Good Manufacturing Practices

WHO –GMP certification of the pharmaceutical manufacturing company, ensures its reliability.

It assures that the drugs manufactured are of-

• Standard quality
• Safe to use
• Effective and accurate dose

It confirms that the manufacturing unit follows strict quality and safety protocols.

How is WHO-GMP different from normal quality testing?

WHO -GMP qualifies and tests the entire manufacturing process.

It ensures the quality from the raw material to the final product.

It is a good manufacturing practice to be followed by the drug manufacturers.

It assures patient safety, quality, and reliability.

The normal testing assures the final product quality.

WHO- GMP adherence ensures the product manufactured is safe.

It follows a stringent process of formation.

Even without testing it ensure safe and effective preparations.

How WHO- GMP ensure medicine quality and safety?

WHO guidelines indicate a proactive strategy to mitigate potential risk and errors.

Strict Hygiene Protocols- 

WHO –GMP lays strict guidelines to ensure sterile and safe products.

It lays out cleaning processes of the equipment and the manufacturing areas.

It implements the use of a controlled environment with particulate control. It prevents microbial contamination.

• Using air filters (HEPA)
• Positive air pressures
• Unidirectional air flow
• using sanitizable surfaces

Batch to Batch Consistency – 

WHO recommends a standard procedure for manufacturing different batches.

It ensures consistent quality and dose accuracy between the two batches.

Purity and stability of the medicines – 

It suggests raw material testing, stability studies to ensure shelf–life.

Traceability and Accountability- 

WHO recommends maintaining comprehensive documentation from the procurement of the raw material to the launch of the product in the market.

It includes –

• Manufacturing protocols
• Packaging protocols
• Equipment logs
• Calibration records
• Batch distribution records
• Transportation logs
• Storage records

Aprazer Healthcare’s Commitment to WHO–GMP Standards 

Aprazer Healthcare is the top pharmaceutical manufacturing company.

We are focused on manufacturing global quality products.

We have WHO-GMP certified manufacturing facilities.

With strict adherence to the quality standards, we are focused on manufacturing safe and effective medicines.

Using high-quality API and robust quality controls, Aprazer Healthcare is a global name in manufacturing top-quality pharmaceutical products.

Our group of trained professionals ensures precision and care at every step of the manufacturing process.

Cancer treatment does not promise complete remission.

It often comes with several doubts in the mind.

How to have a quality life after cancer treatment?

How long do the side effects remain?

Will this cancer recur?

Life after cancer is more than a physical treatment.

It significantly affects both mental and emotional well-being.

It is a second chance at a new life.

The physical challenges after cancer treatment – 

The post-treatment cancer recovery is a long-term journey.

It involves a complex healing process.

Some days feel like fatigue is gone, but it returns on other days.

The effects caused by cancer treatment include –

• Persistent fatigue
• Nerve pain and numbness
• Weight changes
• Scarring or loss of body parts
• Swelling in arms or legs
• skin changes
• pain and mobility issues

Management tips to boost physical recovery after cancer treatment- 

Pain and fatigue can be maintained through various restoration processes-

• physiotherapy
• yoga
• exercise
• Antioxidant rich diet
• Compression therapy. It reduces swelling.

Reconstructive surgeries for lost body parts.

Resistant exercises to maintain muscle mass.

The emotional challenges after cancer treatment – 

Adjusting to a new normal is never a linear process.

Loss of identity or body part often leads to social distress.

Loss of hair, changes in body weight can lead to low self –esteem.

Feeling disrupted from the social circle.

Fear of recurrence.

Chemo brain is one of the ignored effects.

• Memory loss
• Mental fog
• Reduced focus
• Difficulty in multitasking

The management for emotional health includes – 

• Counselling sessions
• practice mindfulness
• Complete one task at a time
• Meditation
• brain exercises
• using memory aids

Rebuilding health with a holistic wellness plan – 

It is important to focus on oneself.

Know your body. Complete heavy tasks at the peak energy times.

Maintaining a strong routine becomes essential, which includes –

• Everyday exercise
• Hydration
• Stress management
• Healthy diet
• Healthy relationship

Aprazer Healthcare – Innovating Targeted Therapy Medicines 

As an oncology medicine manufacturer, Aprazer Healthcare manufactures advanced anticancer drugs.

We manufacture a wide variety of targeted therapy medicines that offer fewer side effects.

Leveraging cutting-edge technology, we manufacture innovative anticancer formulations –

• Chemotherapy medicines
• Targeted therapy medicines
• Hormonal therapy medicines

A urinary tract infection can spread to the kidney. It can cause scarring of renal tissues.

It affects the children most. The delay in diagnosis leads to inflammation and damage.

It occurs in cases of recurrent infections/ severe forms of infection.

What Causes Urinary Tract Infections?

It is the E.coli bacteria. It leads to urinary system infections.

It enters through the urethral opening.

It causes – burning sensation, pain, and increased urination.

How Does UTI Reach the Kidney?

When the infection gets severe. The bacteria from the urethra. It travels upwards to the kidneys.

It causes inflammation in the renal cells. It is often delayed in treatment.

It can lead to renal damage.

The Risk Factors for UTI and Kidney Infections

Delayed treatment is the major reason that leads to renal damage.

1. Females have a short urethra. It can ease the bacterial travel to the kidneys.

In older women, UTIs are common. It is due to the hormonal decline and weakened pelvic floor.

Recurrent infection leads to the kidney.

2. An obstruction to the urinary flow increases the risk of infection.

The blockage can be caused by –

Kidney stone or enlarged prostate

3. Children are prone to UTI infections. It happens due to –

Constipation

Urinary obstruction

Vesicoureteral Reflux- back flow of the urine

4. Medical conditions –

Diseases like diabetes, HIV. It lowers immunity.

It elevates the risk of getting a severe infection.

5. Multiple infections-

When an infection occurs again and again, it causes an additive effect.

It leads to an injury in the kidney.

It can lead to scarring.

6. The long-term use of a catheter can also increase the risk.

It directly opens a passage for bacteria.

7. Unhygienic conditions –

Using public toilets.

Not clearly washing the pubic area.

Not changing intimate clothing.

Why is a Kidney Infection a Serious Condition?

Long-term infection can cause systemic infection. It can cause severe renal injury.

It can lead to tissue scarring.

• It causes high blood pressure.

• Leakage of protein into the urine

• Chronic kidney disorder

• Permanent damage

What Are the Signs That a UTI Has Spread to the Kidneys?

• Very high fever

• Shivering

• Pain in the groin area

• Pain in the back and sides

• Painful urination

• Cloudy urine

• Smelly urine

• Nausea

• Vomiting

The Medicines for UTI

It involves a course of antibiotics –

• Nitrofurantoin

• Fosfomycin

• Cephalexin

• Ciprofloxacin

The Painkillers-

• Ibuprofen

• Paracetamol

Increase water intake. It dissolves toxins. Helps excrete bacteria.

Why Choose Aprazer Healthcare for Kidney Medicines?

Aprazer Healthcare is the leading nephrology medicine manufacturer.

It is the leading pharmaceutical medicine manufacturer.

It manufactures a wide range of products treating infections-

• Antibiotic combinations

• NSAIDS combinations

• Antispasmodic combinations

With multiple manufacturing plants across India, Aprazer Healthcare is recognized as the largest drug manufacturer and exporter.

It manufactures WHO-GMP-compliant drugs.